Results 51 to 60 of about 35,088 (264)

Lysophosphatidic Acid Induced Apoptosis, DNA Damage, and Oxidative Stress in Spinal Cord Neurons by Upregulating LPA4/LPA6 Receptors

Mediators of Inflammation, 2022
Lysophosphatidic acid (LPA) has disruptive effects on lumbar spinal stenosis (LSS). Recently, LPA has been reported to be involved in spinal cord neuronal injury and toxicity, promoting the pathogenesis of LSS. However, the exact effects of LPA on spinal
Yifan Yang, Jing Xu, Qingxin Su, Yiran Wu, Qizheng Li, Zongren Ma, Tao Ding   +6 more
doaj   +1 more source

Lysophosphatidic Acid Receptor 5 Contributes to Imiquimod-Induced Psoriasis-Like Lesions through NLRP3 Inflammasome Activation in Macrophages

Cells, 2020
The pathogenesis of psoriasis, an immune-mediated chronic skin barrier disease, is not fully understood yet. Here, we identified lysophosphatidic acid (LPA) receptor 5 (LPA5)-mediated signaling as a novel pathogenic factor in psoriasis using an imiquimod-
Bhakta Prasad Gaire, Chi-Ho Lee, Wondong Kim, Arjun Sapkota, Do Yup Lee, Ji Woong Choi   +5 more
doaj   +1 more source

Connecting the dots: A narrative review of the relationship between heart failure and cognitive impairment

ESC Heart Failure, Volume 12, Issue 2, Page 1119-1131, April 2025.
Abstract Large clinical data underscore that heart failure is independently associated to an increased risk of negative cognitive outcome and dementia. Emerging evidence suggests that cerebral hypoperfusion, stemming from reduced cardiac output and vascular pathology, may contribute to the largely overlapping vascular dementia and Alzheimer's disease ...
Mauro Massussi, Maria Giulia Bellicini, Marianna Adamo, Andrea Pilotto, Marco Metra, Alessandro Padovani, Riccardo Proietti   +6 more
wiley   +1 more source

Lysophosphatidic acid induces integrin activation in vascular smooth muscle and alters arteriolar myogenic vasoconstriction

Frontiers in Physiology, 2014
In vascular smooth muscle cells (VSMC) increased integrin adhesion to extracellular matrix (ECM) proteins, as well as the production of reactive oxygen species (ROS) are strongly stimulated by lysophosphatidic acid (LPA). We hypothesized that LPA-induced
Marius C. Staiculescu, Francisco I. Ramirez-Perez, Francisco I. Ramirez-Perez, Jorge A. Castorena-Gonzalez, Jorge A. Castorena-Gonzalez, Zhongkui eHong, Zhe eSun, Gerald A. Meininger, Gerald A. Meininger, Gerald A. Meininger, Luis A. Martinez-Lemus, Luis A. Martinez-Lemus, Luis A. Martinez-Lemus   +12 more
doaj   +1 more source

Identifying Affective Patterns in Patients With Eating Disorders: A Latent Profile Analysis

European Eating Disorders Review, EarlyView.
ABSTRACT Background Emotional difficulties are common among individuals with Eating Disorders (EDs). Following Panksepp's theoretical model, which conceptualises primary emotional systems as the evolutionary foundation of personality, this study aimed to identify distinct profiles of primary emotional systems within a clinical eating disorder (ED ...
Rachele Fasolato, Chiara Bonetto, Rosa Bruna Dall’Agnola, Emily Boifava, Federica Bonora, Mariasole Castellazzi, Silvia Castelli, Doriana Cristofalo, Silvia Danese, Monica Ferlin, Stuart B. Murray, Martina Puglisi, Silvia Rigon, Antonio Elia Rizzo, Benedetta Signoretto, Corrado Barbui   +15 more
wiley   +1 more source

A retrospective record-based study to evaluate the profile of TB patients diagnosed and registered at DOTS center at the tertiary care center and to study the gaps in the implementation of the latest guidelines toward TB elimination

The Journal of Association of Chest Physicians
Context: Tuberculosis (TB) has infected mankind since time immemorial. India has been a breeding ground for this disease due to high population density and lack of awareness and education in the population.
Ruchi Arora Sachdeva, Sahil Singh, MK Sen   +2 more
doaj   +1 more source

Predicting and Preventing Turnover in Industry 4.0: Understanding the Impact of Artificial Intelligence Adoption on Employee Turnover

Human Resource Development Quarterly, EarlyView.
ABSTRACT With the increasing adoption of Artificial Intelligence (AI) in the workplace, employees' career paths have become more diverse and less predictable in the era of Industry 4.0. As technological transformations accelerate, employee turnover patterns are also changing, as reflected in the growing prevalence of occupational transitions and large ...
Young‐Kook Moon, Tanya Mitropoulos
wiley   +1 more source

Lysophosphatidic Acid Is Associated With Cardiac Dysfunction and Hypertrophy by Suppressing Autophagy via the LPA3/AKT/mTOR Pathway

Frontiers in Physiology, 2018
Background: Lysophosphatidic acid (LPA), as a phospholipid signal molecule, participates in the regulation of various biological functions. Our previous study demonstrated that LPA induces cardiomyocyte hypertrophy in vitro; however, the functional role ...
Jinjing Yang, Jinjing Yang, Jinjing Yang, Jiyao Xu, Jiyao Xu, Xuebin Han, Xuebin Han, Hao Wang, Yuean Zhang, Yuean Zhang, Jin Dong, Jin Dong, Yongzhi Deng, Yongzhi Deng, Jingping Wang, Jingping Wang   +15 more
doaj   +1 more source

Revisiting Maternal and Paternal Parenting Styles: Differentiating Latent Profiles and Associations With Psychosocial Outcomes of Chinese Adolescents in a National Sample of Parent‐Child Dyads

Journal of Adolescence, EarlyView.
ABSTRACT Introduction Parent‐child interactions constitute a critical developmental context for the psychosocial adjustment of adolescents. This study aimed to differentiate parenting styles and examine their domain‐specific effects on later adolescent outcomes, using a culturally sensitive, person‐centered approach.
Yuhang Cheng, Randolph C. H. Chan
wiley   +1 more source

Structural and functional differences of subspecies of apoA-I-containing lipoprotein in patients with plasma cholesteryl ester transfer protein deficiency.

Journal of Lipid Research, 1995
ApoA-I-containing lipoproteins exist in plasma in two main forms: one contains only apoA-I (LpA-I) while the other contains both apoA-I and apoA-II (LpA-I/A-II).
T Ohta, R Nakamura, K Takata, Y Saito, S Yamashita, S Horiuchi, I Matsuda   +6 more
doaj   +1 more source