Results 101 to 110 of about 12,929 (212)

Nuclear Receptor-Enhanced Transcription Requires Motor- and LSD1-Dependent Gene Networking in Interchromatin Granules [PDF]

, 2008
Esperanza Núñez, Young‐Soo Kwon, Kasey R. Hutt, Qidong Hu, Maria Dafne Cardamone, Kenneth A. Ohgi, Ivan García-Bassets, David W. Rose, Christopher K. Glass, Michael G. Rosenfeld, Xiangdong Fu   +10 more
openalex   +1 more source

412 Synergistic Targeting of Lysine-specific demethylase 1 (LSD1) and MAPK Signaling: A Mechanism-Guided Therapeutic Approach for Glioblastoma (GBM)

Journal of Clinical and Translational Science
OBJECTIVES/GOALS: LSD1 is a histone demethylase important in GBM regulation. Our goal is to design a therapeutic strategy for LSD1 inhibitors to meet clinical needs in GBM. Despite the abundance of LSD1 inhibitors, resistance emerges in GBM mouse models.
Lea Stitzlein, Jack Adams, Matthew Luetzen, Melissa Singh, Xioaping Su, Yue Lu, Joy Gumin, Frederick Lang, Joya Chandra   +8 more
doaj   +1 more source

ASXL1 Represses Retinoic Acid Receptor-mediated Transcription through Associating with HP1 and LSD1 [PDF]

, 2009
Sang-Wang Lee, Yang-Sook Cho, Jung-Min Na, Ui‐Hyun Park, Myengmo Kang, Eunjoo Kim, Soo‐Jong Um   +6 more
openalex   +1 more source

Structural insight into inhibitors of flavin adenine dinucleotide-dependent lysine demethylases

Epigenetics, 2017
Until 2004, many researchers believed that protein methylation in eukaryotic cells was an irreversible reaction. However, the discovery of lysine-specific demethylase 1 in 2004 drastically changed this view and the concept of chromatin regulation.
Hideaki Niwa, Takashi Umehara
doaj   +1 more source

Thermodynamic Characterization of the Binding Interaction between the Histone Demethylase LSD1/KDM1 and CoREST [PDF]

, 2010
Sun‐Hee Hwang, Allison A. Schmitt, Andrea E. Luteran, Eric J. Toone, Dewey G. McCafferty   +4 more
openalex   +1 more source

Exploration of 5-cyano-6-phenylpyrimidin derivatives containing an 1,2,3-triazole moiety as potent FAD-based LSD1 inhibitors

Acta Pharmaceutica Sinica B, 2020
Histone lysine specific demethylase 1 (LSD1) has become a potential therapeutic target for the treatment of cancer. Discovery and develop novel and potent LSD1 inhibitors is a challenge, although several of them have already entered into clinical trials.
Liying Ma, Haojie Wang, Yinghua You, Chaoya Ma, Yuejiao Liu, Feifei Yang, Yichao Zheng, Hongmin Liu   +7 more
doaj  

Endogenous retroviruses and neighboring genes are coordinately repressed by LSD1/KDM1A [PDF]

, 2011
Todd S. Macfarlan, Wesley D. Gifford, Saurabh Agarwal, Shawn P. Driscoll, Karen Lettieri, Jianxun Wang, Shane E. Andrews, Laura Franco, Michael G. Rosenfeld, Bing Ren, Samuel L. Pfaff   +10 more
openalex   +1 more source

Role of androgen receptor and associated lysine‐demethylase coregulators, LSD1 and JMJD2A, in localized and advanced human bladder cancer [PDF]

, 2011
Eric Kauffman, Brian D. Robinson, Martin Downes, Leagh Powell, Ming Ming Lee, Douglas S. Scherr, Lorraine J. Gudas, Nigel P. Mongan   +7 more
openalex   +1 more source

A SIRT1-LSD1 Corepressor Complex Regulates Notch Target Gene Expression and Development [PDF]

, 2011
Peter Mulligan, Fajun Yang, Luisa Di Stefano, Jun‐Yuan Ji, Jian Ouyang, Joy L. Nishikawa, Debra Toiber, Madhura Kulkarni, Qun Wang, S. Hani Najafi‐Shoushtari, Raúl Mostoslavsky, Steven P. Gygi, Grace Gill, Nicholas J. Dyson, Anders M. Näär   +14 more
openalex   +1 more source

Triptolide induces cell-cycle arrest and apoptosis of human multiple myeloma cells in vitro via altering expression of histone demethylase LSD1 and JMJD2B [PDF]

, 2011
Lu Wen, Chen Yan, Zeng Linglan, Fei Zhao, Rui Li, Yuan Liu, Chun Zhang   +6 more
openalex   +1 more source