Results 11 to 20 of about 113,253 (324)

LPP3 mediates self-generation of chemotactic LPA gradients by melanoma cells [PDF]

Journal of Cell Science, 2017
Melanoma cells steer out of tumours using self-generated lysophosphatidic acid (LPA) gradients. The cells break down LPA, which is present at high levels around the tumours, creating a dynamic gradient that is low in the tumour and high outside.
Insall, Robert H., Kamphorst, Jurre J., Koh, Yvette W.H., Mackay, Gillian M., Morrice, Nick, Muinonen-Martin, Andrew J., Nielson, Matthew, Susanto, Olivia, Thomason, Peter A., Tumanov, Sergey, Tweedy, Luke   +10 more
core   +2 more sources

Melanoma cells break down LPA to establish local gradients that drive chemotactic dispersal. [PDF]

PLoS Biology, 2014
The high mortality of melanoma is caused by rapid spread of cancer cells, which occurs unusually early in tumour evolution. Unlike most solid tumours, thickness rather than cytological markers or differentiation is the best guide to metastatic potential.
A Boucharaba, AD Mackenzie Ross, AJ Houben, AJ Muinonen-Martin, AJ Snider, AL Parrill, AM Algra, Andre Levchenko, Andrew J. Muinonen-Martin, C Carmona-Fontaine, C Scherber, C Zhao, CK Griffith, CM Balch, Colin Lindsay, D Dankort, D Zicha, D Zicha, David A. Knecht, Dorothy C. Bennett, Douwe M. Veltman, E Dona, E Lee, E Sierko, E Theveneau, Elizabeth Smethurst, ET Roussos, F Wach, G Tigyi, G Valentin, G Venkiteswaran, Gabriela Kalna, GL Garcia, J Condeelis, J Condeelis, J Murata, J Sleeman, J Wyckoff, JD Pedelacq, JM Haugh, JP Sleeman, JT Price, K Bandoh, K Jalink, Laura M. Machesky, M Abercrombie, M Gotoh, M Herlyn, M Jongsma, M Zaki, Michael J. O. Wakelam, MJ Payette, N Aaltonen, Olivia Susanto, Owen J. Sansom, P Berens, P Timpson, PN Devreotes, Qifeng Zhang, RA Sturm, Robert H. Insall, Robert Herd, Robert Jones, RR Langley, S Kuriyama, S Toetsch, S Toyozawa, SA Jordan, SH Zigmond, SH Zigmond, SK Hughes-Alford, W Wang, William J. Faller   +72 more
core   +4 more sources

Lipoprotein(a) beyond the kringle IV repeat polymorphism: The complexity of genetic variation in the LPA gene

Atherosclerosis, 2022
High lipoprotein(a) [Lp(a)] concentrations are one of the most important genetically determined risk factors for cardiovascular disease. Lp(a) concentrations are an enigmatic trait largely controlled by one single gene (LPA) that contains a complex ...
S. Coassin, F. Kronenberg
semanticscholar   +1 more source

Autotaxin facilitates selective LPA receptor signaling

bioRxiv, 2022
Autotaxin (ATX; ENPP2) produces the lipid mediator lysophosphatidic acid (LPA) that signals through disparate EDG (LPA1-3) and P2Y (LPA4-6) G protein-coupled receptors.
Fernando Salgado-Polo, Razvan Borza, F. Marsais, C. Jagerschmidt, L. Waeckel, W. Moolenaar, Paul Ford, B. Heckmann, A. Perrakis   +8 more
semanticscholar   +1 more source

Resveratrol Contrasts LPA-Induced Ovarian Cancer Cell Migration and Platinum Resistance by Rescuing Hedgehog-Mediated Autophagy

Cells, 2021
Background: Ovarian cancer progression and invasiveness are promoted by a range of soluble factors released by cancer cells and stromal cells within the tumor microenvironment.
Alessandra Ferraresi, Andrea Esposito, Carlo Girone, Letizia Vallino, A. Salwa, Ian Ghezzi, Suyanee Thongchot, Chiara Vidoni, D. Dhanasekaran, C. Isidoro   +9 more
semanticscholar   +1 more source

Lysophosphatidic Acid Signaling in Cancer Cells: What Makes LPA So Special?

Cells, 2021
Lysophosphatidic acid (LPA) refers to a family of simple phospholipids that act as ligands for G protein-coupled receptors. While LPA exerts effects throughout the body in normal physiological circumstances, its pathological role in cancer is of great ...
Pravita Balijepalli, C. C. Sitton, K. Meier   +2 more
semanticscholar   +1 more source

LPA signaling acts as a cell-extrinsic mechanism to initiate cilia disassembly and promote neurogenesis

Nature Communications, 2021
Dynamic assembly and disassembly of primary cilia controls embryonic development and tissue homeostasis. Dysregulation of ciliogenesis causes human developmental diseases termed ciliopathies. Cell-intrinsic regulatory mechanisms of cilia disassembly have
Huaibin Hu, Zeng-Qing Song, Guang-Ping Song, Sen Li, Hai-Qing Tu, Min Wu, Yu-Cheng Zhang, Jin-Feng Yuan, Tingting Li, Pei-Yao Li, Yu-Ling Xu, Xiao-Lin Shen, Qiu-Ying Han, Ai-ling Li, Tao Zhou, J. Chun, Xue-Min Zhang, Hui-Yan Li   +17 more
semanticscholar   +1 more source

LPA-MNI: An Improved Label Propagation Algorithm Based on Modularity and Node Importance for Community Detection

Entropy, 2021
Community detection is of great significance in understanding the structure of the network. Label propagation algorithm (LPA) is a classical and effective method, but it has the problems of randomness and instability.
Huan Li, Ruisheng Zhang, Zhili Zhao, Xin Liu   +3 more
semanticscholar   +1 more source

Evaluation of serum ATX and LPA as potential diagnostic biomarkers in patients with pancreatic cancer

BMC Gastroenterology, 2021
Background Pancreatic cancer (PC) is a devastating disease that has a poor prognosis and a total 5-year survival rate of around 5%. The poor prognosis of PC is due in part to a lack of suitable biomarkers that can allow early diagnosis.
Jiang Chen, Hongyu Li, Wenda Xu, Xiaozhong Guo   +3 more
semanticscholar   +1 more source

Clinical Utility of Lipoprotein(a) and LPA Genetic Risk Score in Risk Prediction of Incident Atherosclerotic Cardiovascular Disease

JAMA cardiology, 2020
Key Points Question Does measurement of lipoprotein(a) and/or LPA genetic risk score (GRS) have clinical utility in risk prediction of incident atherosclerotic cardiovascular disease (ASCVD)?
M. Trinder, M. Uddin, Phoebe Finneran, Krishna G. Aragam, P. Natarajan   +4 more
semanticscholar   +1 more source