DKK1 Positively Correlates with Lung Function in COPD Patients and Reduces Airway Inflammation
International Journal of COPD, 2022 Luqi Dai,1,2,* Dan Xu,1,* Chun Wan,1,2 Lian Liu,1 Fuqiang Wen1,2 1Division of Pulmonary Diseases, State Key Laboratory of Biotherapy, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, Sichuan, People’s Republic of ...
Dai L, Xu D, Wan C, Liu L, Wen F
doaj
Mice with a heterozygous Lrp6 deletion have impaired fracture healing [PDF]
Bone Research, 2016 AbstractBone fracture non-unions, the failure of a fracture to heal, occur in 10%–20% of fractures and are a costly and debilitating clinical problem. The Wnt/β-catenin pathway is critical in bone development and fracture healing. Polymorphisms of linking low-density lipoprotein receptor-related protein 6 (LRP6), a Wnt-binding receptor, have been ...
Burgers, Travis A. +5 more
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A 5`-tRNA Derived Fragment NamedtiRNA-Val-CAC-001 Works as a Suppressor in Gastric Cancer
Cancer Management and Research, 2022 Junyu Zheng, Cong Li, Zining Zhu, Fengming Yang, Xiaoming Wang, Pan Jiang, Feng Yan Department of Clinical Laboratory, The Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing,
Zheng J +6 more
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The function of endocytosis in Wnt signaling [PDF]
, 2017 This is the final version of the article. Available from Springer Verlag via the DOI in this record.Wnt growth factors regulate one of the most important signaling networks during development, tissue homeostasis and disease.
Brunt, L, Scholpp, S
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Lrp5 and Lrp6 exert overlapping functions in osteoblasts during postnatal bone acquisition. [PDF]
PLoS ONE, 2013 The canonical Wnt signaling pathway is critical for skeletal development and maintenance, but the precise roles of the individual Wnt co-receptors, Lrp5 and Lrp6, that enable Wnt signals to be transmitted in osteoblasts remain controversial.
Ryan C Riddle +6 more
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Tumor promoter TPA activates Wnt/β-catenin signaling in a casein kinase 1-dependent manner. [PDF]
, 2018 The tumor promoter 12-O-tetra-decanoylphorbol-13-acetate (TPA) has been defined by its ability to promote tumorigenesis on carcinogen-initiated mouse skin.
Carson, Dennis A +12 more
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Coronectomy of deeply impacted lower third molar : incidence of outcomes and complications after one year follow-up [PDF]
, 2015 Objectives: The purpose of present study was to assess the surgical management of impacted third molar with proximity to the inferior alveolar nerve and complications associated with coronectomy in a series of patients undergoing third molar surgery ...
Ajbage, Jimoh Olubanwo +6 more
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Exploration, EarlyView.Amphibian‐derived peptide RL‐QN15 activates the Wnt/β‐catenin signaling pathway by interacting with the FZD8 membrane receptor, promoting epidermal stem cells proliferation, migration, stemness, and EMT processes, thus promoting skin wound healing.
Yuansheng Li +15 more
wiley +1 more source
The First Propeller Domain of LRP6 Regulates Sensitivity to DKK1 [PDF]
Molecular Biology of the Cell, 2009 The Wnt coreceptor LRP6 is required for canonical Wnt signaling. To understand the molecular regulation of LRP6 function, we generated a series of monoclonal antibodies against the extra cellular domain (ECD) of LRP6 and selected a high-affinity mAb (mAb135) that recognizes cell surface expression of endogenous LRP6.
Minke E, Binnerts +15 more
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High-bone-mass causing mutant LRP5 receptors are resistant to endogenous inhibitors in vivo [PDF]
, 2015 Certain missense mutations affecting LRP5 cause high bone mass (HBM) in humans. Based on in vitro evidence, HBM LRP5 receptors are thought to exert their effects by providing resistance to binding/inhibition of secreted LRP5 inhibitors such as sclerostin
Bellido, Teresita +7 more
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