Results 61 to 70 of about 1,751 (155)

Misdiagnosis of narcolepsy [PDF]

, 2016
BACKGROUND: Narcolepsy is a chronic primary sleep disorder, characterized by excessive daytime sleepiness and sleep dysfunction with or without cataplexy.
American Academy of Sleep Medicine, American Academy of Sleep Medicine, BB Wilford, D Arand, EJ Mignot, Emily L Maschauer, I Morrison, I Morrison, Ian Morrison, Laura Dunne, LE Krahn, LM Trotti, MH Silber, MR Littner, MW Johns, Pallavi Patel, Renata L Riha, RM Benca, S Dzodzomenyo, WA Broughton   +19 more
core   +3 more sources

Spasmodic Dysphonia

World Journal of Otorhinolaryngology - Head and Neck Surgery, Volume 11, Issue 4, Page 548-567, December 2025.
ABSTRACT Spasmodic dysphonia is a laryngeal dystonia that can present as adductor, abductor, or mixed types, with or without tremor. The etiology is not understood fully. Comprehensive evaluation is required to establish the diagnosis. Treatments include voice therapy, medications, botulinum toxin injection, laryngeal surgery, deep brain stimulation ...
Aaron J. Jaworek, Robert T. Sataloff
wiley   +1 more source

Patients' perspective of the effectiveness and acceptability of pharmacological and non-pharmacological treatments of fibromyalgia. [PDF]

, 2018
Background and aims Fibromyalgia is a complex condition characterised by widespread pain, sleep disturbance, fatigue and cognitive impairment, with a global mean prevalence estimated at 2.7%.
Ashe, Simon, Furness, Penny, Haywood-Small, Sarah, Lawson, Kim, Steer, Michael, Taylor, Sophie   +5 more
core   +1 more source

Treatment interventions to maintain abstinence from alcohol in primary care:Systematic review and network meta-analysis [PDF]

, 2020
OBJECTIVE: To determine the most effective interventions in recently detoxified, alcohol dependent patients for implementation in primary care. DESIGN: Systematic review and network meta-analysis. DATA SOURCES: Medline, Embase, PsycINFO, Cochrane CENTRAL,
Cheng, Hung-yuan, Cowlishaw, Sean, Dawson, Sarah, Elbers, Roy G, Hickman, Matthew, Higgins, Julian P T, Kessler, David, Lingford-hughes, Anne, López-lópez, José A, Macarthur, Georgina J, Mcaleenan, Alexandra, Mcguinness, Luke A, Taylor, Abigail   +12 more
core   +3 more sources

Neuroendocrinology meets addiction: Emerging pharmacotherapies on the horizon

Journal of Internal Medicine, Volume 298, Issue 5, Page 392-423, November 2025.
Abstract Alcohol and other substance use disorders (ASUDs) are prevalent and major contributors to global morbidity and mortality. Their impact extends beyond the individual, imposing significant burdens on families, communities, healthcare systems, and society at large.
Anna Loften, Mehdi Farokhnia, Leandro F. Vendruscolo, Lorenzo Leggio   +3 more
wiley   +1 more source

Is Sodium Oxybate a Safe and Effective Treatment for Patients with Fibromyalgia [PDF]

, 2012
Objective: The objective of this systematic review is to determine whether or not Sodium Oxybate is a safe and effective treatment of pain and sleep-related symptoms of fibromyalgia.
Grandinette, Britanie A
core   +1 more source

Orexin Deficiency in Narcolepsy: Molecular Mechanisms, Clinical Phenotypes, and Emerging Therapeutic Frontiers

Brain and Behavior, Volume 15, Issue 10, October 2025.
Orexin deficiency drives narcolepsy Type 1, leading to excessive daytime sleepiness, cataplexy, and REM intrusions. This review highlights recent advances (2023–2025) in molecular mechanisms, diagnostics, and emerging orexin‐targeted therapies with the potential for disease modification.
Rameesha Rauf, Salwa Asif, Abdallah AlSaafeen, Kaviprada Geathaa Dhantapaani, Maryam Muhammad Nadeem, Zohra Kamran Rao, Aliya Shaju Shahul Hameed, Karthik Chintharala, Muhammad Faheem Anwar, Asad Ali Ahmed Cheema   +9 more
wiley   +1 more source

The Space–Time Organisation of Sleep Slow Oscillations as Potential Biomarker for Hypersomnolence

Journal of Sleep Research, Volume 34, Issue 5, October 2025.
ABSTRACT Research suggests that the spatial profile of slow wave activity (SWA) could be altered in hypersomnolence. Slow oscillations (SOs; 0.5–1.5 Hz), single waveform events contributing to SWA, can be labelled as Global, Frontal, or Local depending on their presentation on the scalp.
Mahmoud Alipour, Joseph Rausch, Sara C. Mednick, Jesse D. Cook, David T. Plante, Paola Malerba   +5 more
wiley   +1 more source

Dreaming of Better Treatments: Advances in Drug Development for Sleep Medicine and Chronotherapy

Journal of Sleep Research, Volume 34, Issue 5, October 2025.
ABSTRACT Throughout history, the development of new sleep medicines has been driven by progress in our understanding of the mechanisms underlying sleep. Ancient civilisations used their understanding of the sedative nature of natural herbs and compounds to induce sleep.
Brooke A. Prakash, Ishani Shah, Guohao Ni, Sridhar Vasudevan, Aarti Jagannath, Russell G. Foster   +5 more
wiley   +1 more source

In-field assessment of sodium oxybate effect in pediatric type 1 narcolepsy: An actigraphic study [PDF]

, 2018
Study Objectives: Sodium oxybate (SXB) is a GABAergic agent widely used as off-label treatment in pediatric type 1 narcolepsy (NT1). Here, we aimed at analyzing by wrist actigraphy the sleep/wake profile of NT1 children and adolescents in drug-na\uefve ...
Antelmi, Elena, Ferri, Raffaele, Filardi, Marco, Natale, Vincenzo, Pizza, Fabio, Plazzi, Giuseppe   +5 more
core   +1 more source