Results 111 to 120 of about 16,257 (211)
Modulation of LRP6‐mediated Wnt signaling by molecular chaperone Mesd
FEBS Letters, 2006 LRP6 is a Wnt coreceptor at the cell surface. Here, we report that a specialized molecular chaperone Mesd modulates LRP6‐mediated Wnt signaling and how different LRP6 mutants exhibit differential effects on Wnt signaling. We found that overexpression of increasing amounts of the full‐length LRP6 enhances Wnt signaling in a dose dependent manner only in
Li, Yonghe +3 more
openaire +3 more sources
Targeting self-renewal pathways in myeloid malignancies [PDF]
, 2013 A fundamental property of hematopoietic stem cells (HSCs) is the ability to self-renew. This is a complex process involving multiple signal transduction cascades which control the fine balance between self-renewal and differentiation through ...
Copland, M., Sands, W.A., Wheadon, H.
core +2 more sources
Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.Pan‐cancer analysis reveals an inflammatory phenotype remodeling of tissue‐resident macrophages (iTRM) in the tumor microenvironment, which is associated with immunosuppression. Tissue‐resident macrophages and monocyte‐derived macrophages exhibit convergent differentiation toward a similar inflammatory phenotype. iTRM‐enriched ecosystems are associated
Weikai Wang +19 more
wiley +1 more source
The Intersection of m6A Methylation and Immune Response in PCOS: A Bioinformatics Perspective
Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.N6‐methyladenosine RNA methylation regulators are intricately linked with the development of polycystic ovary syndrome (PCOS) and may influence immune cell infiltration in affected individuals. This study enhances our understanding of the molecular interactions in PCOS and suggests potential biomarkers for diagnosis and targets for therapeutic ...
Wenting Xu +8 more
wiley +1 more source
Genetic evidence that SOST inhibits WNT signaling in the limb [PDF]
, 1987 SOST is a negative regulator of bone formation, and mutations in human SOST are responsible for sclerosteosis. In addition to high bone mass, sclerosteosis patients occasionally display hand defects, suggesting that SOST may function embryonically.
Collette, Nicole M. +4 more
core +1 more source
Glycosylation of LRP6 regulates Wnt signaling
, 2015 This study provides the first evidence that a GlcNAc transferase modulates canonical Wnt signaling. Furthermore, this study indicates that this GlcNAc transferase is involved in metabolic regulation of Wnt signaling.
openaire +3 more sources
Osteocytes and mechanical loading: The Wnt connection [PDF]
, 2019 Bone adapts to the mechanical forces that it experiences. Orthodontic tooth movement harnesses the cell‐ and tissue‐level properties of mechanotransduction to achieve alignment and reorganization of the dentition.
Ahn Y +21 more
core +1 more source
Acta Pharmaceutica Sinica B, 2018 Whether and how garlic-derived S-allylmercaptocysteine (SAMC) inhibits hepatocellular carcinoma (HCC) is largely unknown. In the current study, the role of low-density lipoprotein receptor (LDLR)-related protein 6 (LRP6) in HCC progression and the anti ...
Jia Xiao +12 more
doaj +1 more source
Post-weaning blood transcriptomic differences between Yorkshire pigs divergently selected for residual feed intake [PDF]
, 2016 Meta data for RNA-seq and RT-qPCR assays.
Dekkers, Jack +5 more
core +13 more sources
Impaired neurodevelopmental pathways in autism spectrum disorder: a review of signaling mechanisms and crosstalk. [PDF]
, 2019 BackgroundThe development of an autistic brain is a highly complex process as evident from the involvement of various genetic and non-genetic factors in the etiology of the autism spectrum disorder (ASD). Despite being a multifactorial neurodevelopmental
Gu, Ran +5 more
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