Results 61 to 70 of about 74,325 (301)

Pro-oncogenic action of LOX-1 and its splice variant LOX-1Δ4 in breast cancer phenotypes [PDF]

, 2019
The identification of new predictive biomarkers and therapeutic target for tailored therapy in breast cancer onset and progression is an interesting challenge.
Biancolella, M, Novelli, G, Murdocca, M, Greggi, Chiara, Murdocca, Michela, Amati, F, Sangiuolo, F, Novelli, Giuseppe, Pucci, Sabina, Amati, Francesca, Pucci, S, Morini, E, Polidoro, Chiara, Greggi, C, Biancolella, Michela, Polidoro, C, Orlandi, A, Morini, Elena, Orlandi, Augusto, Sangiuolo, Federica   +19 more
core   +1 more source

Sulfated Cyclocarya Paliurus Polysaccharide Sorchestrates the Gut Microbiome to Mobilize a Host‐Derived 12‐HEPE Against Ulcerative Colitis

Advanced Science, EarlyView.
A sulfated polysaccharide (SCP) from Cyclocarya paliurus alleviates ulcerative colitis by reshaping the gut microbiome. This remodeled microbiota orchestrates the upregulation of the host‐derived lipid 12‐HEPE, which directly inhibits the TLR4/NF‐κB pathway to suppress inflammation.
Xianxiang Chen, Mingyue Shen, Rui Zhang, Zhibing Huang, Hui Niu, Qiang Yu, Yi Chen, Xiangwen Pan, Liyuan Rong, Huiliang Wen, Jun Yang, Jianhua Xie   +11 more
wiley   +1 more source

KRT14 Drives Basal Muscle‐Invasive Bladder Cancer Progression and Lung Metastasis by Directly Binding to and Stabilizing IGF2BP1

Advanced Science, EarlyView.
We identified a Krt14+ Igf2bp1+ bladder cancer population linked to EMT. Mechanistically, KRT14 stabilizes and transports IGF2BP1 to invasive protrusions, initiating a positive feedback loop that drives metastasis and poor outcomes. ABSTRACT Basal‐type muscle‐invasive bladder cancer (BMIBC) is characterized by aggressive metastasis and poor prognosis ...
Shirui Huang, Zhihan Zhou, Qipeng Xie, Zheng Wang, Lijiong He, Yutong Liu, Lijuan Huang, Liuxian Ye, Limeng Hu, Baokun Li, Yang Wang, Xiaohui Hua, Xuelei Liu, Yunping Zhao, Jingxia Li, Jinfei Chen, Guiying Wang, Xian Shen, Wei Chen, Chuanshu Huang   +19 more
wiley   +1 more source

15-Lipoxygenase-1 biosynthesis of 7S,14S-diHDHA implicates 15-lipoxygenase-2 in biosynthesis of resolvin D5[S]

Journal of Lipid Research, 2020
The two oxylipins 7S,14S-dihydroxydocosahexaenoic acid (diHDHA) and 7S,17S-diHDHA [resolvin D5 (RvD5)] have been found in macrophages and infectious inflammatory exudates and are believed to function as specialized pro-resolving mediators (SPMs).
Steven C. Perry, Chakrapani Kalyanaraman, Benjamin E. Tourdot, William S. Conrad, Oluwayomi Akinkugbe, John Cody Freedman, Michael Holinstat, Matthew P. Jacobson, Theodore R. Holman   +8 more
doaj   +1 more source

Low level of stromal lectin‐like oxidized LDL receptor 1 and CD8+ cytotoxic T‐lymphocytes indicate poor prognosis of colorectal cancer

Cancer Reports, 2021
Background Lectin‐like oxidized LDL receptor‐1 (LOX‐1) has been identified as a new marker for functional myeloid‐derived suppressor cells (MDSCs) that exhibit an immunosuppressive phenotype in the tumor microenvironment (TME). However, the role of LOX‐1+
Chika Katayama, Takehiko Yokobori, Naoya Ozawa, Kunihiko Suga, Takuya Shiraishi, Takuhisa Okada, Katsuya Osone, Ryuji Katoh, Toshinaga Suto, Yoko Motegi, Hiroomi Ogawa, Akihiko Sano, Makoto Sakai, Makoto Sohda, Bilguun Erkhem‐Ochir, Navchaa Gombodorj, Ayaka Katayama, Tetsunari Oyama, Ken Shirabe, Hiroyuki Kuwano, Hiroshi Saeki   +20 more
doaj   +1 more source

Targeting Lactate‐Driven Stromal Autophagy via MCT1 Disrupts the Immunosuppressive Niche and Sensitizes Pancreatic Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
Tumor‐derived lactate activates PSCs through MCT1‐mediated Vps34 lactylation and autophagy. These activated PSCs secrete CXCL9/10, upregulating PD‐1 on CD8+ T cells via the CXCR3/STAT3 axis to foster immunosuppression. Disrupting this metabolic crosstalk by targeting MCT1 effectively sensitizes pancreatic cancer to PD‐1 blockade, presenting a promising
Wenfeng Zhuo, Rong Hu, Yuhang Hu, Ping Hu, Shengbo Han, Guozheng Lv, Zhu Zeng, Yong Zhao, Yang Li, Yan Huang, Yingsong Zhao, Hongda Wang, Guangyu Zhao, Eryang Zhao, Gang Zhao   +14 more
wiley   +1 more source

M.tb induces Mcl-1 in a PPARγ- and 15-LOX-dependent manner.

, 2018
A and B) MDMs were transfected with PPARγ (siP) or scrambled control (sc) siRNA then infected with M.tb at MOI 5 for 24 h. C-F) MDMs were treated with the indicated LOX inhibitors (μM) 1 h before, and during, M.tb infection (MOI 5 for 6 h). G and H) MDMs
Ky V. Hoang (5005481), Andrew Hayhurst (254309), Maria J. Montoya (5434622), Larry S. Schlesinger (94895), Michael Li (25311), Eusondia Arnett (199016), Ashlee M. Weaver (5434619), Kiersten C. Woodyard (5434625), Abul K. Azad (2288302)   +8 more
core   +1 more source

Self‐Sustaining Lactate Depletion Nanoplatform Remodels Tumor Microenvironment and Augments Synergistic Photodynamic/Photothermal/Chemodynamic/Starvation Therapy for Eradication of Colon Cancer

Advanced Science, EarlyView.
The HILA nanoplatform integrates HMnO2, LOX, and ICG to orchestrate multimodal therapy (starvation, chemodynamic, photodynamic, and photothermal) for achieving efficient colon cancer eradication. The established HMnO2‐LOX catalytic cycle continuously consumes lactate, acidifys microenvironment, relieves hypoxia, and generats reactive oxygen species ...
Yu‐E. Wang, Shibo Zhao, Wenying Wu, Zhiwei Duan, Yuan Li, Xiangyu Zeng, Liang Hong, Yan Chen, Ling Tao, Kewu Zeng, Chaoda Xiao, Xiangchun Shen   +11 more
wiley   +1 more source

LOX-1 boosts immunity

Oncotarget, 2015
Lectin-like oxidized low-density lipoprotein (LDL) receptor-1 (LOX-1) is a class E scavenger receptor that is encoded by the OLR1 gene on human chromosome 12. LOX-1 is expressed as a type II transmembrane protein containing four domains: an extracellular C-terminal lectin domain, a connecting neck domain, a single transcellular domain and a short N ...
SangKon, Oh, HyeMee, Joo
openaire   +2 more sources

The docking scores and relative binding energies of selective 15-LOX-2, 12-LOX and 15-LOX-1 inhibitors docked to the 15-LOX-2 crystal structure.

, 2014
The docking scores and relative binding energies of selective 15-LOX-2, 12-LOX and 15-LOX-1 inhibitors docked to the 15-LOX-2 crystal structure.
Lena Schultz (238352), David J. Maloney (126223), Matthew P. Jacobson (174588), Ajit Jadhav (85100), Theodore R. Holman (426172), Chakrapani Kalyanaraman (612848), Anton Simeonov (85099), J. Brian Jameson II (612846), Auric Kantz (612847)   +8 more
core   +1 more source