Results 41 to 50 of about 8,654 (267)

Revenue Sharing Contracts in Coalition Loyalty Reward Supply Chain Planning: A Stochastic Programming Approach [PDF]

open access: yesInternational Journal of Industrial Engineering and Production Research, 2023
A coalition loyalty program (CLP) is a business strategy adopted by companies to increase and retain their customers. An operational challenge in this regard is to determine the coordination mechanism with business partners.
Shahla Zandi   +2 more
doaj  

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Self-Produced K-Pop Web Entertainment Program Production Components and Their Effect on Global Audience’s Program Satisfaction and Artist Loyalty—Focusing on “Going Seventeen”

open access: yesSAGE Open, 2023
This study identified production components unique to self-produced web entertainment programs, with a key focus on the program “Going Seventeen.” The researchers identified and used production components as independent variables categorized into human ...
Sofija Limic, Seong-Joon Limb
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

DEVELOPING THE COMPETITIVE ADVANTAGES OF CURING-PREVENTION ESTABLISHMENTS BASING ON THE LOYALTY PROGRAM

open access: yesRussian Journal of Economics and Law, 2013
Objective: to reveal the groups of customer loyalty to the most famous medical establishments and to elaborate the program of internal and external customers’ loyalty of a curing-prevention establishment.
A. L. Faizkhanova
doaj  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

open access: yesMolecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris   +10 more
wiley   +1 more source

CASHBACK: FEATURES OF THE MARKETING ACTIVITIES OF THE BANKING SPHERE

open access: yesВестник Северо-Кавказского федерального университета, 2022
Marketing is a complex mechanism that involves a fairly large number ofpeople. It includes features such as buying, selling, investing, risk accounting, standardization, and more. Support for each function is very important for all parties to trade.
E. Butenko, I. Chernikov
doaj  

The Effectiveness of Loyalty Rewards to Promote the Use of an Internet-Based Heart Health Program

open access: yesJournal of Medical Internet Research, 2014
BackgroundInternet-based health programs have been shown to be effective in reducing risk for cardiovascular disease. However, their rates of enrollment and engagement remain low.
Liu, Sam   +4 more
doaj   +1 more source

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