Results 31 to 40 of about 74,325 (301)
PatologìâIn modern medical science great attention is paid to the clarification of the molecular mechanisms, which are the basis of adaptation to environmental factors of unusual origin and/or extraordinary strength.
T. V. Ivanenko +2 more
doaj +1 more source
Assessing Drug Interaction and Pharmacokinetics of Loxoprofen in Mice Treated with CYP3A Modulators
Pharmaceutics, 2019 Loxoprofen (LOX) is a non-selective cyclooxygenase inhibitor that is widely used for the treatment of pain and inflammation caused by chronic and transitory conditions.
Sanjita Paudel +9 more
doaj +1 more source
, 2023 We recently introduced the Cre/Lox technology in our laboratory for both transient (mRNA injections) and stable/transgenic experiments. We experienced significant issues such as silencing, mosaicism, and partial recombination using both approaches ...
Haitao Wang +9 more
core +1 more source
Hepatology, EarlyView., 2022 Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog +12 more
wiley +1 more source
Drug Target Insights, 2008 The metabolism of arachidonic acid by either the cyclooxygenase (COX) or lipoxygenase (LOX) pathway generates eicosanoids, which have been implicated in the pathogenesis of a variety of human diseases, including cancer.
Masahide Matsuyama, Rikio Yoshimura
doaj +4 more sources
Molecules, 2018 5-LOX inhibition is among the desired characteristics of anti-inflammatory drugs, while 15-LOX has also been considered as a drug target. Similarity in inhibition behavior between soybean LOX-1 and human 5-LOX has been observed and soybean LOX (sLOX ...
Evangelia Tsolaki +4 more
doaj +1 more source
, 2022 This study has generated proof that plasma-derived exosomes confer PH by delivering LOX-1 into PASMCs. Hence, exosomal LOX-1 represents a novel exploitable target for PH prevention and treatment.
Ning Huang (12223166)
core +1 more source
Characterization of Rosa26-CAG-lox-stop-lox-extracellular-Ruby2-sm-ollas mice.
, 2018 (a) Schematic representation of the synthetic construct used for cell surface expression of the ollas antigen: the mouse Tas1R3 signal peptide was attached to a non-fluorescent mRuby-ollas spaghetti monster that was fused to the CD4 transmembrane domain.
Nicholas J. P. Ryba (148103) +4 more
core +1 more source
Involvement of PLA2, COX and LOX in Rhinella arenarum oocyte maturation [PDF]
, 2013 In Rhinella arenarum, progesterone is the physiological nuclear maturation inducer that interacts with oocyte surface and starts a cascade of events leading to germinal vesicle breakdown (GVBD).
Bühler, Marta Ines +2 more
core +1 more source
Mechanistic insight into lysyl oxidase in vascular remodeling and angiogenesis
Genes and Diseases, 2023 Vascular remodeling and angiogenesis are two key processes in the maintenance of vascular homeostasis and involved in a wide array of vascular pathologies.
Zhao-Jun Wang +4 more
doaj +1 more source