Results 71 to 80 of about 16,257 (211)
Vascular Calcification: Mechanisms, Models, and Therapies
iNew Medicine, EarlyView.ABSTRACT Vascular calcification represents an active multifactorial process that mirrors several key features of skeletal bone mineralization. Clinically, it is characterized by diminished arterial compliance and increased arterial wall stiffness, both of which serve as independent predictors of significant adverse cardiovascular events.
Wenya Zhu +5 more
wiley +1 more source
Cellular & Molecular Biology Letters, 2023 Background Mechanotransduction mechanisms whereby periodontal ligament stem cells (PDLSCs) translate mechanical stress into biochemical signals and thereby trigger osteogenic programs necessary for alveolar bone remodeling are being deciphered.
Jixiao Wang +6 more
doaj +1 more source
EGFR is required for Wnt9a-Fzd9b signalling specificity in haematopoietic stem cells. [PDF]
, 2019 Wnt signalling drives many processes in development, homeostasis and disease; however, the role and mechanism of individual ligand-receptor (Wnt-Frizzled (Fzd)) interactions in specific biological processes remain poorly understood. Wnt9a is specifically
Barahona, Rocio +14 more
core
Behind the scenes: how the EMILIN/Multimerin family shapes the cancer landscape
The FEBS Journal, EarlyView.The EMILIN/Multimerin family members regulate key hallmarks of cancer—including apoptosis, angiogenesis, metastasis, and tumor microenvironment remodeling. As indicated, their function in immune evasion, drug resistance, and metabolic reprogramming remains largely unexplored.
Evelina Poletto +9 more
wiley +1 more source
MicroRNA-610 inhibits tumor growth of melanoma by targeting LRP6 [PDF]
Oncotarget, 2017 Accumulating evidence showed that aberrant miRNAs expression was involved in initiation and progression of melanoma. However, the investigation of different miRNAs in melanoma remain attractive. In this research, we demonstrated that miR-610 expression was decreased in melanoma tissues and cell lines.
Zhang, Guangjing +5 more
openaire +2 more sources
A plasmid-based system for expressing small interfering RNA libraries in mammalian cells [PDF]
, 2004 Background RNA interference (RNAi) is an evolutionarily conserved process that functions to inhibit gene expression. The use of RNAi in mammals as a tool to study gene function has rapidly developed in the last couple of years since the discovery that ...
Ajamete Kaykas, Randall T Moon
core +2 more sources
Targeted Therapy and Immunotherapies in Hepatocellular Carcinoma: Mechanisms and Clinical Studies
MedComm, Volume 7, Issue 5, May 2026.The mechanism of multiple signaling pathways and their related targeted inhibitors in HCC. (A) The mechanism of Ras/Raf/MEK/ERK signaling pathway and its related targeted inhibitors; (B) the mechanism of PI3K/AKT/mTOR signaling pathway and its crosstalk with other pathways and its related targeted inhibitors; (C) the mechanism of JAK/STAT signaling ...
Penghui He +9 more
wiley +1 more source
Aging Cell, Volume 25, Issue 5, May 2026.Plasma dilution at 24 h after I/R improved cardiac remodeling, function, and the physical performance of old male and female mice, through lowered markers of inflammation, fibrosis, reduction of cardiomyocytes' apoptosis, increase in their cell‐cycle re‐entry, and healthier profile of newly synthesized proteome, including the determinants of Jak/Stat ...
Joana Marie C. Cruz +11 more
wiley +1 more source
Frontiers in Cardiovascular Medicine, 2022 Low-density lipoprotein receptor-related protein 6 (LRP6) plays a critical role in cardiovascular homeostasis. The deficiency of LRP6 is associated with a high risk of arrhythmias.
Qi Guo +9 more
doaj +1 more source
Sulf1 has ligand-dependent effects on canonical and non-canonical Wnt signalling [PDF]
, 2015 Wnt signalling plays essential roles during embryonic development and is known to be mis-regulated in human disease. There are many molecular mechanisms that ensure tight regulation of Wnt activity.
Ai +80 more
core +2 more sources