Results 101 to 110 of about 27,519 (289)

RB1 inactivation in cutaneous carcinomas

Histopathology, EarlyView.
Among skin carcinomas, recurrent RB1 inactivation is observed in Merkel cell carcinoma, in a subset of squamous cell carcinoma with bowenoid morphology, in sebaceous carcinoma and in the recently described Wnt/beta‐catenin rosette‐forming carcinoma.
Tiffany Liv, Antoine Touzé, David Schrama, Serge Guyétant, Mahtab Samimi, Michael T Tetzlaff, Benjamin A Wood, Paul W Harms, Thibault Kervarrec   +8 more
wiley   +1 more source

Biogenic retrograde signaling via GUN1 ensures thermotolerant chloroplast biogenesis during seedling establishment in Arabidopsis thaliana

Journal of Integrative Plant Biology, EarlyView.
Under heat stress, GENOMES UNCOUPLED1 (GUN1) is crucial for the formation of functional chloroplasts in seedlings under heat stress. Without GUN1, chloroplast development fails and seedlings fail to turn green. Therefore, GUN1 helps relay heat‐related cues to maintain chloroplast biogenesis and support thermotolerance during early growth.
Shan Qi, Chaojun Cui, Jieya Xia, Mengping Li, Mengshuang Li, Jong‐Seong Jeon, Chanhong Kim   +6 more
wiley   +1 more source

Allelic Variation in Maize Malate Dehydrogenase 7 Shapes Promoter Methylation and Banded Leaf and Sheath Blight Resistance

Advanced Science, Volume 13, Issue 7, 3 February 2026.
In this study maize chloroplastic malate dehydrogenase7 (ZmMDH7), is identified as a Rhizoctonia solani resistance gene in maize. ZmMDH7 is regulated by transcription factor ZmWRKY44 via pathogens challenge to elevate mitochondrial ROS and SA signaling pathway.
Luyang Wei, Junbin Chen, Chuang Liu, DanDan Liu, Meida Du, Shengfeng He, Wenyu Cheng, Vijai Bhadauria, You‐Liang Peng, Wangsheng Zhu   +9 more
wiley   +1 more source

Discovery of novel sulphonamide hybrids that inhibit LSD1 against bladder cancer cells

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Aim:A series of sulphonamide hybrids were designed, synthesised, and identified as potential lysine-specific demethylase 1 (LSD1) inhibitors.Materials and methods: Bladder cancer cell lines were cultured to evaluate the antiproliferative activity ...
Jia Liu, Xingwang Zhu, Liu Yu, Minghuan Mao   +3 more
doaj   +1 more source

The faah gene is the first direct target of estrogen in the testis: role of histone demethylase LSD1 [PDF]

, 2012
Estrogen (E(2)) regulates spermatogenesis, yet its direct target genes have not been identified in the testis. Here, we cloned the proximal 5' flanking region of the mouse fatty acid amide hydrolase (faah) gene upstream of the luciferase reporter gene ...
Di Giacomo, D, Di Siena, S, Geremia, R, Grimaldi, P, Maccarrone, M, Pirazzi, V, Pucci, M   +6 more
core   +1 more source

DNTTIP1 drives leukaemogenesis through MiDAC‐mediated epigenetic silencing of BMF

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
DNTTIP1 cooperates with SP1 to recruit HDAC1/2, leading to BMF silencing and reduced competitive binding of BMF to BCL2.This suppresses autophagy and apoptosis, promoting leukaemic cell survival. Targeting the DNTTIP1‐HDAC1/2‐BMF axis reactivates BMF and induces anti‐leukaemic effects.
Ruolin Xiu, Yuzhu Ma, Yueying Gao, Yao Chen, Xinyu Li, Yue Wu, Meiling Sun, Qizhao Li, Yanhong Zhao, Shuqian Xu, Shengjin Fan, Yongsheng Li, Huitao Fan   +12 more
wiley   +1 more source

The deubiquitinase USP38 affects cellular functions through interacting with LSD1

Biological Research, 2018
Background Deubiquitination is a posttranslational protein modification prevalent in mammalian cells. Deubiquitinases regulate the functions of the target protein by removing its ubiquitin chain.
Wenbin Liu, Qi Zhang, Yuanyuan Fang, Yanan Wang   +3 more
doaj   +1 more source

LSD1 inhibition modulates transcription factor networks in myeloid malignancies

Frontiers in Oncology, 2023
Acute Myeloid Leukemia (AML) is a type of cancer of the blood system that is characterized by an accumulation of immature hematopoietic cells in the bone marrow and blood.
Emily E. Hartung, Kanwaldeep Singh, T. Berg   +2 more
semanticscholar   +1 more source

Bufalin Inhibits Cytokine Storm by Regulating TLR4/TLR3 Signaling Pathway

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
ABSTRACT Background Bufalin is one main component of the dried venom from Bufo gargarizans Cantor, which has anti‐tumor, cardiotonic, anti‐inflammatory and other physiological activities. However, in recent years, researchers have mainly paid attention to its anti‐tumor effect and neglected its anti‐inflammatory effect.
Xixi Liu, Chencheng Li, Jing Yang, Weiguang Zhang, Zhongxiao Hu, Xiaoli Zhang, Reaila Jianati, Fang Tian, Xingbin Dai, Zuqiong Xu, Biqing Chen, Xuejun Zhu   +11 more
wiley   +1 more source

LSD1 inhibition circumvents glucocorticoid-induced muscle wasting of male mice

Nature Communications
Synthetic glucocorticoids (GC), such as dexamethasone, are extensively used to treat chronic inflammation and autoimmune disorders. However, long-term treatments are limited by various side effects, including muscle atrophy. GC activities are mediated by
Qingshuang Cai, Rajesh Sahu, Vanessa Ueberschlag-Pitiot, Sirine Souali-Crespo, Céline Charvet, Ilyes Silem, F. Cottard, Tao Ye, Fatima Taleb, Eric Metzger, R. Schuele, Isabelle M L Billas, Gilles Laverny, Daniel Metzger, D. Duteil   +14 more
semanticscholar   +1 more source