Results 51 to 60 of about 98,340 (281)
Advanced Science, EarlyView.Cer24:1 levels are reduced in neutrophilic asthma and inversely correlate with disease severity and airway neutrophilia. Restoring Cer24:1 suppresses pathogenic Th17 differentiation by engaging EP2 on CD4+ T cells, thereby dampening the JAK2–STAT3–RORγt axis and reducing IL‐17 production.
Huan Liu +11 more
wiley +1 more source
Medycyna PracyBackground This study aimed to identify distinct employee and organizational profiles influencing workplace safety behaviors (compliance and participation) using latent profile analysis (LPA), focusing on psychological need satisfaction, work performance,
Łukasz Kapica +2 more
doaj +1 more source
A density property for fractional weighted Sobolev spaces [PDF]
, 2015 In this paper we show a density property for fractional weighted Sobolev spaces. That is, we prove that any function in a fractional weighted Sobolev space can be approximated by a smooth function with compact support. The additional difficulty in this
Dipierro, Serena, Valdinoci, Enrico
core +4 more sources
Integrating Spatial Proteogenomics in Cancer Research
Advanced Science, EarlyView.Xx xx. ABSTRACT Background: Spatial proteogenomics marks a paradigm shift in oncology by integrating molecular analysis with spatial information from both spatial proteomics and other data modalities (e.g., spatial transcriptomics), thereby unveiling tumor heterogeneity and dynamic changes in the microenvironment.
Yida Wang +13 more
wiley +1 more source
Enhancing adult hippocampal neurogenesis with lysophosphatidic acid: a proposal for erasing cocaine contextual memory [PDF]
, 2018 Stimulating adult hippocampal neurogenesis (AHN) has been uncovered as a promising approach in the manipulation of retrograde memories. This work aims to study whether increasing AHN with lysophosphatidic acid (LPA, an endogenous lysophospholipid with ...
Castilla Ortega, María Estela +9 more
core
Advanced Science, EarlyView.This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon +21 more
wiley +1 more source
The PDZ protein GIPC regulates trafficking of the LPA1 receptor from APPL signaling endosomes and attenuates the cell's response to LPA. [PDF]
PLoS ONE, 2012 Lysophosphatidic acid (LPA) mediates diverse cellular responses through the activation of at least six LPA receptors--LPA(1-6,) but the interacting proteins and signaling pathways that mediate the specificity of these receptors are largely unknown.
Tal Varsano +4 more
doaj +1 more source
Beam Scraping in the SPS for LHC Injection: Efficiency and Robustness Studies [PDF]
, 2008 The Large Hadron Collider (LHC) at CERN will be the world's most powerful accelerator when it is commissioned in fall 2008. Operation of the LHC will require injection of very high intensity beams. Fast transverse beam scrapers have been installed in the
Letnes, Paul/LPA
core
Fluid Communities: A Competitive, Scalable and Diverse Community Detection Algorithm
, 2017 We introduce a community detection algorithm (Fluid Communities) based on the idea of fluids interacting in an environment, expanding and contracting as a result of that interaction.
Ayguadé, Eduard +7 more
core +1 more source
Neighborhood social environments and mental health among youth and adults in public housing
American Journal of Community Psychology, EarlyView.Abstract Neighborhoods influence health in part through social processes. However, little is known about how multiple neighborhood social processes co‐occur, or about within (vs. between) neighborhood variation in social processes and health. This study asked how residents of a large public housing development describe their neighborhood and used ...
Jane Leer +3 more
wiley +1 more source