Results 31 to 40 of about 11,362,691 (296)

Receptor-mediated low density lipoprotein catabolism in man.

Journal of Lipid Research, 1979
Binding of human low density lipoproteins (LDL) to their specific receptor on cultured cells can be inhibited by treatment with 1,2-cyclohexanedione which blocks a number of functionally significant arginyl residues on the apolipoprotein.
J Shepherd, S Bicker, A R Lorimer, C J Packard   +3 more
doaj   +1 more source

A macrophage receptor that recognizes oxidized low density lipoprotein but not acetylated low density lipoprotein

Journal of Biological Chemistry, 1989
The formation of cholesterol-loaded macrophage foam cells in arterial tissue may occur by the uptake of modified lipoproteins via the scavenger receptor pathway. The macrophage scavenger receptor, also called the acetylated low density lipoprotein (Ac-LDL) receptor, has been reported to recognize Ac-LDL as well as oxidized LDL species such as ...
C P, Sparrow, S, Parthasarathy, D, Steinberg   +2 more
openaire   +2 more sources

The characterisation of the ectodomain shedding of the low density lipoprotein receptor [PDF]

, 2009
Includes abstract. Includes bibliographical references (leaves 142-155)
Parker, Ayesha
core   +1 more source

Effect of hypocholesterolemic doses of 17 alpha-ethinyl estradiol on cholesterol balance in liver and extrahepatic tissues.

Journal of Lipid Research, 1996
This study was performed to investigate the effects of 17 alpha-ethinyl estradiol, a potent hypocholesterolemic agent at pharmacological doses, on cholesterol balance in the liver and extrahepatic tissues of the rat in vivo.
M Bertolotti, D K Spady
doaj   +1 more source

The Role of Calcium in Lipoprotein Release by the Low-Density Lipoprotein Receptor [PDF]

Biochemistry, 2009
The LDL receptor (LDLR) mediates efficient endocytosis of VLDL, VLDL remnants, and LDL. As part of the uptake process, the LDLR releases lipoproteins in endosomes. Released lipoproteins are subsequently trafficked to lysosomes for degradation, while the LDLR recycles back to the cell surface for further rounds of uptake.
Zhenze, Zhao, Peter, Michaely
openaire   +2 more sources

Overexpression of low-density lipoprotein receptor prevents neurotoxic polarization of astrocytes via inhibiting NLRP3 inflammasome activation in experimental ischemic stroke

Neural Regeneration Research
Neurotoxic astrocytes are a promising therapeutic target for the attenuation of cerebral ischemia/reperfusion injury. Low-density lipoprotein receptor, a classic cholesterol regulatory receptor, has been found to inhibit NLR family pyrin domain ...
Shuai Feng, Juanji Li, Tingting Liu, Shiqi Huang, Xiangliang Chen, Shen Liu, Junshan Zhou, Hongdong Zhao, Ye Hong   +8 more
doaj   +1 more source

A dot-blot assay for the low density lipoprotein receptor.

Journal of Lipid Research, 1986
We describe a new method for detecting the interaction of low density lipoprotein with its receptor using unmodified nitrocellulose as support for membrane protein. The method is specific and sensitive down to 3 micrograms of membrane protein.
F M Maggi, A L Catapano
doaj   +1 more source

MEDI6012: Recombinant Human Lecithin Cholesterol Acyltransferase, High‐Density Lipoprotein, and Low‐Density Lipoprotein Receptor–Mediated Reverse Cholesterol Transport

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background MEDI6012 is recombinant human lecithin cholesterol acyltransferase, the rate‐limiting enzyme in reverse cholesterol transport. Infusions of lecithin cholesterol acyltransferase have the potential to enhance reverse cholesterol transport and ...
Richard T. George, Liron Abuhatzira, Susan M. Stoughton, Sotirios K. Karathanasis, Dewei She, ChaoYu Jin, Nicholas A. P. S. Buss, Rebecca Bakker‐Arkema, Emily L. Ongstad, Michael Koren, Boaz Hirshberg   +10 more
doaj   +1 more source

Italian Multicenter Study on Low-Density Lipoprotein Apheresis Working Group 2009 Survey

, 2013
We present results of the second survey of the Italian Multicenter Study on Low-Density Lipoprotein Apheresis (IMSLDLa-WG/2). The study involved 18 centers in 2009, treating 66 males and 35 females, mean age 47 +/- 18 years.
MOROZZI, CLAUDIA, STEFANUTTI, Claudia, DI GIACOMO, SERAFINA, The Italian Multicenter Study O. N. Low Density Lipoprotein Apheresis Working Group   +3 more
core   +1 more source

Structure of the hamster low density lipoprotein receptor gene.

Journal of Lipid Research, 1992
The metabolism of low density lipoprotein (LDL) in the hamster is substantially similar to that of the human. To extend the usefulness of the hamster as an experimental model, the hamster LDL receptor gene was isolated and characterized.
RW Bishop
doaj   +1 more source