Results 11 to 20 of about 8,676,773 (167)

Sodium Oxybate-Induced secondary mania with psychotic symptoms: a case report and literature review

European Psychiatry
Introduction Sodium oxybate, an effective treatment for narcolepsy-associated daytime sleepiness and cataplexy, has been extensively. Despite its therapeutic benefits, sodium oxybate is not without its risks, and adverse psychiatric effects have been ...
C. Cárdenes Moreno, S. Yelmo-Cruz, I. Pérez Sagaseta de Ilurdoz, J. J. Tascón-Cervera, G. P. González-Rodríguez, M. Gallego-Restrepo   +5 more
doaj   +2 more sources

Implications of Oxybate Dosing Regimen for Sleep, Sleep Architecture, and Disrupted Nighttime Sleep in Patients with Narcolepsy: A Commentary

Neurology and Therapy, 2023
Narcolepsy is associated with disrupted nighttime sleep (DNS). Sodium oxybate (SXB; Xyrem®), administered twice nightly, is indicated for the treatment of cataplexy and excessive daytime sleepiness in patients 7 years or older with narcolepsy.
Russell Rosenberg, Rogelio Braceras, Wayne Macfadden, Shawn Candler, Jed Black, Chad Ruoff   +5 more
doaj   +2 more sources

Comparative efficacy of sodium oxybate versus placebo on improvement of nighttime sleep in adult patients with narcolepsy: A systematic review and meta-analysis [PDF]

Sleep Medicine: X
Background: Narcolepsy, a central hypersomnolence disorder, disrupts sleep regulation. Sodium oxybate, a CNS (central nervous system) depressant, is widely used as a treatment, but there are surprisingly very few rigorous studies comparing its ...
Adina Arshad, Muhammad Abdul Muqtadir Qureshi, Muhammad Abdullah Masood, Hafiz Shahbaz Zahoor, Ayesha Nazakat, Anfal Fatima, Javed Iqbal   +6 more
doaj   +2 more sources

Individualized Treatment Patterns for Patients with Narcolepsy Treated with Oxybate: A Clinical Practice Perspective

Nature and Science of Sleep, 2023
Asim Roy,1 Diane Ito,2 Susan Morris,3 Shawn Candler,4 Judi Profant,3 Charles Bae5 1Ohio Sleep Medicine Institute, Dublin, OH, USA; 2Stratevi LLC, Santa Monica, CA, USA; 3Jazz Pharmaceuticals, Palo Alto, CA, USA; 4Jazz Pharmaceuticals, Philadelphia, PA ...
Roy A, Ito D, Morris S, Candler S, Profant J, Bae C   +5 more
doaj   +1 more source

Content Validity and Psychometric Evaluation of the Idiopathic Hypersomnia Severity Scale (IHSS) in Adults with Idiopathic Hypersomnia [PDF]

Nature and Science of Sleep
Junji Lin,1 Caitlyn Lowe,2 Benjamin Banderas,2 Patricia Chandler,1 Ethan Arenson,2 Alan L Shields,2 Susan Morris,1 Bhavini Srivastava,1 Yves Dauvilliers3,4 1Jazz Pharmaceuticals, Palo Alto, CA, USA; 2Adelphi Values, Boston, MA, USA; 3Sleep and Wake ...
Lin J, Lowe C, Banderas B, Chandler P, Arenson E, Shields AL, Morris S, Srivastava B, Dauvilliers Y   +8 more
doaj   +2 more sources

Criteria for Gauging Response to Sodium Oxybate for Narcolepsy [PDF]

, 2017
Our objective was to define responder criteria using an anchor-based approach for frequency of cataplexy attacks and excessive daytime sleepiness in narcolepsy patients undergoing sodium oxybate treatment. We used pooled data from two randomized, placebo-
Chinglin Lai (5169872), Terri E. Weaver (7931498), Alana D. Steffen (7931495)   +2 more
core   +6 more sources

Effectiveness and tolerability in people with narcolepsy transitioning from sodium oxybate to low-sodium oxybate: Data from the real-world TENOR study

Sleep Medicine, 2023
The Transition Experience of persons with Narcolepsy taking Oxybate in the Real-world (TENOR) study was conducted to provide real-world insight into the experience of people with narcolepsy switching from sodium oxybate (SXB) to low-sodium oxybate (LXB; 92% less sodium than SXB).TENOR is a patient-centric, prospective, observational, virtual-format ...
Charles J, Bae, Phyllis C, Zee, Eileen B, Leary, Douglas S, Fuller, Wayne, Macfadden, Shawn, Candler, Teresa L, Steininger, Aatif M, Husain   +7 more
openaire   +2 more sources

Sodium Oxybate: a Substitute for Alcohol?

European Psychiatry, 2022
Gamma-hydroxybutyrate (GHB) is a neurotransmitter found naturally in the human brain. Sodium oxybate (SO) is the sodium salt of GHB. In 2000 GHB was classified a Schedule I controlled substance, while SO became a Schedule III controlled substance for ...
A. Gual, H. López-Pelayo, P. Bruguera, L. Miquel   +3 more
doaj   +1 more source

Narcolepsy treatment: from exorcism and bloodletting to modern therapy with histamine receptor inverse agonists

Neurologijos seminarai, 2020
In this review article, we present the treatment of narcolepsy since ancient times when patients experiencing the phenomenon of incubus (today understood as sleep paralysis with hypnagogic or hypnopompic hallucinations) were “cured” during the sessions ...
E. Sakalauskaitė-Juodeikienė, R. Masaitienė   +1 more
doaj   +1 more source

The sodium in sodium oxybate: is there cause for concern? [PDF]

, 2020
Sodium oxybate (SO), the sodium salt of γ-hydroxybutyric acid, is one of the primary pharmacologic agents used to treat excessive sleepiness, disturbed nighttime sleep, and cataplexy in narcolepsy. The sodium content of SO ranges from 550 to 1640 mg&
Kushida, Clete A, Avidan, Alon Y
core   +1 more source