Results 61 to 70 of about 18,337 (203)
PLoS ONE, 2016 Hepatocellular carcinoma (HCC) commonly develops in patients with liver fibrosis; in these patients, the blood levels of lysophosphatidic acid (LPA) and its generating enzyme autotaxin (ATX) increase with the liver fibrosis stage. We aimed to examine the
Kenichiro Enooku +10 more
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LPA5 is abundantly expressed by human mast cells and important for lysophosphatidic acid induced MIP-1β release. [PDF]
PLoS ONE, 2011 Lysophosphatidic acid (LPA) is a bioactive lipid inducing proliferation, differentiation as well as cytokine release by mast cells through G-protein coupled receptors. Recently GPR92/LPA5 was identified as an LPA receptor highly expressed by cells of the
Anders Lundequist, Joshua A Boyce
doaj +1 more source
Lysophosphatidic Acid Induces Migration of Human Lung‐Resident Mesenchymal Stem Cells Through the β‐Catenin Pathway [PDF]
, 2012 Mesenchymal stem cells (MSCs) have been demonstrated to reside in human adult organs. However, mechanisms of migration of these endogenous MSCs within their tissue of origin are not well understood.
Anliker +33 more
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Cellular Physiology and Biochemistry, 2017 Background/Aims: Obesity is a main risk factor for the development of hepatic insulin resistance and it is accompanied by adipocyte hypertrophy and an elevated expression of different adipokines such as autotaxin (ATX).
Susann Fayyaz +8 more
doaj +1 more source
Spatio-temporal regulation of concurrent developmental processes by generic signaling downstream of chemokine receptors [PDF]
, 2018 Chemokines are secreted proteins that regulate a range of processes in eukaryotic organisms. Interestingly, different chemokine receptors control distinct biological processes, and the same receptor can direct different cellular responses, but the basis ...
Malhotra, Divyanshu +3 more
core +2 more sources
Lysophosphatidic acid (LPA) receptors: Signaling properties and disease relevance [PDF]
Prostaglandins & Other Lipid Mediators, 2010 Lysophosphatidic acid (LPA), a water-soluble phospholipid, has gained significant attention in recent years since the discovery that it acts as a potent signaling molecule with wide-ranging effects on many different target tissues. There are currently five identified G protein-coupled receptors for LPA and more are undergoing validation. The complexity
Mu-En, Lin, Deron R, Herr, Jerold, Chun
openaire +2 more sources
FEBS Open Bio, 2014 Fatty-acid-binding protein 3, muscle and heart (FABP3), also known as heart-type FABP, is a member of the family of intracellular lipid-binding proteins. It is a small cytoplasmic protein with a molecular mass of about 15 kDa.
Ryoko Tsukahara +3 more
doaj +1 more source
Journal of Lipid Research, 2020 Native interactions between lysophospholipids (LPs) and their cognate LP receptors are difficult to measure because of lipophilicity and/or the adhesive properties of lipids, which contribute to high levels of nonspecific binding in cell membrane ...
Manisha Ray +7 more
doaj +1 more source
Respiratory Research, 2021 Background Lysophosphatidic acid (LPA), generated extracellularly by the action of autotaxin and phospholipase A2, functions through LPA receptors (LPARs) or sphingosine-1-phosphate receptors (S1PRs) to induce pro-fibrotic signaling in the lower ...
Shyam Nathan +4 more
doaj +1 more source
Enhancing adult hippocampal neurogenesis with lysophosphatidic acid: a proposal for erasing cocaine contextual memory [PDF]
, 2018 Stimulating adult hippocampal neurogenesis (AHN) has been uncovered as a promising approach in the manipulation of retrograde memories. This work aims to study whether increasing AHN with lysophosphatidic acid (LPA, an endogenous lysophospholipid with ...
Castilla Ortega, María Estela +9 more
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