Results 81 to 90 of about 18,337 (203)

Expression profiles of TRPV1, TRPV4, TLR4 and ERK1/2 in the dorsal root ganglionic neurons of a cancer-induced neuropathy rat model

, 2018
Background: The spread of tumors through neural routes is common in several types of cancer in which patients suffer from a moderate-to-severe neuropathy, neural damage and a distorted quality of life.
Elsadek, Bakheet, Maqboul, Ahmad
core   +2 more sources

Translational research on autotaxin-LPA-LPA receptors and drug discovery

Clinical Lipidology, 2015
The discovery that lysophosphatidic acid (LPA) acts as a signaling molecule via its G protein-coupled receptors motivated studies on the signaling and pathophysiology of LPA. Furthermore, the subsequent identification of the LPA-producing plasma phosphodiesterase, autotaxin, led to structural and mouse genetic studies of this lysophospholipase D ...
openaire   +1 more source

Lysophosphatidic acid induces integrin activation in vascular smooth muscle and alters arteriolar myogenic vasoconstriction

Frontiers in Physiology, 2014
In vascular smooth muscle cells (VSMC) increased integrin adhesion to extracellular matrix (ECM) proteins, as well as the production of reactive oxygen species (ROS) are strongly stimulated by lysophosphatidic acid (LPA). We hypothesized that LPA-induced
Marius C. Staiculescu, Francisco I. Ramirez-Perez, Francisco I. Ramirez-Perez, Jorge A. Castorena-Gonzalez, Jorge A. Castorena-Gonzalez, Zhongkui eHong, Zhe eSun, Gerald A. Meininger, Gerald A. Meininger, Gerald A. Meininger, Luis A. Martinez-Lemus, Luis A. Martinez-Lemus, Luis A. Martinez-Lemus   +12 more
doaj   +1 more source

Selective inhibition of histamine-evoked Ca2+ signals by compartmentalized cAMP in human bronchial airway smooth muscle cells. [PDF]

, 2018
Intracellular Ca2+ and cAMP typically cause opposing effects on airway smooth muscle contraction. Receptors that stimulate these pathways are therapeutic targets in asthma and chronic obstructive pulmonary disease.
Dale, Philippa, Dowling, Mark R, Head, Victoria, Taylor, Colin W   +3 more
core   +1 more source

A genome-wide association meta-analysis on lipoprotein (a) concentrations adjusted for apolipoprotein (a) isoforms. [PDF]

, 2017
High lipoprotein (a) [Lp(a)] concentrations are an independent risk factor for cardiovascular outcomes. Concentrations are strongly influenced by apo(a) kringle IV repeat isoforms.
Bergmann, S., Coassin, S., Dähnhardt, D., Erhart, G., Forer, L., Gieger, C., Hunt, S.C., Kedenko, L., Kronenberg, F., Kähönen, M., Lamina, C., Lehtimäki, T., Mack, S., Marques-Vidal, P., Meitinger, T., Paulweber, B., Peters, A., Raitakari, O.T., Ried, J.S., Rueedi, R., Schönherr, S., Seppälä, I., Strauch, K., Stöckl, A., Vollenweider, P., Waeber, G., Yousri, N.A.   +26 more
core   +1 more source

Evaluation of pancreatic cancer cell migration with multiple parameters in vitro by using an optical real-time cell mobility assay device

BMC Cancer, 2017
Background Migration of cancer cell correlates with distant metastasis and local invasion, which are good targets for cancer treatment. An optically accessible device “TAXIScan” was developed, which provides considerably more information regarding the ...
Akira Yamauchi, Masahiro Yamamura, Naoki Katase, Masumi Itadani, Naoko Okada, Kayoko Kobiki, Masafumi Nakamura, Yoshiyuki Yamaguchi, Futoshi Kuribayashi   +8 more
doaj   +1 more source

Physiopathological Implications of 7TM Receptors [PDF]

, 2010
Seven-transmembrane (7TM) receptors are one of the most important proteins involved in perception of extracellular stimuli and regulation of variety of intracellular signaling pathways.
Cygankiewicz, Adam
core   +2 more sources

Preventing acute asthmatic symptoms by targeting a neuronal mechanism involving carotid body lysophosphatidic acid receptors

Nature Communications, 2018
Acute bronchoconstriction is the leading cause of asthmatic sudden death following allergen exposure. The authors show that the systemic increase of LPA following inhaled allergen or bradykinin challenge activates the carotid bodies through TRPV1 and LPA-
Nicholas G. Jendzjowsky, Arijit Roy, Nicole O. Barioni, Margaret M. Kelly, Francis H. Y. Green, Christopher N. Wyatt, Richard L. Pye, Luana Tenorio-Lopes, Richard J. A. Wilson   +8 more
doaj   +1 more source

Activation of lysophosphatidic acid receptor type 1 (LPA1) contributes to pathophysiology of spinal cord injury [PDF]

, 2015
Altres ajuts: NIH/NS084398Lysophosphatidic acid (LPA) is an extracellular lipid mediator involved in many physiological functions that signals through six known G-protein-coupled receptors (LPA1-LPA6).
Astudillo, Alma M., Balsinde, Jesús, Chun, Jerold, Estivill-Torrus, Guillermo, Hernández Martín, Joaquim, Lago Pérez, Natalia, López Vales, Rubén, López-Serrano, Clara, Rodríguez de Fonseca Fernando, Santos Nogueira, Eva   +9 more
core   +3 more sources

Effects of the LPA1 Receptor Deficiency and Stress on the Hippocampal LPA Species in Mice

Frontiers in Molecular Neuroscience, 2019
Lysophosphatidic acid (LPA) is an important bioactive lipid species that functions in intracellular signaling through six characterized G protein-coupled receptors (LPA1-6). Among these receptors, LPA1 is a strong candidate to mediate the central effects
Sara Tabbai, Román Dario Moreno-Fernández, Emma Zambrana-Infantes, Andrea Nieto-Quero, Jerold Chun, Maria García-Fernández, Guillermo Estivill-Torrús, Fernando Rodríguez de Fonseca, Luis Javier Santín, Tiago Gil Oliveira, Tiago Gil Oliveira, Margarita Pérez-Martín, Carmen Pedraza   +12 more
doaj   +1 more source