Results 41 to 50 of about 1,788 (174)

Symptom Severity and Treatment Satisfaction in Patients with Idiopathic Hypersomnia: The Real World Idiopathic Hypersomnia Outcomes Study (ARISE)

Nature and Science of Sleep, 2023
Logan Douglas Schneider,1 Joanne Stevens,2 Aatif M Husain,3 Diane Ito,4 Douglas S Fuller,5 Phyllis C Zee,6 Wayne Macfadden2 1Stanford University Sleep Medicine Center, Stanford University School of Medicine, Stanford, CA, USA; 2Global Medical Affairs ...
Schneider LD, Stevens J, Husain AM, Ito D, Fuller DS, Zee PC, Macfadden W   +6 more
doaj  

Association between objectively measured physical activity and opioid, hypnotic, or anticholinergic medication use in older people – data from the Physical Activity Cohort Scotland study [PDF]

, 2018
Background: Centrally acting medications cause cognitive slowing and incoordination, which could reduce older people’s physical activity levels. This association has not been studied previously.Objectives: To examine the association between opioid ...
A Moschny, A Zia, AM Rojo-Sanchís, BP Kolla, C Fox, CL Clarke, CL Clarke, Clare L. Clarke, CV Bostock, D Sumukadas, D Sumukadas, D Sumukadas, Department of Health, E Lowry, EJ Dansie, Falko F. Sniehotta, G Kochersberger, HT Taipale, IM Lee, JL Rudolph, K Richardson, KR Fox, L Pasina, LH Colbert, M Bonnefoy, MA Perry, MD Witham, ME McMurdo, MET McMurdo, Miles D. Witham, P Hendrick, Peter T. Donnan, PK Myint, R Heseltine, Scottish Government Model of Care Polypharmacy Working Group, SL Gray, Thenmalar Vadiveloo   +36 more
core   +2 more sources

Progressive Supranuclear Palsy and Corticobasal Degeneration: Pathophysiology and Treatment Options [PDF]

, 2016
There are currently no disease-modifying treatments for progressive supranuclear palsy (PSP) or corticobasal degeneration (CBD), and no approved pharmacological or therapeutic treatments that are effective in controlling their symptoms.
Andrew J. Lees, Huw R. Morris, Jonathan D. Rohrer, Ruth Lamb   +3 more
core   +1 more source

Narcolepsy and rapid eye movement sleep

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Since the first description of narcolepsy at the end of the 19th Century, great progress has been made. The disease is nowadays distinguished as narcolepsy type 1 and type 2. In the 1960s, the discovery of rapid eye movement sleep at sleep onset led to improved understanding of core sleep‐related disease symptoms of the disease (excessive ...
Francesco Biscarini, Lucie Barateau, Fabio Pizza, Giuseppe Plazzi, Yves Dauvilliers   +4 more
wiley   +1 more source

Therapeutic and toxic blood concentrations of nearly 1,000 drugs and other xenobiotics [PDF]

, 2012
Introduction: In order to assess the significance of drug levels measured in intensive care medicine, clinical and forensic toxicology, as well as for therapeutic drug monitoring, it is essential that a comprehensive collection of data is readily ...
Andresen, Hilke, Iwersen-Bergmann, Stefanie, Schmoldt, Achim, Schulz, Martin   +3 more
core   +1 more source

Dosing and transition characteristics in people with narcolepsy transitioning from sodium oxybate to low-sodium oxybate: Data from the real-world TENOR study

Sleep Medicine
The Transition Experience of persons with Narcolepsy taking Oxybate in the Real-world (TENOR) study assessed the real-world experience of people with narcolepsy switching from sodium oxybate (SXB) to low-sodium oxybate (LXB; 92 % less sodium than SXB).TENOR is a patient-centric, prospective, observational, virtual-format study.
Aatif M, Husain, Phyllis C, Zee, Eileen B, Leary, Douglas S, Fuller, Wayne, Macfadden, Shawn, Candler, Marisa, Whalen, Charles J, Bae   +7 more
openaire   +2 more sources

Parasomnias and sleep‐related movement disorders induced by drugs in the adult population: a review about iatrogenic medication effects

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Parasomnias and sleep‐related movement disorders (SRMD) are major causes of sleep disorders and may be drug induced. The objective of this study was to conduct a systematic review of the literature to examine the association between drug use and the occurrence of parasomnias and SRMD.
Sylvain Dumont, Vanessa Bloch, Agnès Lillo‐Lelouet, Christine Le Beller, Pierre A. Geoffroy, Marc Veyrier   +5 more
wiley   +1 more source

iSPHYNCS: Unsupervised Clustering in Questionnaires and Metadata Reveals Distinct Subtypes in the Narcolepsy Borderland

Journal of Sleep Research, EarlyView.
Study overview and clustering results in the iSPHYNCS cohort. Participant demographics are summarized in a baseline table. Questionnaire data and metadata were processed through an unsupervised clustering pipeline. A Sankey plot illustrates individual assignment across clusters by diagnostic group.
Rafael Morand, Livia Fregolente, Julia van der Meer, Elena S. Wenz, Annina Helmy, Lorenzo Brigato, Jan D. Warncke, Kseniia Zub, Ramin Khatami, Zhongxing Zhang, Sigrid von Manitius, Silvia Miano, Jens Acker, Mathias Strub, Ulf Kallweit, Gert Jan Lammers, Athina Tzovara, Claudio L. A. Bassetti, Stavroula Mougiakakou, Markus H. Schmidt   +19 more
wiley   +1 more source

Treatment of Essential Tremor: Are there Issues We are Overlooking? [PDF]

, 2012
Background: Essential tremor (ET) is one of the most common neurological diseases. Although a large number of medications have been tested, there are only two first-line medications, primidone and propranolol, which is a situation that has not changed in
Elan D. Louis
core   +1 more source

Implication of the thalamus in sleep alterations observed in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract Alzheimer's disease (AD), the most common neurodegenerative disorder, is frequently accompanied by sleep disturbances. Alterations of sleep, in both quality and quantity, contribute to the progression of AD neuropathology. The thalamus, through its diverse nuclei, plays a central role in sleep regulation and sleep‐dependent memory ...
Carla Burnet‐Merlin, Y. Audrey Hay, Aurélie Brécier   +2 more
wiley   +1 more source