Results 21 to 30 of about 1,788 (174)

Determination of gamma-hydroxybutyric acid in dried blood spots using a simple GC-MS method with direct 'on spot' derivatization [PDF]

, 2010
The objective of this study was the development of an accurate and sensitive method for the determination of gamma-hydroxybutyric acid (GHB) in dried whole blood samples using a GC-MS method.
Ingels, Ann-Sofie, Lambert, Willy, Stove, Christophe   +2 more
core   +1 more source

Narcolepsy: Pathophysiology, Diagnosis, Management, and Future Directions, a Narrative Review. [PDF]

Brain Behav
This visual summary outlines the pathophysiology of narcolepsy, driven by hypocretin loss, and details its clinical diagnosis, current management strategies, and the shift toward future disease‐modifying therapies like orexin agonists and immunomodulation.
Hastings NE, Abdi KE, Bibi F, Aslam B, Nuñez MR, Sherani MTR, Shadmani S, Alam U, Hassan VM, Hoor-E-Ainaa, Imran H, Hanna J, Sadat SH.   +12 more
europepmc   +2 more sources

Current treatments to counter sleep dysfunction as a pathogenic stimulus of fibromyalgia [PDF]

, 2016
Fibromyalgia is characterized by chronic widespread pain, fatigue and nonrestorative sleep. Polysomnography showed reduced short-wave sleep and abnormal alpha rhythms during nonrapid eye movement sleep in patients with fibromyalgia.
Choy, Ernest H.
core   +2 more sources

Efficacy of modified atkins ketogenic diet in chronic cluster headache. An open-label, single-arm, clinical trial [PDF]

, 2018
Introduction: Drug-resistant cluster headache (CH) is still an open clinical challenge. Recently, our group observed the clinical efficacy of a ketogenic diet (KD), usually adopted to treat drug-resistant epilepsies, on migraine.
Cherubino Di Lorenzo, Davide Di Lenola, Francesco Pierelli, Francesco Pierelli, Gianluca Coppola, Giorgio Di Lorenzo, Giulio Sirianni, Mariano Serrao, Maurizio Evangelista, Paolo Rossi   +9 more
core   +3 more sources

Novel Psychoactive Substances 14Recent Progress on Neuropharmacological Mechanisms of Action for Selected Drugs [PDF]

, 2017
A feature of human culture is that we can learn to consume chemical compounds, derived from natural plants or synthetic fabrication, for their psychoactive effects.
Boris B. , Quednow, Christian P. , Müller, Erich, Seifritz, Hassan, Zurina, Johannes, Kornhuber, Kasinather, B. Vicknasingam, Narayanan, Suresh, Oliver G., Bosch, Singh, Darshan   +8 more
core   +1 more source

Individualized Treatment Patterns for Patients with Narcolepsy Treated with Oxybate: A Clinical Practice Perspective

Nature and Science of Sleep, 2023
Asim Roy,1 Diane Ito,2 Susan Morris,3 Shawn Candler,4 Judi Profant,3 Charles Bae5 1Ohio Sleep Medicine Institute, Dublin, OH, USA; 2Stratevi LLC, Santa Monica, CA, USA; 3Jazz Pharmaceuticals, Palo Alto, CA, USA; 4Jazz Pharmaceuticals, Philadelphia, PA ...
Roy A, Ito D, Morris S, Candler S, Profant J, Bae C   +5 more
doaj  

Evaluation of the Effectiveness of the Risk Minimization Measures of Sodium Oxybate in the European Union

Drugs - Real World Outcomes, 2020
Background Sodium oxybate (Xyrem®), approved by the European Medicines Agency (EMA) for narcolepsy with cataplexy, is only available through risk mitigation programs due to potential adverse effects including respiratory and central nervous system ...
Alex Iranzo, Pedro Serralheiro, Jan-Christof Schuller, Anne-Françoise Schlit, Jürgen W. G. Bentz   +4 more
doaj   +1 more source

Present and Future of Central Disorders of Hypersomnolence. [PDF]

J Sleep Res
ABSTRACT Central disorders of hypersomnolence (CDH) are rare neurological conditions lumped by excessive daytime sleepiness (EDS) as primary complaint mostly arising at young age, including narcolepsy type 1 (NT1), narcolepsy type 2 (NT2), idiopathic hypersomnia (IH), and Kleine‐Levin syndrome (KLS). Advances in clinical and translational research have
Biscarini F, Barateau L, Pizza F, Plazzi G, Dauvilliers Y.   +4 more
europepmc   +2 more sources

Medical treatment of dystonia [PDF]

, 2016
Therapeutic strategies in dystonia have evolved considerably in the past few decades. Three major treatment modalities include oral medications, botulinum toxin injections and surgical therapies, particularly deep brain stimulation.
Pichet Termsarasab, Steven J. Frucht, Thananan Thammongkolchai   +2 more
core   +2 more sources

Reduced insular γ‐aminobutyric acid in fibromyalgia [PDF]

, 2012
Objective Recent scientific findings have reinvigorated interest in examining the role of γ‐aminobutyric acid (GABA), the major inhibitory central nervous system neurotransmitter, in chronic pain conditions.
Borsook, Craig, Edden, Goudet, Harris, Harris, Jasmin, Patel, Patel, Petzke, Russell, Singer, Stagg, Valdes, Wolfe, Wolfe   +15 more
core   +1 more source