Results 111 to 120 of about 24,350 (247)
The Transcription Factor TWIST‐Related Protein 1 in Atherosclerosis
iNew Medicine, Volume 1, Issue 1, December 2025.ABSTRACT TWIST‐related protein 1 (TWIST1), a basic helix–loop–helix transcription factor, participates in embryonic development and tissue homeostasis. TWIST1 significantly contributes to the pathogenesis of vascular disorders, including pulmonary arterial hypertension, tumor angiogenesis, obesity, and ocular angiogenesis. Functioning as a shear stress‐
Xiuying Li +5 more
wiley +1 more source
DDRE-23. PRECLINICAL EVALUATION OF BRAIN PENETRATION PROPERTIES OF NEW FIRST-IN-CLASS LYSINE-SPECIFIC DEMETHYLASE 1 (LSD1) INHIBITOR, SP-2577 [PDF]
, 2021 Jun Jiang +7 more
openalex +1 more source
Epigenetic regulators as promising therapeutic targets in acute myeloid leukemia. [PDF]
, 2015 Acute myeloid leukemia (AML), the most prevalent acute leukemia in adults, is an aggressive hematological malignancy arising in hematopoietic stem and progenitor cells.
Gallipoli, Paolo +2 more
core +2 more sources
Tumor Cell Plasticity in Cancer: Signaling Pathways and Pharmaceutical Interventions
MedComm, Volume 6, Issue 12, December 2025.Cell plasticity refers to a dynamic program through which cells reprogram their phenotype, acquiring new histologic and molecular characteristics. Recognized as a hallmark of cancer, cellular plasticity plays a critical role in tumor evolution.
Shangwei Sun +7 more
wiley +1 more source
LSD1 Interacts with Zfp516 to Promote UCP1 Transcription and Brown Fat Program
Cell Reports, 2016 Zfp516, a brown fat (BAT)-enriched and cold-inducible transcription factor, promotes transcription of UCP1 and other BAT-enriched genes for non-shivering thermogenesis. Here, we identify lysine-specific demethylase 1 (LSD1) as a direct binding partner of
Audrey Sambeat +6 more
doaj +1 more source
Characterization of the Epigenetic Changes During Human Gonadal Primordial Germ Cells Reprogramming [PDF]
, 2016 Epigenetic reprogramming is a central process during mammalian germline development. Genome-wide DNA demethylation in primordial germ cells (PGCs) is a prerequisite for the erasure of epigenetic memory, preventing the transmission of epimutations to the ...
Eguizábal, Cristina +5 more
core +1 more source
Histone H3 peptide based LSD1-selective inhibitors
Bioorganic & Medicinal Chemistry Letters, 2015 A series of candidates for the histone H3 peptide based LSD1-selective inhibitor were designed and synthesized. Among peptides 1a-c and 2a-c, peptide 1a, which has a phenylcyclopropylamine (PCPA) moiety at Lys-4 of the 21 amino acid residues of histone H3, was the most potent LSD1-selective inhibitor.
Taeko, Kakizawa +4 more
openaire +3 more sources
Cell Death DiscoveryBone metastasis is a key contributor to morbidity and mortality of breast cancer patients. We have previously shown that exosomal miRNAs derived from LSD1 knockdown (KD) breast cancer cells inhibit osteoblast differentiation and promote osteoclast ...
Ziyu Liu +8 more
doaj +1 more source
Alteration of Epigenetic Regulation by Long Noncoding RNAs in Cancer [PDF]
, 2018 Long noncoding RNAs (lncRNAs) are important regulators of the epigenetic status of the human genome. Besides their participation to normal physiology, lncRNA expression and function have been already associated to many diseases, including cancer.
Fatica, Alessandro, Morlando, Mariangela
core +2 more sources