Results 21 to 30 of about 74,325 (301)

Legume lipoxygenase: Strategies for application in food industry

Legume Science, 2020
Lipoxygenase (LOX) is a widely distributed enzyme in plant and animal cells. It catalyzes the oxidation of polyunsaturated fatty acid into fatty acid hydroperoxides.
Yuan Shi, Ronit Mandal, Anika Singh, Anubhav Pratap Singh   +3 more
doaj   +1 more source

Synopsis: Special Issue on “Disruption of signaling homeostasis induced crosstalk in the carcinogenesis paradigm Epistemology of the origin of cancer”

4 open, 2019
It is increasingly evident that carcinogenesis, in the vast majority of cancers, cannot be explained simply through an accumulation of somatic mutations, or epigenetics, the stem cell theory, or the Warburg effect.
Brücher Björn L.D.M., Jamall Ijaz S.
doaj   +1 more source

Modulation of Cox-1, 5-, 12- and 15-Lox by popular herbal remedies used in southern Italy against psoriasis and other skin diseases. [PDF]

, 2015
Acanthus mollis (Acanthaceae), Achillea ligustica, Artemisia arborescens and Inula viscosa (Asteraceae) are used in Southern Italy against psoriasis and other skin diseases that occur with an imbalanced production of eicosanoids.
Ríos, José Luis, Bader, A, Guillermo R. Schinella, Martini, F, Rios, JL, Prieto, JM, Bader, Ammar, Schinella, GR, Francesca Martini, Ammar Bader, Jose L. Rios, Martini, Francesca, Prieto, José M., Schinella, Guillermo Raúl, Jose M. Prieto   +14 more
core   +1 more source

Allosteric Activation of 15‐Lipoxygenase‐1 by Boswellic Acid Induces the Lipid Mediator Class Switch to Promote Resolution of Inflammation

Advanced Science, 2023
Specialized pro‐resolving mediators (SPM), primarily produced in innate immune cells, exert crucial bioactions for resolving inflammation. Among various lipoxygenases (LOX), 15‐LOX‐1 is key for SPM biosynthesis, but cellular activation principles of 15 ...
Friedemann Börner, Simona Pace, Paul M. Jordan, Jana Gerstmeier, Mario Gomez, Antonietta Rossi, Nathaniel C. Gilbert, Marcia E. Newcomer, Oliver Werz   +8 more
doaj   +1 more source

LOX-1: A potential driver of cardiovascular risk in SLE patients

, 2020
Traditional cardiovascular disease (CVD) risk factors, such as hypertension, dyslipidemia and diabetes do not explain the increased CVD burden in systemic lupus erythematosus (SLE).
Jingya Wang (3409949), Ruchi Gupta (205155), Michael A Davis, Saifur Rahman (327290), Joseph Grimsby (1971160), Miguel Sanjuan (6508508), Sotirios Karathanasis (8587200), Gary P. Sims (8587203), Emily L. Ongstad (8587182), Richard Siegel (3412286), Ling-Ling An (8587188), Ling-Ling An, Roland Kolbeck, Jingya Wang, Zerai Manna, Michael A. Davis (8587197), Mehdi Belkhodja, Saifur Rahman, Ranjitha Gaddipati (8587179), Zerai Manna (8587194), Sotirios Karathanasis, Nicholas Bhagroo (8587185), Emily L Ongstad, Roland Kolbeck (193600), Mehdi Belkhodja (8587191), Divya Sagar, Richard Siegel, Joseph Grimsby, Miguel Sanjuan, Gary P Sims, Nicholas Bhagroo, Ranjitha Gaddipati, Ruchi Gupta, Divya Sagar (8587176), Sarfaraz Hasni (529305), Sarfaraz Hasni   +35 more
core   +1 more source

Efeito do inibidor de protease Kunitz sobre níveis de lipoxigenases em sementes de soja Effect of protease inhibitor on the levels of lipoxygenase in soybean seeds

Ciência e Agrotecnologia, 2008
As lipoxigenases (LOX) são responsáveis pelo "beany flavor", sabor característico da soja [Glycine max. (L.) Merrill], que é o maior obstáculo ao consumo da soja nos países ocidentais. O inibidor de tripsina Kunitz (KTI) é responsável por 80% da inibição
Josie Gomes de Almeida Barros, Rita Maria Alves de Moraes, Newton Deniz Piovesan, Everaldo Gonçalves de Barros, Maurilio Alves Moreira   +4 more
doaj   +1 more source

Comparative analysis of right element mutant lox sites on recombination efficiency in embryonic stem cells

BMC Biotechnology, 2010
Background Cre-mediated site-specific integrative recombination in mouse embryonic stem (ES) cells is a useful tool for genome engineering, allowing precise and repeated site-specific integration. To promote the integrative reaction, a left element/right
Araki Masatake, Okada Yuka, Araki Kimi, Yamamura Ken-ichi   +3 more
doaj   +1 more source

Lysyl oxidase inhibits BMP9-induced osteoblastic differentiation through reducing Wnt/β-catenin via HIF-1a repression in 3T3-L1 cells

Journal of Orthopaedic Surgery and Research, 2023
Background Bone morphogenetic protein 9 (BMP9) is a promising growth factor in bone tissue engineering, while the detailed molecular mechanism underlying BMP9-oriented osteogenesis remains unclear.
Jie Zhang, FangLin Ye, AiHua Ye, BaiCheng He   +3 more
doaj   +1 more source

Characterization of Rosa26-CAG-lox-stop-lox-TVA mice.

, 2018
(a) Strategy and (b, c) results of testing heterozygous Rosa26-CAG-lox-Stop-lox-TVA mice for Cre-dependent expression of TVA. (b, c) Confocal images (combined red and green channels) of sections through the region of the brain injected with (b) AAV-hSyn ...
Nicholas J. P. Ryba (148103), Lauren S. Bonilla (4477195), James M. Pickel (4892188), Youmei Wu (4477198), María José Luna (3597602)   +4 more
core   +1 more source

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source