Results 1 to 10 of about 18,267 (137)
Lysophosphatidic acid mediates myeloid differentiation within the human bone marrow microenvironment. [PDF]
PLoS ONE, 2013 Lysophosphatidic acid (LPA) is a pleiotropic phospholipid present in the blood and certain tissues at high concentrations; its diverse effects are mediated through differential, tissue specific expression of LPA receptors.
Denis Evseenko +9 more
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Multiple actions of lysophosphatidic acid on fibroblasts revealed by transcriptional profiling [PDF]
BMC Genomics, 2008 Background Lysophosphatidic acid (LPA) is a lipid mediator that acts through specific G protein-coupled receptors to stimulate the proliferation, migration and survival of many cell types.
Moolenaar Wouter H +2 more
doaj +4 more sources
Lysophosphatidic acid promotes endometrial decidualization in recurrent implantation failure patients by regulating LPAR6 [PDF]
Frontiers in Cell and Developmental BiologyBackgroundImpaired decidualization is associated with recurrent implantation failure (RIF) and lysophosphatidic acid (LPA) is known to play an important role in decidua formation.
Shanshan Wang +5 more
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Cells, 2021 Lysophosphatidic acid (LPA) is a bioactive lipid mediator primarily derived from membrane phospholipids. LPA initiates cellular effects upon binding to a family of G protein-coupled receptors, termed LPA receptors (LPAR1 to LPAR6).
Yu-Hsuan Lin +2 more
doaj +1 more source
The PDZ protein GIPC regulates trafficking of the LPA1 receptor from APPL signaling endosomes and attenuates the cell's response to LPA. [PDF]
PLoS ONE, 2012 Lysophosphatidic acid (LPA) mediates diverse cellular responses through the activation of at least six LPA receptors--LPA(1-6,) but the interacting proteins and signaling pathways that mediate the specificity of these receptors are largely unknown.
Tal Varsano +4 more
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Involvement of LPA Receptor 3 in LPA-induced BGC- 803 Cell Migration [PDF]
Mongolian Journal of Biological Sciences, 2013 Lysophosphatidic acid ˄ LPA ˅ is a bioactive phospholipid mediator, which elicits a variety of biological functions mainly through G-protein coupled receptors. Although LPA is shown to stimulate proliferation and motility via LPA receptors, LPAR1
Erdene Oyungerel +4 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Lysophosphatidic acid (LPA), a lipid metabolite, plays a role in both neuropathic and inflammatory pain through LPA1 receptors. P2X3 receptor has also been shown to participate in these pathological processes.
Wen-Long Qiao +12 more
doaj +1 more source
Frontiers in Physiology, 2021 Central micturition control and urine storage involve a multisynaptic neuronal circuit for the efferent control of the urinary bladder. Electrical stimulation of the lateral preoptic area (LPA) at the level of the decussation of the anterior commissure ...
Gustavo B. Lamy +10 more
doaj +1 more source
Identification of heparin-binding EGF-like growth factor (HB-EGF) as a biomarker for lysophosphatidic acid receptor type 1 (LPA1) activation in human breast and prostate cancers. [PDF]
PLoS ONE, 2014 Lysophosphatidic acid (LPA) is a natural bioactive lipid with growth factor-like functions due to activation of a series of six G protein-coupled receptors (LPA₁₋₆).
Marion David +7 more
doaj +1 more source
BMC Neurology, 2022 Lysophosphatidic acid (LPA) is a common glycerol phospholipid and an important extracellular signaling molecule. LPA binds to its receptors and mediates a variety of biological effects, including the pathophysiological process underlying ischemic brain ...
Yaya Wang +7 more
doaj +1 more source