Results 71 to 80 of about 1,776,297 (283)

Tunable, Temperature-Responsive Polynorbornenes with Side Chains Based on an Elastin Peptide Sequence [PDF]

, 2009
Random copolymers made by living ring-opening metathesis polymerization of norbornene monomers containing either the elastin peptide sequence -(VPGVG)- or pentaethylene glycol (see scheme; Mes=mesityl, pyr=pyridine) exhibit a lower critical solution ...
Conrad, Rosemary M., Grubbs, Robert H.
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

LCST-phase behavior and complexation with water of an ionic liquid incorporating the 5-phenyltetrazolate anion [PDF]

, 2017
The use of 5-phenyltetrazole, a bioisostere of benzoic acid, as an anion source to prepare an ionic liquid is described for the first time. Tetrabutylphosphonium 5-phenyltetrazolate undergoes phase separation from water with lower critical solution ...
Allen, Ando, Balasubramanian, Ballatore, Bonhôte, Boros, Bradley, Brandt, Copp, Davidson, Dolomanov, Domańska, Domańskaa, Endres, Ewing, Fowler, Freire, Garcia, Gutowski, Huddleston, Ignat′ev, Jeffrey, Joshi, Katritzky, Kohno, Kohno, Królikowska, Letcher, McMullan, Nakayama, Passos, Qiao, Renon, Rodríguez, Saita, Seddon, Seo, Sheldrick, Strechan, Swatloski, Trindade, Zhao   +41 more
core   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

A Fluorescent Thermometer Based on a Pyrene-Labeled Thermoresponsive Polymer

Sensors, 2010
Thermoresponsive polymers that undergo a solubility transition by variation of the temperature are important materials for the development of ‘smart’ materials.
Ulrich S. Schubert, Richard Hoogenboom, Christian Pietsch, Antje Vollrath   +3 more
doaj   +1 more source

End-group functionalization of poly(2-oxazoline)s using methyl bromoacetate as initiator followed by direct amidation [PDF]

, 2019
Poly(2-alkyl/aryl-2-oxazoline)s (PAOx) are an alluring class of polymers for many applications due to the broad chemical diversity that is accessible for these polymers by simply changing the initiator, terminating agent and the monomer(s) used in their ...
Arys, Koen, Glassner, Mathias, Hoogenboom, Richard, Podevyn, Annelore, Retamero De La Rosa, Victor   +4 more
core   +2 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Conjugates of methylated cyclodextrin derivatives and hydroxyethyl starch (HES): Synthesis, cytotoxicity and inclusion of anaesthetic actives

Beilstein Journal of Organic Chemistry, 2014
The mono-6-deoxy-6-azides of 2,6-di-O-methyl-β-cyclodextrin (DIMEB) and randomly methylated-β-cyclodextrin (RAMEB) were conjugated to propargylated hydroxyethyl starch (HES) by Cu+-catalysed [2 + 3] cycloaddition.
Lisa Markenstein, Antje Appelt-Menzel, Marco Metzger, Gerhard Wenz   +3 more
doaj   +1 more source

Superconductivity at 23 K in Pt doped BaFe2As2 single crystals

, 2010
We report superconductivity in single crystals of the new iron-pnictide system BaFe1.9Pt0.1As2 grown by a self-flux solution method and characterized via x-ray, transport, magnetic and thermodynamic measurements.
Alireza P L, Bud’ko S L, Cheng P, Johnpierre Paglione, K Kirshenbaum, Li L J, N P Butch, P Y Zavalij, Park T, Ren Z-A, S R Saha, Saha S R, T Drye, Wang X F, Zhu X   +14 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source