Results 61 to 70 of about 8,676,773 (167)

Improvements in daytime sleepiness and disrupted nighttime sleep with once-nightly sodium oxybate in people with narcolepsy type 1 and type 2: a plain language summary

Journal of Comparative Effectiveness Research
What is this summary about? This is a plain language summary of a published article in the journal Sleep. Narcolepsy is a sleep condition that has 2 different subtypes: narcolepsy type 1 and narcolepsy type 2. These are called NT1 and NT2 for short.
Yves Dauvilliers, Thomas Roth, Richard Bogan, Michael J Thorpy, Anne Marie Morse, Fèri Ascencion, Jennifer Gudeman   +6 more
doaj   +1 more source

Plasma total ghrelin and leptin levels in human narcolepsy and matched healthy controls: Basal concentrations and response to sodium oxybate [PDF]

, 2013
Contains fulltext : 149653.pdf (Publisher’s version ) (Closed access)STUDY OBJECTIVES: Narcolepsy is caused by a selective loss of hypocretin neurons and is associated with obesity. Ghrelin and leptin interact with hypocretin neurons to
Donjacour, CEHM Claire, Pijl, H., Donjacour, C.E., Roelfsema, F., Overeem, S Sebastiaan, Lammers, Gert Jan Gert, Roelfsema, Ferdinand, Frolich, M., Aziz, N Ahmad, Frölich, Marijke, Pardi, Daniel, Lammers, G.J., Aziz, N.A., Pijl, Hanno, Donjacour, C.E.H.M., Overeem, S., Pardi, D.   +16 more
core   +1 more source

Sodium Oxybate-Induced Sleep Driving and Sleep-Related Eating Disorder

, 2011
Hypnosedative-induced complex behaviors have gained increased attention in recent years as a potential complication of benzodiazepines and benzodiazepine-receptor agonist use.
Wallace, Douglas Mckay, Douglas Mckay Wallace, Shirin Shafazand, Tanisha Maze, Shafazand, Shirin, Maze, Tanisha   +5 more
core   +1 more source

A novel therapeutic agent, sodium oxybate, improves dystonic symptoms via reduced network-wide activity

, 2018
Oral medications for the treatment of dystonia are not established. Currently, symptoms of focal dystonia are managed with botulinum toxin injections into the affected muscles.
Blitzer, Andrew, Sichani, Azadeh Hamzehei, Simonyan, Kristina, Frucht, Steven J., Rumbach, Anna F.   +4 more
core   +1 more source

Feasibility of following up gamma-hydroxybutyric acid concentrations in sodium oxybate (Xyrem®)-treated narcoleptic patients using dried blood spot sampling at home : an exploratory study [PDF]

, 2013
Background: Gamma-hydroxybutyric acid (GHB), well known as a party drug, especially in Europe, is also legally used (sodium oxybate, Xyrem (R)) to treat a rare sleep disorder, narcolepsy with cataplexy.
Stove, ChristopheFW030019943480868010013931200000-0001-7126-348XF5DB63F4-F0ED-11E1-A9DE-61C894A0A6B4, Hertegonne, Katrien, Lambert, WillyUGent801000386037976994142964F3E79A2C-F0ED-11E1-A9DE-61C894A0A6B4, Lambert, Willy, Ingels, Ann-SofieUGent002003444868802000428149971946760795FAF14EEE-F0ED-11E1-A9DE-61C894A0A6B4, Ingels, Ann-Sofie, Hertegonne, KatrienGE35UZGent0019881226098020005684940000-0001-6796-78711BD05ECA-F0EE-11E1-A9DE-61C894A0A6B4, Stove, Christophe   +7 more
core   +1 more source

Long-term efficacy and safety of low-sodium oxybate in an open-label extension period of a placebo-controlled, double-blind, randomized withdrawal study in adults with idiopathic hypersomnia. [PDF]

J Clin Sleep Med, 2023
Morse AM, Dauvilliers Y, Arnulf I, Thorpy MJ, Foldvary-Schaefer N, Chandler P, Chen A, Hickey L, Black J, Bogan RK.   +9 more
europepmc   +1 more source

Once-nightly sodium oxybate (FT218) improved symptoms of disrupted nighttime sleep in people with narcolepsy: a plain language summary

, 2023
WHAT IS THIS SUMMARY ABOUT? This is a plain language summary of a published article in the journal CNS Drugs. Narcolepsy is a rare sleep condition. Most people with narcolepsy experience disrupted nighttime sleep and have poor quality of sleep. Sometimes
Kushida, Clete A, Thorpy, Michael J, Roth, Thomas, Horsnell, Matthew, Gudeman, Jennifer   +4 more
core   +1 more source

Weight changes during treatment with low-sodium oxybate in two phase 3 clinical studies in participants with narcolepsy or idiopathic hypersomnia

Sleep Medicine
Low-sodium oxybate (LXB) is approved in the United States for treating cataplexy or excessive daytime sleepiness in patients aged ≥7 years with narcolepsy and idiopathic hypersomnia in adults. This post hoc analysis evaluated LXB effects on weight in patients with narcolepsy or idiopathic hypersomnia from two phase 3 studies.Adults with narcolepsy with
Nancy, Foldvary-Schaefer, Roman, Skowronski, Patricia, Chandler, Douglas S, Fuller, Teresa L, Steininger, Thomas J, Measey, Shawn, Candler, Marisa, Whalen, Yves, Dauvilliers   +8 more
openaire   +2 more sources

Low-Sodium Oxybate Improved Symptoms in Adults with Narcolepsy with Cataplexy: A Plain Language Summary of Publication

Future Neurology, 2023
Richard K Bogan, Nancy Foldvary-Schaefer, Wayne Macfadden, Monica Gow, Michael J Thorpy   +4 more
openaire   +1 more source

Efficacy and safety of sodium oxybate in alcohol-dependent patients with a very high drinking risk level

, 2018
International audienceMedication development for alcohol relapse prevention or reduction of consumption is highly challenging due to meth-odological issues of pharmacotherapy trials.
van denBrink W, Simon N, Gual, A., Lesch, Otto-Michael, Söderpalm, Bo,, Walter, Henriette, Perney P, Walter, H., Dematteis M, Aubin HJ, Caputo F, Sommer WH, Rehm, Jurgen, van den Brink, Wim, Paille, François, Rehm, J. rgen, Walter H, Spanagel, Rainer, Reynaud, M., Lesch OM, Rehm, J., Mann, Rainer, Benyamina, A., Mann, Karl, Paille F, Söderpalm B, Benyamina, Amine, Nutt, David, Perney, Pascal, Nutt, D., van den Brink, W., Paille, F., Caputo, Fabio, Simon, Nicolas, Spanagel R, Nutt D, Sommer, Wolfgang H., Lesch, O. M., Reynaud, Michel, Aubin, Henri-Jean, Maremmani, Icro, Gual, Antoni, Addolorato G, Söderpalm, Bo, Gual A, Caputo, F., Aubin, H. J., Benyamina A, Maremmani I, Dematteis, M., Reynaud M, Mann, K., Perney, P., Sommer, W. H., Addolorato, Giovanni, Rehm J, Addolorato, G., Mann K, Spanagel, R., Maremmani, I., Simon, N., Addolorato G., Mann, Wolfgang, Dematteis, Maurice, Caputo F.   +64 more
core   +1 more source