Results 91 to 100 of about 18,337 (203)
Exosomes promote pre-metastatic niche formation in ovarian cancer. [PDF]
, 2019 Ovarian cancer is one of the most common gynecological malignancies. Upon initial diagnosis, the majority of patients present with widespread metastatic growth within the peritoneal cavity. This metastatic growth occurs in stages, with the formation of a
Dean, Dylan C +4 more
core +2 more sources
Interaction of Gα₁₂ with Gα₁₃ and Gα_q signaling pathways [PDF]
, 2002 The G(12) subfamily of heterotrimeric G-proteins consists of two members, G(12) and G(13). Gene-targeting studies have revealed a role for G(13) in blood vessel development. Mice lacking the a subunit of G(13) die around embryonic day 10 as the result of
Gu, Jennifer L. +4 more
core
Autotaxin in Pathophysiology and Pulmonary Fibrosis
Frontiers in Medicine, 2018 Lysophospholipid signaling is emerging as a druggable regulator of pathophysiological responses, and especially fibrosis, exemplified by the relative ongoing clinical trials in idiopathic pulmonary fibrosis (IPF) patients.
Ioanna Ninou +2 more
doaj +1 more source
Docosatetraenoyl LPA is elevated in exhaled breath condensate in idiopathic pulmonary fibrosis [PDF]
, 2014 Background: Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal disease with no effective medical therapies. Recent research has focused on identifying the biological processes essential to the development and progression of fibrosis, and on ...
Berdyshev, Evgeny V +6 more
core +2 more sources
Gintonin influences the morphology and motility of adult brain neurons via LPA receptors. [PDF]
J Ginseng Res, 2021 Kim DG +8 more
europepmc +1 more source
Bronchial Circulation Angiogenesis in the Rat Quantified with SPECT and Micro-CT [PDF]
, 2008 Introduction As pulmonary artery obstruction results in proliferation of the bronchial circulation in a variety of species, we investigated this angiogenic response using single photon emission computed tomography (SPECT) and micro-CT.
Clough, Anne V. +5 more
core +2 more sources
The FASEB Journal, 2009 Both LPA and serum stimulate lung fibroblast proliferation and contraction, important components of wound healing and of the pathologic airway remodeling in fibrotic lung diseases. LPA and its LPA1 receptor have been identified as critical mediators of pulmonary fibrosis.
Bridget A. Leuschen +2 more
openaire +1 more source
Eye and Brain, 2010 Eric Birgbauer, Jerold ChunDepartment of Molecular Biology, Helen L Dorris Institute for Neurological and Psychiatric Disorders, The Scripps Research Institute, La Jolla, CA, USA Abstract: One of the major requirements in the development of the visual ...
Eric Birgbauer, Jerold Chun
doaj
Pathophysiology, 2005 BACKGROUND:: Apolipoprotein(a) (apo(a)), which is part of the atherogenic lipoprotein Lp(a), shares structural homology with plasminogen (plg). Genes coding for plasminogen (PLG) and apo(a) (LPA) are linked and situated 40kb apart in the telomeric region of the long arm of chromosome 6. LPA is naturally expressed only in primates and hedgehogs.
Päivi A, Teivainen-Laedre +4 more
openaire +2 more sources
International Journal of Inflammation, 2011 Lysophosphatidic acid (LPA) is a lipid mediator which binds to G-protein-coupled receptors and regulates various cellular responses, including inflammation of endothelial cells.
Chih-Hsin Lin, JenHer Lu, Hsinyu Lee
doaj +1 more source