Results 121 to 130 of about 1,978,744 (337)

Phase Diagrams of Smart Copolymers Poly(N-isopropylacrylamide) and Poly(sodium acrylate)

The Scientific World Journal, 2014
The phase behavior of linear poly(N-isopropylacrylamide) (PNIPA), linear copolymer poly(N-isopropylacrylamide) and poly(sodium acrylate) (PNIPA-SA), and chemically cross-linked PNIPA in water has been determined by temperature modulated differential ...
Iwona Zarzyka, Maria Laura Di Lorenzo, Marek Pyda   +2 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Tuning the stimuli-responsive properties of poly(ionic liquid)s [PDF]

, 2015
Poly(Ionic Liquid)s (PILs) are a class of ionic liquids that feature polymerizable groups in either the cation, the anion or both. PILs can be used in various applications, including solid ion conductors or for CO2 absorption.
Diamond, Dermot, Florea, Larisa, Tudor, Alexandru   +2 more
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Development of Novel N-isopropylacrylamide (NIPAAm) Based Hydrogels with Varying Content of Chrysin Multiacrylate

Gels, 2017
A series of novel temperature responsive hydrogels were synthesized by free radical polymerization with varying content of chrysin multiacrylate (ChryMA).
Shuo Tang, Martha Floy, Rohit Bhandari, Thomas Dziubla, J. Zach Hilt   +4 more
doaj   +1 more source

Free convection boundary layers driven by exothermic surface reactions: critical ambient temperatures

, 1995
A model for the free convection boundary-layer flow near a forward stagnation point driven by heating from a surface on which there is a catalytic reaction is discussed.
Chaudhary, M.A., Liñán Martínez, Amable, Merkin, J.H.   +2 more
core  

On the Molecular Origin of the Cooperative Coil-to-globule Transition of Poly(N-isopropylacrylamide) in Water

, 2018
By means of atomistic molecular dynamics simulations we investigate the behaviour of poly(N-isopropylacrylamide), PNIPAM, in water at temperatures below and above the lower critical solution temperature (LCST), including the undercooled regime.
Chiessi, E., Tavagnacco, L., Zaccarelli, E.   +2 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Effect of polymer concentration on the lifetime and transmittance behavior of a self-oscillating polymer chain with a high lower critical solution temperature

MATEC Web of Conferences, 2017
In this study, we investigated the lifetime and self-oscillating behavior of a polymer chain with a high lower critical solution temperature (LCST). The polymer chain comprised 4-vinyl-4´-methyl-2,2´-bipyridinebis(2,2´-bipyridine)bis(hexafluorophosphate)
Nakazumi Tomoka, Hara Yusuke
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source