Results 41 to 50 of about 18,337 (203)

TRPV1 channels are critical brain inflammation detectors and neuropathic pain biomarkers in mice [PDF]

, 2017
The capsaicin receptor TRPV1 has been widely characterized in the sensory system as a key component of pain and inflammation. A large amount of evidence shows that TRPV1 is also functional in the brain although its role is still debated.
Chiurchiù, Valerio, Giustizieri, Michela, Leuti, Alessandro, Lombardi, Marta, Maccarrone, Mauro, Marinelli, Sara, Marinelli, Silvia, Marrone, Maria Cristina, Mattioli, Marzia, Morabito, Annunziato, Murana, Emanuele, Oddi, Sergio, Piomelli, Daniele, Ragozzino, Davide Antonio, Riganti, Loredana, Totaro, Antonio, Verderio, Claudia   +16 more
core   +3 more sources

LPA₁, LPA₂, LPA₄, and LPA₆ receptor expression during mouse brain development [PDF]

Developmental Dynamics, 2019
AbstractBackgroundLPA is a small bioactive phospholipid that acts as an extracellular signaling molecule and is involved in cellular processes, including cell proliferation, migration, and differentiation. LPA acts by binding and activating at least six known G protein–coupled receptors: LPA1–6.
Olga Suckau, Isabel Gross, Sandra Schrötter, Fan Yang, Jiankai Luo, Andreas Wree, Jerold Chun, David Baska, Jan Baumgart, Kuniyuki Kano, Junken Aoki, Anja U. Bräuer   +11 more
openaire   +3 more sources

2-Carba-lysophosphatidic acid is a novel β-lysophosphatidic acid analogue with high potential for lysophosphatidic acid receptor activation and autotaxin inhibition

Scientific Reports, 2021
Cyclic phosphatidic acid (cPA) is a naturally occurring phospholipid mediator that, along with its chemically stabilized analogue 2-carba-cyclic phosphatidic acid (2ccPA), induces various biological activities in vitro and in vivo.
Keiko Fukasawa, Mari Gotoh, Akiharu Uwamizu, Takatsugu Hirokawa, Masaki Ishikawa, Yoshibumi Shimizu, Shinji Yamamoto, Kensuke Iwasa, Keisuke Yoshikawa, Junken Aoki, Kimiko Murakami-Murofushi   +10 more
doaj   +1 more source

The role of epidermal growth factor-like module containing mucin-like hormone receptor 2 in human cancers. [PDF]

, 2014
G-protein coupled receptors (GPCRs) are among the most diverse and ubiquitous proteins in all of biology. The epidermal growth factor-seven span transmembrane (EGF-TM7) subfamily of adhesion GPCRs is a small subset whose members are mainly expressed on ...
Bloch, Orin, Ivan, Michael E, Kaur, Gurvinder, Oh, Michael C, Oh, Taemin, Parsa, Andrew T, Safaee, Michael, Sayegh, Eli T, Sun, Matthew Z   +8 more
core   +2 more sources

Role of lysophosphatidic acid and its receptors in health and disease: novel therapeutic strategies

Signal Transduction and Targeted Therapy, 2021
Lysophosphatidic acid (LPA) is an abundant bioactive phospholipid, with multiple functions both in development and in pathological conditions. Here, we review the literature about the differential signaling of LPA through its specific receptors, which ...
Luiz Henrique Medeiros Geraldo, Tânia Cristina Leite de Sampaio Spohr, Rackele Ferreira do Amaral, Anna Carolina Carvalho da Fonseca, Celina Garcia, Fabio de Almeida Mendes, Catarina Freitas, Marcos Fabio dosSantos, Flavia Regina Souza Lima   +8 more
doaj   +1 more source

In vitro pharmacological characterization of standard and new lysophosphatidic acid receptor antagonists using dynamic mass redistribution assay

Frontiers in Pharmacology, 2023
Lysophosphatidic acid (LPA) is a bioactive phospholipid that acts as an agonist of six G protein-coupled receptors named LPA receptors (LPA1-6).
C. Ruzza, C. Ruzza, M. Argentieri, F. Ferrari, E. Armani, M. Trevisani, G. Marchini, G. Calo’   +7 more
doaj   +1 more source

Lysophospholipid (LPA) receptors in GtoPdb v.2023.1

IUPHAR/BPS Guide to Pharmacology CITE, 2023
Lysophosphatidic acid (LPA) receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Lysophospholipid Receptors [62, 23, 91, 144]) are activated by the endogenous phospholipid LPA. The first receptor, LPA1, was identified as ventricular zone gene-1 (vzg-1) [46], This discovery represented the beginning of the de-orphanisation of members of ...
Valerie P. Tan, Manisha Ray, Tony Ngo, Yasuyuki Kihara, Jerold Chun   +4 more
openaire   +1 more source

Lysophospholipid Growth Factors and Their G Protein-Coupled Receptors in Immunity, Coronary Artery Disease, and Cancer

The Scientific World Journal, 2002
The physiological lysophospholipids (LPLs), exemplified by lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), are omnific mediators of normal cellular proliferation, survival, and functions.
Edward J. Goetzl, Markus Graeler, Mei-Chuan Huang, Geetha Shankar   +3 more
doaj   +1 more source

Elevated plasma levels of lysophosphatidic acid and aberrant expression of lysophosphatidic acid receptors in adenomyosis

BMC Women's Health, 2017
Background Given the important roles of the receptor-mediated lysophosphatidic acid (LPA) signaling in both reproductive tract function and gynecological cancers, it will be informative to investigate the potential role of LPA in the development of ...
Bicheng Yang, Liqun Wang, Xiaoju Wan, Yunjun Li, Xiaohong Yu, Yunna Qin, Yong Luo, Feng Wang, Ouping Huang   +8 more
doaj   +1 more source

Structural identification of oxidized acyl-phosphatidylcholines that induce platelet activation [PDF]

, 2005
Oxidation of low-density lipoprotein (LDL) generates proinflammatory and prothrombotic mediators that may play a crucial role in cardiovascular and inflammatory diseases.
Berliner JA, Bittman R, Casals-Stenzal J, Esterbauer H, Fernandez-Ortiz A, Frey B, Goetzl EJ, Holvoet P, Itabe H, Kamido H, Kamido H, Kern H, Kinsella BT, Kitagawa S, O'Flaherty JT, O'Flaherty JT, Rasmussen UB, Sevanian A, Subbanagounder G, Tanaka T, Trip MD, Volf I, Watson AD, Weidtmann A   +23 more
core   +1 more source