Results 121 to 130 of about 16,257 (211)
Ixazomib enhances parathyroid hormone-induced β-catenin/T-cell factor signaling by dissociating β-catenin from the parathyroid hormone receptor. [PDF]
, 2017 The anabolic action of PTH in bone is mostly mediated by cAMP/PKA and Wnt-independent activation of β-catenin/T-cell factor (TCF) signaling. β-Catenin switches the PTH receptor (PTHR) signaling from cAMP/PKA to PLC/PKC activation by binding to the PTHR ...
Lei, Hong +3 more
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VSTM2A suppresses colorectal cancer and antagonizes Wnt signaling receptor LRP6
Theranostics, 2019 Hyperactivation of Wnt/β-catenin signaling pathway is a critical step in colorectal tumorigenesis. In this study, we identified that V-set and transmembrane domain containing 2A (VSTM2A) was a top-downregulated secreted protein that negatively regulated Wnt singling pathways in colorectal cancer (CRC).
Dong, Yujuan +14 more
openaire +2 more sources
Lrp6/F-Actin Axis Drives Mechano-Osteogenesis In Pdlscs
International Dental JournalAim or purpose: The unclear function of Low-density lipoprotein receptor-related protein 6 (LRP6) in periodontal ligament stem cells (PDLSCs) mechanotransduction of osteogenic signals requires exploration to uncover its mechanistic impact on bone ...
Fulan Wei, Jixiao Wang
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Pharmacological ResearchAtherosclerotic-related acute cardiovascular events remain a leading cause of mortality worldwide, yet there are currently no pharmacological interventions available to address plaque formation or plaque rupture (PR). Here we reported that gentisic acid (
Tongqing Chen +11 more
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Cell Reports, 2013 Genetic screens in invertebrates have discovered many synaptogenic genes and pathways. However, similar genetic studies have not been possible in mammals.
Kamal Sharma +6 more
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The Genetic Signature of Perineuronal Oligodendrocytes [PDF]
, 2008 Oligodendrocytes in the central nervous system can be categorized as precursors, myelin-forming, and non-myelinating perineuronal cells. The function of perineuronal oligodendrocytes is unknown; it was proposed that following injury, they may remyelinate
Dragan Maric +5 more
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Investigating the Interactions Between Protocadherin-19 and Ryk and its Effect on Neurogenesis [PDF]
, 2016 Protocadherins are a large, diverse family of neural cell adhesion proteins, but their functions are not understood. Mutations or in several protocadherins have been associated with neurological disorders.
Liebau, Brandon
core
miR-16-5p调控Wnt/β-catenin通路活性在力学载荷促进骨形成中作用的小鼠在体研究
Zhongguo shiyan zhenduanxue目的 探究LRP6是否为miR-16-5p靶基因及miR-16-5p调控Wnt/β-catenin通路活性在力学载荷促进小鼠骨形成中的作用。方法 利用microRNA信息库预测miR-16-5p的靶基因，行荧光素酶报告实验来验证LRP6是否为miR-16-5p的靶基因。构建跑台组和对照组小鼠验证不同力学环境下骨组织中miR-16-5p及LRP6是否差异表达。制造miR-16-5p差异表达及力学加载动物模型：正常+miRNA Agomir control组(A组)、正常+miR-16-5p Agomir组(
贾浩波 +3 more
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Journal of Ideas in Health, 2019 Background: Human lipoprotein receptor-related protein -6 (LRP6) plays a role in the development of coronary artery disease. This study aimed to determine the serum level of the LRP6 in patients referred to the coronary angiogram taking into ...
Adil Hassan Alhusseiny +2 more
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