Results 21 to 30 of about 477,305 (254)

Serotonin 5-HT2A receptor expression is chronically decreased in the anterior cerebral cortex of male rats following repetitive low-level blast exposure [PDF]

Frontiers in Neurology
IntroductionMany Veterans who experienced blast-related traumatic brain injuries (TBIs) in Iraq and Afghanistan currently suffer from chronic cognitive and mental health problems that include depression and post-traumatic stress disorder (PTSD).
Rita De Gasperi, Rita De Gasperi, Georgina Perez Garcia, Georgina Perez Garcia, Miguel A. Gama Sosa, Miguel A. Gama Sosa, Gissel M. Perez, Rania Abutarboush, Rania Abutarboush, Usmah Kawoos, Usmah Kawoos, Patrick R. Hof, Patrick R. Hof, Patrick R. Hof, Carolyn W. Zhu, Carolyn W. Zhu, Carolyn W. Zhu, Stephen T. Ahlers, Gregory A. Elder, Gregory A. Elder, Gregory A. Elder, Gregory A. Elder   +21 more
doaj   +2 more sources

Low-level blast exposure disrupts gliovascular and neurovascular connections and induces a chronic vascular pathology in rat brain [PDF]

Acta Neuropathologica Communications, 2019
Much concern exists over the role of blast-induced traumatic brain injury (TBI) in the chronic cognitive and mental health problems that develop in veterans and active duty military personnel.
Miguel A. Gama Sosa, Rita De Gasperi, Georgina S. Perez Garcia, Gissel M. Perez, Courtney Searcy, Danielle Vargas, Alicia Spencer, Pierce L. Janssen, Anna E. Tschiffely, Richard M. McCarron, Benjamin Ache, Rajaram Manoharan, William G. Janssen, Susan J. Tappan, Russell W. Hanson, Sam Gandy, Patrick R. Hof, Stephen T. Ahlers, Gregory A. Elder   +18 more
doaj   +2 more sources

Mechanisms and pathophysiology of the low-level blast brain injury in animal models

NeuroImage, 2011
The symptoms of primary blast-induced mTBI, posttraumatic stress disorder and depression overlap. Evidence of an organic basis for these entities has been scarce and controversial. We present a review of animal studies demonstrating that low-level blast causes pathophysiological and functional changes in the brain. We monitor a time period from minutes
Annette, Säljö, Maria, Mayorga, Hayde, Bolouri, Berndt, Svensson, Anders, Hamberger   +4 more
openaire   +4 more sources

Repeat low-level blast exposure increases transient receptor potential vanilloid 1 (TRPV1) and endothelin-1 (ET-1) expression in the trigeminal ganglion. [PDF]

PLoS ONE, 2017
Blast-associated sensory and cognitive trauma sustained by military service members is an area of extensively studied research. Recent studies in our laboratory have revealed that low-level blast exposure increased expression of transient receptor ...
Elaine D Por, Melody L Sandoval, Chiquita Thomas-Benson, Teresa A Burke, Allison Doyle Brackley, Nathaniel A Jeske, Jeffery M Cleland, Brian J Lund   +7 more
doaj   +2 more sources

Chronic post-traumatic stress disorder-related traits in a rat model of low-level blast exposure. [PDF]

Behav Brain Res, 2018
The postconcussion syndrome following mild traumatic brain injuries (mTBI) has been regarded as a mostly benign syndrome that typically resolves in the immediate months following injury. However, in some individuals, symptoms become chronic and persistent.
Perez-Garcia G, Gama Sosa MA, De Gasperi R, Lashof-Sullivan M, Maudlin-Jeronimo E, Stone JR, Haghighi F, Ahlers ST, Elder GA.   +8 more
europepmc   +5 more sources

Occupational Risk of Low-Level Blast Exposure and TBI-Related Medical Diagnoses: A Population-Based Epidemiological Investigation (2005-2015). [PDF]

Int J Environ Res Public Health, 2021
Belding JN, Englert R, Bonkowski J, Thomsen CJ.   +3 more
europepmc   +2 more sources

Modeling Highly Repetitive Low-level Blast Exposure in Mice. [PDF]

J Vis Exp
Exposure to explosive blasts is a significant risk factor for brain trauma among exposed persons. Although the effects of large blasts on the brain are well understood, the effects of smaller blasts such as those that occur during military training are less understood.
Crabtree A, McEvoy C, Muench P, Ivory RA, Rodriguez J, Omer M, Charles T, Meabon JS.   +7 more
europepmc   +3 more sources

Functional and Structural Neuroimaging Correlates of Repetitive Low-Level Blast Exposure in Career Breachers. [PDF]

J Neurotrauma, 2020
Combat military and civilian law enforcement personnel may be exposed to repetitive low-intensity blast events during training and operations. Persons who use explosives to gain entry (i.e., breach) into buildings are known as "breachers" or dynamic entry personnel. Breachers operate under the guidance of established safety protocols, but despite these
Stone JR, Avants BB, Tustison NJ, Wassermann EM, Gill J, Polejaeva E, Dell KC, Carr W, Yarnell AM, LoPresti ML, Walker P, O'Brien M, Domeisen N, Quick A, Modica CM, Hughes JD, Haran FJ, Goforth C, Ahlers ST.   +18 more
europepmc   +3 more sources

Getting on the Same Page: Consolidating Terminology to Facilitate Cross-Disciplinary Health-Related Blast Research

Frontiers in Neurology, 2021
The consequences of blast exposure (including both high-level and low-level blast) have been a focal point of military interest and research for years. Recent mandates from Congress (e.g., National Defense Authorization Act for Fiscal Year 2018, section ...
Jennifer N. Belding, Jennifer N. Belding, Michael Egnoto, Robyn M. Englert, Robyn M. Englert, Shannon Fitzmaurice, Shannon Fitzmaurice, Cynthia J. Thomsen   +7 more
doaj   +1 more source

Elevated Axonal Protein Markers Following Repetitive Blast Exposure in Military Personnel

Frontiers in Neuroscience, 2022
Blast exposures that occur during training are common in military personnel; however, the biomarkers that relate to these subtle injuries is not well understood.
Rany Vorn, Rany Vorn, Rosanne Naunheim, Chen Lai, Chen Lai, Chelsea Wagner, Jessica M. Gill, Jessica M. Gill   +7 more
doaj   +1 more source