Results 51 to 60 of about 8,676,773 (167)

The role of sodium oxybate in idiopathic hypersomnia: A case report showing improvement of excessive daytime sleepiness and reduced symptoms

, 2023
Our aim is to report the clinical profile and outcome of patients diagnosed with idiopathic hypersomnia (IH). Idiopathic hypersomnolence is a complex, debilitating, and uncommon sleep disorder manifested mainly by chronic excessive daytime ...
Patel, Palak, Kharel, Kirti K, Akhtar, Jamshaid, Vera Ricaurte, Michael, Sundaram, Akshay, Kagzi, Mohammad   +5 more
core   +1 more source

Towards Mechanism‐Informed Treatments for Mental Health

Journal of Neurochemistry, Volume 170, Issue 5, May 2026.
Neuropsychiatric disorders impose a major global health burden, and current treatments, which historically mostly targeted dopamine and serotonin dysfunctions, often provide only partial, symptomatic relief. This review highlights emerging evidence that additional neuromodulator systems, including acetylcholine, norepinephrine, and endocannabinoids ...
Iker Bengoetxea de Tena, Farhanah Nabilah Sallie, Arvie Rodriguez Abiero, Beatrice Rizzi, Leandro Gabriel Champarini, Elisa Corti, Gianluca Masella, Ariel L. Dunn, Luisa Bandeira Binder, Tyler J. Wenzel, Agustin I. Robles, Roberta G. Anversa, Cécilia Tremblay, Aliance Romain Fokoua, Randriely Merscher Sobreira de Lima, Mateus D'Ávila, Trang T. T. Truong, Jessica C. Pierce, Rui S. Rodrigues, Luis Dinamarca‐Villarroel, Felipe Borges Almeida, Aino‐Kaisa Piironen, Andrey F. L. Aguiar, Andrés M. Jaramillo, Lucas Santos, Anja de Lange, David J. Nutt, Andrew J. Lawrence   +27 more
wiley   +1 more source

Implication of the thalamus in sleep alterations observed in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract Alzheimer's disease (AD), the most common neurodegenerative disorder, is frequently accompanied by sleep disturbances. Alterations of sleep, in both quality and quantity, contribute to the progression of AD neuropathology. The thalamus, through its diverse nuclei, plays a central role in sleep regulation and sleep‐dependent memory ...
Carla Burnet‐Merlin, Y. Audrey Hay, Aurélie Brécier   +2 more
wiley   +1 more source

Long-Term Effect of Sodium Oxybate (Xyrem®) in Spasmodic Dysphonia with Vocal Tremor [PDF]

, 2013
Background: Symptoms of spasmodic dysphonia (SD) are usually managed successfully with botulinum toxin injections. Vocal tremor (VT), which accompanies SD, has a poor response to this treatment.Case Report: We report a case of a female with SD and VT who
Simonyan, Kristina, Steven J. Frucht, Frucht, Steven J., Kristina Simonyan   +3 more
core   +1 more source

Treatment approaches in posthypoxic myoclonus: A narrative review with expert opinion

Epilepsia, Volume 67, Issue 3, Page 1049-1065, March 2026.
Abstract Acute posthypoxic myoclonus (PHM) is a neurological complication that typically emerges within 12–48 h following cardiac arrest, often in comatose patients. It can present as generalized, multifocal, or focal myoclonus and has traditionally been associated with poor prognosis.
Marina Romozzi, Federico Tosto, David García‐Azorín, Luigi Francesco Iannone, Catello Vollono, Paolo Calabresi, Juan Luis Alcala‐Zermeno, Michael R. Sperling   +7 more
wiley   +1 more source

The pharmacokinetics of once-nightly controlled- release Sodium Oxybate (FT218): overview of results from four phase 1 studies

, 2019
Introduction: Sodium oxybate is an effective treatment for excessive daytime sleepiness and cataplexy in patients with narcolepsy. The approved effective doses of sodium oxybate are 6, 7.5 and 9 g per night, divided in two doses - the first taken at ...
Thorpy, M, Winkelman, J, Monteith, D, Corser, B, Dubow, J, Roth, Thomas, Grassot, J   +6 more
core   +1 more source

Emergency department presentations, hospitalisations and police seizure data related to gamma‐hydroxybutyrate (GHB) in New South Wales, Australia, from 2015 to 2024

Addiction, Volume 121, Issue 2, Page 305-315, February 2026.
Abstract Background and aims Gamma‐hydroxybutyrate (GHB) is an endogenous neurochemical and illicit synthetic drug. Its precursors, gamma‐butyrolactone (GBL) and 1,4‐butanediol (1,4‐BD), are often used as substitutes. We aimed to describe GHB‐related harms in New South Wales (NSW), Australia.
Krista J. Siefried, Janette L. Smith, Christine A. Harvey, Anthony Nedanoski, Jared A. Brown, Una Cullinan, Nadine Ezard, Thanjira Jiranantakan, Darren M. Roberts, Jonathan Brett   +9 more
wiley   +1 more source

Expanding the Genetic and Phenotypic Spectrum of DYT‐VPS16: The Importance of Splice‐Site Variants

Movement Disorders, Volume 41, Issue 1, Page 84-94, January 2026.
Abstract Background DYT‐VPS16, an early‐onset isolated dystonia caused by variants in the VPS16 gene, has been reported in fewer than 70 patients. Methods We explored the clinical and genotypic spectrum of DYT‐VPS16 by investigating early‐onset dystonia patients with VPS16 variants discovered in our large Biodatabank and through gene‐matching ...
Ana Westenberger, Edgard Verdura, Mandy Radefeldt, Leslie E. Sanderson, Kornelia Tripolszki, Anna Marcé‐Grau, Ana Cazurro‐Gutiérrez, Anita Nikoncuk, Rebecca Herzog, Ruslan Al‐Ali, Mariana Ferreira, Ligia S. Almeida, Tainá Regina Damaceno Silveira, Suliman Khan, Raphael Doyle Maia, Péter Klivényi, András Salamon, Volkan Baltaci, Asli Subasioglu, Jeanette Prada‐Arismendy, Goran Čuturilo, Sebastian Loens, Vera Tadic, Isabelle Maystadt, Deniz Karadurmus, Barbara Leube, Jonathan De Winter, Alice Monticelli, Liesbeth De Waele, Jonathan Baets, Mateja Vinkšel, Aleš Maver, Lorena Tschopp, Gabriela Ziegler, Ana Sanguinetti, Katja Lohmann, Tahsin Stefan Barakat, Peter Bauer, Belén Perez‐Dueñas, Aida M. Bertoli‐Avella   +39 more
wiley   +1 more source

Effects of oxybate dose and regimen on disrupted nighttime sleep and sleep architecture

International audienceMany components of sleep are disrupted in patients with narcolepsy, including sleep quality, sleep architecture, and sleep stability (ie, frequent awakenings/arousals and frequent shifts from deeper to lighter stages of sleep ...
Dauvilliers, Yves, Plazzi, Giuseppe, Roth, Thomas, Black, Jed, Bogan, Richard, K   +4 more
core   +3 more sources

Clinical applications of sodium oxybate (GHB): from narcolepsy to alcohol withdrawal syndrome [PDF]

, 2015
Gamma-hydroxybutyrate (GHB) is a short chain fatty acid endogenously produced within the central nervous system (CNS) and acts as a precursor and metabolite of the inhibitory neurotransmitter γ-aminobutyric acid (GABA).
KYRIAKOU, CHRYSTALLA, NAPOLETANO, SIMONA, ZAAMI, Simona, BUSARDO', FRANCESCO PAOLO, MARINELLI, Enrico   +4 more
core   +1 more source