Results 111 to 120 of about 74,325 (301)

LOX-1 release in exosomes.

, 2015
HEK-293#19 cells stably expressing LOX-1 were treated with filipin (5μM) and glimepiride (5μM) for 15, 30 and 60 min. Total protein extract (5μg) was loaded as a positive internal control of electrophoretic mobility (Extr.).
Silvia Biocca (83964), Giulia Vindigni (735910), Barbara Testa (817478), Magda Gioia (605480), Sofia Raniolo (817479), Giovanni Francesco Fasciglione (817480), Massimiliano Coletta (173635)   +6 more
core   +1 more source

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source

Evaluating the Utility of RNAseq in Prenatal Diagnostics: Expression Profiles of Cultured Chorionic Villus and Amniotic Fluid Samples

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective While RNAseq has enhanced variant interpretation in postnatal cases, its potential in the prenatal setting remains underexplored. This study investigates the utility of RNAseq in prenatal diagnostics by analyzing the expression profiles of cultured chorionic villus samples (cCVS) and amniotic fluid (cAF) samples. Methods We performed
Maria C. Vladoiu, Sen Zhao, Roni Zemet, Christian M. Parobek, Jefferson Cruz Sinson, Stacy Tankersley, Ignatia B. Van den Veyver, Pengfei Liu   +7 more
wiley   +1 more source

Current Cell/Organoid and Animal Models for Primary Sclerosing Cholangitis

Portal Hypertension &Cirrhosis, EarlyView.
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease with limited therapeutic options and a marked risk of progression to biliary fibrosis, cirrhosis, and malignancy. Progress in PSC research has been hindered by the lack of models that faithfully recapitulate the complex biliary microenvironment and disease heterogeneity ...
Qigu Yao, Sheng Cheng, Qiaoling Pan, Jiong Yu, Hongcui Cao   +4 more
wiley   +1 more source

Drought stress modulates indirect defense via bottom‐up effects in tomato and wheat

Pest Management Science, EarlyView.
Different water regimes can have a significant impact on plant morphology and defense pathways in tomato and wheat, triggering multiple olfactory choices in biocontrol agents of key insect pests. These findings could be used to implement biocontrol strategies within the IPM context under a changing climate scenario.
Mariangela Milordo, Eya Ben Hmad, Maria Flavia Pitruzzello, Carmelo Cavallaro, Giuseppe Massimino Cocuzza, Lucia Zappalà, Peng Han, Antonio Biondi, Michele Ricupero   +8 more
wiley   +1 more source

Isothiocyanates as Ferroptosis Inducers to Promote Cancer Cell Death

Phytotherapy Research, EarlyView.
ABSTRACT Cancer remains a leading cause of global mortality, with the therapeutic efficacy of anticancer drugs often hampered by late diagnosis and the development of chemotherapy resistance. Ferroptosis is an iron‐dependent form of regulated non‐apoptotic cell death driven by lipid peroxidation.
Valentina Citi, Renda Chahna, Francesca Maffei, Alma Martelli, Vincenzo Calderone, Carmela Fimognari, Eleonora Turrini   +6 more
wiley   +1 more source

Responsive nitric oxide‐releasing antibacterial materials for biofilm‐associated infections: Mechanisms, design strategies, and applications

Responsive Materials, EarlyView.
This review summarizes the recent progress in responsive NO‐releasing materials and their applications in biofilm‐associated infectious diseases. The design principles and response mechanisms are given to provide inspiration toward the future development of multi‐responsive NO‐releasing materials.
Wenyue Sun, Meiqi Li, Di Nan, Jiaqi Zhao, Yu Chen, Yao Gao, Shichen Zhang, Kirsten L. Van Landuyt, Manlin Qi   +8 more
wiley   +1 more source

Atomization and Combustion in LOX/H2- and LOX/CH4-Spray Flames [PDF]

, 2005
Propellant injectors are for several reasons of central importance for the performance of rocket combustors. Existing correlations used to guide the design of injectors are mainly based on experimental und theoretical investigations of non-reacting sprays.
Oschwald, M., Cuoco, F., Yang, B., De Rosa, M.   +3 more
openaire   +1 more source

Development and Improvement of Habitat Suitability Criteria for Instream Habitat Assessments Conducted in Support of Environmental Flows in Florida

River Research and Applications, EarlyView.
ABSTRACT Florida's regulatory framework requires the establishment of minimum flows to protect aquatic ecosystems and water resources from significant harm. One of the primary methods used to evaluate significant harm is assessment of instream habitat, which relies on Habitat Suitability Criteria (HSC) curves that relate flow regimes and habitat ...
Eric J. Nagid, Kym Rouse Holzwart
wiley   +1 more source

Genome-wide identification and characterization of lipoxygenases gene family in Luffa aegyptiaca revealed downregulation of LOX genes under heat stress

Scientific Reports
Lipoxygenases (LOXs) are key enzymes in plant lipid metabolism and stress responses, yet their genomic organization and functional dynamics in Luffa aegyptiaca—a species of culinary, medicinal, and ornamental importance—remain unexplored.
Huang Hao, Zhuzheng Xue, Yongping Li, Huifei Ma, Qingfang Wen, Lianyu Lin, Haisheng Zhu   +6 more
doaj   +1 more source