Results 81 to 90 of about 16,257 (211)

Pathophysiology and Molecular Signalling in Osteoporosis: Linking Risk Factors to Bone Loss

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Osteoporosis is a prevalent skeletal disorder characterised by progressive reduction in bone mass, microarchitectural deterioration, and increased fracture susceptibility. In India, approximately one‐third of the elderly population is affected by bone‐related disorders, and the global burden of osteoporosis continues to rise.
Pramoda G., Kamini Shivhare, Piyush Kumar Gupta, Amirhossein Sahebkar, Prashant Kesharwani, Rahul Shukla   +5 more
wiley   +1 more source

Transmembrane Protein 198 Promotes LRP6 Phosphorylation and Wnt Signaling Activation [PDF]

Molecular and Cellular Biology, 2011
Wnt/β-catenin signaling is fundamental in embryogenesis and tissue homeostasis in metazoans. Upon Wnt stimulation, cognate coreceptors LRP5 and LRP6 ([LRP5/6] low-density lipoprotein receptor-related proteins 5 and 6) are activated via phosphorylation at key residues.
Juan, Liang, Yu, Fu, Cristina-Maria, Cruciat, Shunji, Jia, Ying, Wang, Zhen, Tong, Qinghua, Tao, Dierk, Ingelfinger, Michael, Boutros, Anming, Meng, Christof, Niehrs, Wei, Wu   +11 more
openaire   +2 more sources

LRP6 Is a Functional Receptor for Attenuated Canine Distemper Virus

mBio, 2023
Oncolytic viruses (OV) have gathered increasing interest in recent years as an alternative option to treat cancers. The Onderstepoort strain of canine distemper virus (CDV-OP), an enveloped RNA virus belonging to the genus Morbillivirus , is employed as a safe and efficient vaccine for dogs against distemper disease.
Gradauskaite, Vaiva, Inglebert, Marine, Doench, John, Scherer, Melanie, Dettwiler, Martina, Wyss, Marianne, Shrestha, Neeta, Rottenberg, Sven, Plattet, Philippe   +8 more
openaire   +4 more sources

Sclerostin inhibits Wnt signaling through tandem interaction with two LRP6 ectodomains

Nature Communications, 2020
The low-density lipoprotein receptor-related protein 6 (LRP6) is a co-receptor of the β-catenin-dependent Wnt signaling pathway and interacts with the Wnt inhibitor sclerostin (SOST). Here the authors present the crystal structure of SOST in complex with
Jinuk Kim, Wonhee Han, Taeyong Park, Eun Jin Kim, Injin Bang, Hyun Sik Lee, Yejing Jeong, Kyeonghwan Roh, Jeesoo Kim, Jong-Seo Kim, Chanhee Kang, Chaok Seok, Jin-Kwan Han, Hee-Jung Choi   +13 more
doaj   +1 more source

A potential role for Dkk-1 in the pathogenesis of osteosarcoma predicts novel diagnostic and treatment strategies. [PDF]

, 2007
Canonical Wnt signaling is an osteo-inductive signal that promotes bone repair through acceleration of osteogenic differentiation by progenitors. Dkk-1 is a secreted inhibitor of canonical Wnt signaling and thus inhibits osteogenesis.
Angela Smolarz, Carl Gregory, Darwin Prockop, Edwin Horwitz, Jacob Reiser, Najat Daw, Narae Lee, Odile David, Robert Kutner, Scott Olson   +9 more
core   +3 more sources

A Conformal Wearable Ultrasound Bioelectronics for Mechanotherapy Reprogramming of Fibroblast Plasticity via Wnt‐FGF10 Axis to Overcome Fibrotic Healing in Urethral Regeneration

Advanced Science, Volume 13, Issue 24, 27 April 2026.
Fibrotic scarring persistently challenges urethral reconstruction. This study introduces a conformal, wearable ultrasound bioelectronic system that overcomes this by reprogramming fibroblast fate. The device activates a developmental Wnt–FGF10 axis, driving fibroblasts toward a regenerative FGF10+ phenotype that promotes angiogenesis and matrix ...
Mingming Yu, Xingxuan Zhang, Huan Zhang, Jun Wang, Fang Chen, Xiaojun Cai, Yichen Huang, Yuanyi Zheng   +7 more
wiley   +1 more source

Wnt3a-Mediated Formation of Phosphatidylinositol 4,5-Bisphosphate Regulates LRP6 Phosphorylation [PDF]

Science, 2008
The canonical Wnt–β-catenin signaling pathway is initiated by inducing phosphorylation of one of the Wnt receptors, low-density lipoprotein receptor-related protein 6 (LRP6), at threonine residue 1479 (Thr 1479 ) and serine residue 1490 (Ser 1490 ).
Weijun, Pan, Sun-Cheol, Choi, He, Wang, Yuanbo, Qin, Laura, Volpicelli-Daley, Laura, Swan, Louise, Lucast, Cynthia, Khoo, Xiaowu, Zhang, Lin, Li, Charles S, Abrams, Sergei Y, Sokol, Dianqing, Wu   +12 more
openaire   +2 more sources

Impaired LRP6-TCF7L2 Activity Enhances Smooth Muscle Cell Plasticity and Causes Coronary Artery Disease

Cell Reports, 2015
Mutations in Wnt-signaling coreceptor LRP6 have been linked to coronary artery disease (CAD) by unknown mechanisms. Here, we show that reduced LRP6 activity in LRP6R611C mice promotes loss of vascular smooth muscle cell (VSMC) differentiation, leading to
Roshni Srivastava, Jiasheng Zhang, Gwang-woong Go, Anand Narayanan, Timothy P. Nottoli, Arya Mani   +5 more
doaj   +1 more source

Whole exome sequencing in an Italian family with isolated maxillary canine agenesis and canine eruption anomalies [PDF]

, 2018
Objective: The aim of this study was the clinical and molecular characterization of a family segregating a trait consisting of a phenotype specifically involving the maxillary canines, including agenesis, impaction and ectopic eruption, characterized by ...
Barbato, Ersilia, Caputo, Viviana, Ciolfi, Andrea, Di Giorgio, Roberto, Genovesi, Maria Luce, Giovannetti, Agnese, Guarnieri, Rosanna, Magliozzi, Maria Rosa, Paolacci, Stefano, Pizzi, Simone, Pizzuti, Antonio, Tartaglia, Marco, Traversa, Alice   +12 more
core   +1 more source

FGFR1 Promotes Malignant Progression in Lung Squamous Cell Carcinoma Through Activation of Wnt/β‐Catenin Signaling

Cancer Medicine, Volume 15, Issue 4, April 2026.
ABSTRACT Objectives This study aims to elucidate the role of FGFR1 in activating the Wnt/β‐catenin signaling pathway and the underlying mechanisms by which it promotes malignant progression in lung squamous cell carcinoma (LUSC). By integrating multi‐omics analysis with functional experiments, the clinical heterogeneity of FGFR1 amplification ...
Xingyuan Li, Shuya Mu, Yinjia Sun, Yongfeng Yu   +3 more
wiley   +1 more source