Results 51 to 60 of about 309,429 (287)
Randomized, double‐blind, phase 1a single‐ascending dose and food effect studies assessing safety and pharmacokinetics of EC5026 in healthy volunteers
Clinical and Translational ScienceChronic pain represents a significant unmet medical need, affecting one‐fifth of the U.S. population. EC5026 is a small molecule inhibitor of the enzyme soluble epoxide hydrolase (sEH) which is being developed as a novel non‐opioid, non‐NSAID analgesic ...William K. Schmidt, Irene Cortés‐Puch, Cindy B. McReynolds, Glenn E. Croston, Sung Hee Hwang, Jun Yang, Theresa L. Pedersen, Karen M. Wagner, Theresa T. Pham, Thomas Hunt, Bruce D. Hammock +10 moredoaj +1 more sourceStability properties of stochastic maximal Lp-regularity
, 2019 In this paper we consider Lp-regularity estimates for solutions to stochastic evolution equations, which is called stochastic maximal Lp-regularity. Our aim is to find a theory which is analogously to Dore’s theory for deterministic evolution equations ...Veraar, M.C., Agresti A., Agresti, A., Veraar M., Agresti, A. (author), Veraar, M.C. (author) +5 morecore +1 more sourceEDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot +36 morewiley +1 more sourceDifferential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales +11 morewiley +1 more sourceThe quotient shapes of lp and Lp spaces
Rad Hrvatske akademije znanosti i umjetnosti. Matematičke znanosti, 2018 All lp spaces (over the same field), p ≠ ∞, have the finite quotient shape type of the Hilbert space l2. It is also the finite quotient shape type of all the subspaces lp(p'), p < p' ≤ ∞, as well as of all their direct sum subspaces F0N(p'), 1 ≤ p' ≤ ∞. Furthermore, their countable and finite quotient shape types coincide.openaire +2 more sourcesHeterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig +10 morewiley +1 more sourceSkin biopsies and melanocyte cultures for LP/LP and lp/lp samples.
, 2013 Coat color phenotypes of (A) LP/LP horse and (B) lp/lp . Close-up views of the biopsied skin from LP/LP horse (C) unpigmented samples and (E) pigmented spot.Martina Engensteiner (475385), Monika Reissmann (234862), Daniel Foerster (475381), Sulochana Devi (475378), Sheila Archer (475379), Bruce Grahn (475391), Michael J. Mienaltowski (475387), Johanna L. A. Paijmans (475389), Heather Holl (475377), Vijayasaradhi Setaluri (19642), Rebecca R. Bellone (316199), Lynne Sandmeyer (475380), Nityanand Maddodi (19640), Bianca Haase (81664), Ralf Bortfeldt (475382), George Forsyth (475386), Arne Ludwig (53733), Sim Lin Lim (475383), Gloria Gonzalez-Fortes (475390), Janelle Nelson (475384), Michael Hofreiter (2821), Melanie Pruvost (234855), David L. Adelson (110514), Tosso Leeb (81674), Samantha A. Brooks (171540), Padmanabhan Mahadevan (475388) +25 morecore +1 more sourceApoCIII-Lp(a) complexes in conjunction with Lp(a)-OxPL predict rapid progression of aortic stenosis
, 2020 Objective This study assessed whether apolipoprotein CIII-lipoprotein(a) complexes (ApoCIII-Lp(a)) associate with progression of calcific aortic valve stenosis (AS).Ulrich F W Franke, Mathieu, Patrick, Bossé, Yohan, Romain Capoulade, Torzewski, Michael, Kwan-Leung Chan, Amber Sanchez, Benoit Arsenault, Burnap, Sean A., Dumesnil, Jean G., Arsenault, Benoit, Sean A. Burnap, Patrick Mathieu, Xiaohong Yang, Jean-Pierre Després, Sanchez, Amber, Michael Torzewski, James Tam, Calvin Yeang, Capoulade, Romain, Witztum, Joseph L., Teo, Koon K., Pibarot, Philippe, Jean G Dumesnil, Jens Schmid, Yohan Bossé, Joseph L Witztum, Sotirios Tsimikas, Tam, James, Després, Jean Pierre, Chan, Kwan Leung, Koon K Teo, Gobel, Nora, Schmid, Jens, Philippe Pibarot, Mayr, Manuel; id_orcid, Franke, Ulrich F.W., Tsimikas, Sotirios, Yeang, Calvin, Nora Gobel, Yang, Xiaohong, Manuel Mayr +41 morecore +1 more sourceInterpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo +7 morewiley +1 more sourceLP/LP and lp/lp equine melanocyte culture data.
, 2013 (A) Ultrastructure of melanocytes from human and horse epidermis at passages 3, 5, and 2 (humans, lp/lp and LP/LP respectively) were plated on glass coverslips and processed for transmission electron microscopy.Martina Engensteiner (475385), Monika Reissmann (234862), Daniel Foerster (475381), Sulochana Devi (475378), Sheila Archer (475379), Bruce Grahn (475391), Michael J. Mienaltowski (475387), Johanna L. A. Paijmans (475389), Heather Holl (475377), Vijayasaradhi Setaluri (19642), Rebecca R. Bellone (316199), Lynne Sandmeyer (475380), Nityanand Maddodi (19640), Bianca Haase (81664), Ralf Bortfeldt (475382), George Forsyth (475386), Arne Ludwig (53733), Sim Lin Lim (475383), Gloria Gonzalez-Fortes (475390), Janelle Nelson (475384), Michael Hofreiter (2821), Melanie Pruvost (234855), David L. Adelson (110514), Tosso Leeb (81674), Samantha A. Brooks (171540), Padmanabhan Mahadevan (475388) +25 morecore +1 more source
