Results 51 to 60 of about 74,325 (301)
Advanced Materials, EarlyView.Oxygen‐releasing hydrogels are widely used to support cell survival in 3D cultures and to promote wound healing. However, incorporating catalase to convert H2O2 into O2 often generates additional oxygen bubbles, leading to material instability which rarely addressed.
Sukulya Bunuasunthon +3 more
wiley +1 more source
Advanced Science, EarlyView.ABSTRACT Diabetes mellitus‐induced erectile dysfunction (DMED) is a highly prevalent complication among diabetic patients; however, its underlying pathogenic mechanisms remain incompletely understood. Metabolic disorder is a hallmark of diabetes, yet its precise contribution to DMED progression is not well defined.
Wanyang Guo +14 more
wiley +1 more source
Advanced Science, EarlyView.Multidimensional laser‐induced graphene (LIG) spanning from 0D to 3D architectures is comprehensively reviewed for multifunctional biomedical platforms, including biosensing, theranostics, and bioactive interface applications, which highlights its potentials for point‐of‐care diagnostics, wearable health monitoring, smart drug delivery, and tissue ...
Li Zhang +3 more
wiley +1 more source
Light‐Controlled Modulation of 15‐Lipoxygenase‐1 Regulates Intestinal Inflammatory Signaling
Angewandte Chemie, EarlyView.The developed target‐guided strategy enables the rational design of diazo‐based photoswitchable inhibitors of 15‐lipoxygenase‐1. Distinct molecular architectures program opposite light‐dependent activity, allowing on‐demand control of enzyme inhibition.
Anastasia Louka +10 more
wiley +2 more sources
Lectin-like oxidized low-density lipoprotein receptor 1 attenuates pneumonia-induced lung injury
JCI Insight, 2022 Identifying host factors that contribute to pneumonia incidence and severity are of utmost importance to guiding the development of more effective therapies.
Filiz T. Korkmaz +16 more
doaj +1 more source
Advanced Science, EarlyView.This study reveals a citrate–ACLY–H3K27ac metabolic–epigenetic axis driving inflammatory gene activation and kidney fibrosis, highlighting ACLY inhibition as a potential therapeutic strategy for chronic kidney disease (CKD). ABSTRACT The mechanisms by which metabolic stress drives epigenetic dysregulation and fibrosis in chronic kidney disease (CKD ...
Chunxiu Du +15 more
wiley +1 more source
O-prenylated 3-carboxycoumarins as a novel class of 15-LOX-1 inhibitors.
, 2017 Allyloxy, Isopentenyloxy, geranyloxy and farnesyloxy derivatives of 3-carboxycoumarin, at position 5, 6, 7, and 8, were synthesized and their inhibitory potency against human 15-lipoxygenase-1 (human 15-LOX-1) were determined.
Atena Jabbari +9 more
core +1 more source
Numerical simulation of a 3D unsteady two-phase flow in the filling cavity in oxygen of a cryogenic rocket-engine [PDF]
, 2012 The feeding of the LOX dome of a cryogenic rocket-engine is a decisive stage of the transient engine ignition. However flight conditions are difficult to reproduce by experimental ground tests. The work reported here is part of an ongoing research effort
Renaud Ansart +11 more
core +1 more source
Advanced Science, EarlyView.Single‐cell and spatial profiling of 110 human thoracic aortic samples reveals a stromal–immune circuit driving aortic dissection. An elastin‐rich fibroblast subset is depleted with age and markedly reduced in disease, weakening aortic wall integrity.
Jing Tao +25 more
wiley +1 more source
Biomarker Research, 2020 Background Lysyl oxidase (LOX) has been described as necessary for premetastatic niche formation in epithelium-derived malignancies and its expression level therefore correlates with risk of metastatic disease and overall survival.
Desiree Kunadt +11 more
doaj +1 more source