Results 101 to 110 of about 16,257 (211)
Ethanol Affects Differentiation‐Related Pathways and Suppresses Wnt Signaling Protein Expression in Human Neural Stem Cells [PDF]
, 2012 Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/91167/1/j.1530-0277.2011.01682.x ...
Lyman, William D. +1 more
core +1 more source
The FASEB Journal, Volume 40, Issue 6, 31 March 2026.FNDC1 competitively binds Gβ2 to suppress the β‐catenin–destruction complex and promote the malignant behavior of gastric cancer (GC) by the following mechanism: elevated FNDC1 competes with Dvl for binding to Gβ2, thereby reducing Dvl–Gβ2 interaction; this reduction inhibits Dvl degradation in the cytoplasm; increased Dvl recruits Axin1, thereby ...
Wenyu Gao +9 more
wiley +1 more source
Cloning and expression of Xenopus Lrp5 and Lrp6 genes
Mechanisms of Development, 2002 LRP5 and LRP6 comprise a subfamily of lipoprotein-receptor related proteins that function as co-receptors for Wnt proteins. Mutation of human LRP5 is responsible for osteoporosis-pseudoglioma syndrome and disruption of Lrp6 in mice causes similar effects to mutation of several different Wnt genes.
Houston, Douglas W, Wylie, Chris
openaire +2 more sources
Gigantol inhibits Wnt/β-catenin signaling and exhibits anticancer activity in breast cancer cells
BMC Complementary and Alternative Medicine, 2018 Background Gigantol is a bibenzyl compound derived from several medicinal orchids. This biologically active compound has been shown to have promising therapeutic potential against cancer cells, but its mechanism of action remains unclear.
Shubin Yu +13 more
doaj +1 more source
Scientific Reports, 2020 The canonical Wnt pathway serves as a hub connecting diverse cellular processes, including β-catenin signaling, differentiation, growth, protein stability, macropinocytosis, and nutrient acquisition in lysosomes.
Gabriele Colozza +7 more
doaj +1 more source
The FASEB Journal, Volume 40, Issue 5, 15 March 2026.Single‐cell transcriptomic profiling reveals that endometrial polyps arise from estrogen‐driven disruption of stromal‐epithelial signaling. Stromal cells exhibit enhanced WNT, IGF, and VEGF pathways, promoting epithelial proliferation and vascular remodeling.
Tingwei Chen +12 more
wiley +1 more source
Journal of Cellular and Molecular Medicine, Volume 30, Issue 5, March 2026.ABSTRACT Most cancer cells rely on aerobic glycolysis to support uncontrolled proliferation and evade apoptosis and switch to glutamine metabolism to survive under hypoxic conditions. In hepatocellular carcinoma (HCC), the Wnt/β‐catenin pathway acts as a critical driver of metabolic reprogramming and stemness, primarily by enhancing aerobic glycolysis ...
Sanjit K. Roy +5 more
wiley +1 more source
Near-membrane ensemble elongation in the proline-rich LRP6 intracellular domain may explain the mysterious initiation of the Wnt signaling pathway [PDF]
, 2011 10.1186/1471-2105-12-S13-S13BMC Bioinformatics12SUPPL.
Chengcheng Liu +2 more
core +2 more sources
Cancer Medicine, Volume 15, Issue 2, February 2026.ABSTRACT Objective Irinotecan, a standard therapeutic agent for metastatic colorectal cancer (mCRC), often faces significant limitations due to drug resistance, with treatment failure observed in approximately 30%–50% of patients, leading to poor clinical outcomes.
Yi Pan +9 more
wiley +1 more source
Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation [PDF]
, 2006 The planar cell polarity (PCP) pathway is conserved throughout evolution, but it mediates distinct developmental processes. In Drosophila, members of the PCP pathway localize in a polarized fashion to specify the cellular polarity within the plane of the
Brinkman, Brendan C. +9 more
core +1 more source