Results 51 to 60 of about 1,788 (174)

Chronic widespread musculoskeletal pain, fatigue, depression and disordered sleep in chronic post-SARS syndrome; a case-controlled study [PDF]

, 2011
Background The long term adverse effects of Severe Acute Respiratory Syndrome (SARS), a viral disease, are poorly understood. Methods Sleep physiology, somatic and mood ...
Harvey Moldofsky, John Patcai
core   +3 more sources

Treatment approaches in posthypoxic myoclonus: A narrative review with expert opinion

Epilepsia, Volume 67, Issue 3, Page 1049-1065, March 2026.
Abstract Acute posthypoxic myoclonus (PHM) is a neurological complication that typically emerges within 12–48 h following cardiac arrest, often in comatose patients. It can present as generalized, multifocal, or focal myoclonus and has traditionally been associated with poor prognosis.
Marina Romozzi, Federico Tosto, David García‐Azorín, Luigi Francesco Iannone, Catello Vollono, Paolo Calabresi, Juan Luis Alcala‐Zermeno, Michael R. Sperling   +7 more
wiley   +1 more source

Pathophysiological Models of Hypersomnolence Associated With Depression

Biological Psychiatry Global Open Science
Up to 25% of patients with depression experience hypersomnolence (e.g., excessive daytime sleepiness, hypersomnia, and/or sleep inertia), which is associated with treatment resistance, overall poorer outcomes, and safety concerns while driving ...
Christophe Moderie, Diane B. Boivin
doaj   +1 more source

TRIPS implementation and secondary pharmaceutical patenting in Brazil and India [PDF]

, 1978
This article compares national approaches toward secondary pharmaceutical patents. Because secondary patents can extend periods of exclusivity and delay generic competition, they can raise prices and reduce access to medicines. Little is known about what
Bhaven N. Sampat, Kenneth C. Shadlen, T Amin, M Basso, ER Berndt, P Drahos, P Drahos, R Falvey, R Falvey, J Farrell, KM Gopakumar, CS Hemphill, CS Hemphill, CS Hemphill, L Howard, O Ivus, A Kapczynski, A Kapczynski, VYM Kunisawa, MK Kyle, S La Croix, M Lemley, M Liu, J-F Morin, WG Park, Y Qian, BN Sampat, FM Scherer, A Sengupta, KC Shadlen, KC Shadlen, CM Sweet, N Vernaz   +32 more
core   +1 more source

Emergency department presentations, hospitalisations and police seizure data related to gamma‐hydroxybutyrate (GHB) in New South Wales, Australia, from 2015 to 2024

Addiction, Volume 121, Issue 2, Page 305-315, February 2026.
Abstract Background and aims Gamma‐hydroxybutyrate (GHB) is an endogenous neurochemical and illicit synthetic drug. Its precursors, gamma‐butyrolactone (GBL) and 1,4‐butanediol (1,4‐BD), are often used as substitutes. We aimed to describe GHB‐related harms in New South Wales (NSW), Australia.
Krista J. Siefried, Janette L. Smith, Christine A. Harvey, Anthony Nedanoski, Jared A. Brown, Una Cullinan, Nadine Ezard, Thanjira Jiranantakan, Darren M. Roberts, Jonathan Brett   +9 more
wiley   +1 more source

Source inference of exogenous gamma-hydroxybutyric acid (GHB) administered to humans by means of carbon isotopic ratio analysis: novel perspectives regarding forensic investigation and intelligence issues [PDF]

, 2018
γ-Hydroxybutyric acid (GHB) is an endogenous short-chain fatty acid popular as a recreational drug due to sedative and euphoric effects, but also often implicated in drug-facilitated sexual assaults owing to disinhibition and amnesic properties.
Marclay, François, Saudan, Christophe, Saugy, Martial, Tafti, Mehdi, Vienne, Julie   +4 more
core  

Fibromyalgia syndrome: an overview of pathophysiology, diagnosis and management [PDF]

, 2012
Fibromyalgia Syndrome (FMS) is a chronic condition causing pain, stiffness, and tenderness of the muscles, tendons, and joints. It is also characterized by restless sleep, tiredness, fatigue, anxiety, depression, and disturbances in bowel functions.
Jahan, Firdous, Nanji, Kashmira, Qasim, Rizwan, Qidwai, Waris   +3 more
core   +2 more sources

Expanding the Genetic and Phenotypic Spectrum of DYT‐VPS16: The Importance of Splice‐Site Variants

Movement Disorders, Volume 41, Issue 1, Page 84-94, January 2026.
Abstract Background DYT‐VPS16, an early‐onset isolated dystonia caused by variants in the VPS16 gene, has been reported in fewer than 70 patients. Methods We explored the clinical and genotypic spectrum of DYT‐VPS16 by investigating early‐onset dystonia patients with VPS16 variants discovered in our large Biodatabank and through gene‐matching ...
Ana Westenberger, Edgard Verdura, Mandy Radefeldt, Leslie E. Sanderson, Kornelia Tripolszki, Anna Marcé‐Grau, Ana Cazurro‐Gutiérrez, Anita Nikoncuk, Rebecca Herzog, Ruslan Al‐Ali, Mariana Ferreira, Ligia S. Almeida, Tainá Regina Damaceno Silveira, Suliman Khan, Raphael Doyle Maia, Péter Klivényi, András Salamon, Volkan Baltaci, Asli Subasioglu, Jeanette Prada‐Arismendy, Goran Čuturilo, Sebastian Loens, Vera Tadic, Isabelle Maystadt, Deniz Karadurmus, Barbara Leube, Jonathan De Winter, Alice Monticelli, Liesbeth De Waele, Jonathan Baets, Mateja Vinkšel, Aleš Maver, Lorena Tschopp, Gabriela Ziegler, Ana Sanguinetti, Katja Lohmann, Tahsin Stefan Barakat, Peter Bauer, Belén Perez‐Dueñas, Aida M. Bertoli‐Avella   +39 more
wiley   +1 more source

Prolonged Detection of GHB Intake in Urine: Are We Finally There?

Drug Testing and Analysis, Volume 17, Issue 12, Page 2429-2446, December 2025.
In a randomised placebo‐controlled trial with 30 volunteers, urinary LC‐MS/MS analysis demonstrated that a tentative GHB‐pentose conjugate remained elevated in urine up to 72 h post‐administration. This biomarker showed clear distinction from placebo and may offer extended detection compared to GHB itself, representing a significant step forward in ...
Kathrine B. Faldborg, Jørgen B. Hasselstrøm, Thomas Kraemer, Charlotte U. Andersen, Andrea E. Steuer   +4 more
wiley   +1 more source

Growing Up with Type 1 narcolepsy: Its anthropometric and endocrine features [PDF]

, 2016
Study Objectives: To evaluate the effect of type 1 narcolepsy (NT1) on anthropometric and endocrine features in childhood/adolescence, focusing on patterns and correlates of weight, pubertal development, and growth in treated and untreated patients ...
Balsamo, Antonio, Bernardi, Filippo, Gennari, Monia, Pizza, Fabio, Plazzi, Giuseppe, Ponziani, Virginia   +5 more
core   +1 more source