Results 121 to 130 of about 24,350 (247)

Lysine specific demethylase 1 inactivation enhances differentiation and promotes cytotoxic response when combined with all-trans retinoic acid in acute myeloid leukemia across subtypes

Haematologica, 2019
Lysine specific demethylase 1 (LSD1) is a histone modifying enzyme that suppresses gene expression through demethylation of lysine 4 on histone H3. The anti-tumor activity of GSK2879552 and GSK-LSD1, potent, selective irreversible inactivators of LSD1 ...
Kimberly N. Smitheman, Tesa M. Severson, Satyajit R. Rajapurkar, Michael T. McCabe, Natalie Karpinich, James Foley, Melissa B. Pappalardi, Ashley Hughes, Wendy Halsey, Elizabeth Thomas, Christopher Traini, Kelly E. Federowicz, Jenny Laraio, Fredrick Mobegi, Geraldine Ferron-Brady, Rabinder K. Prinjha, Christopher L. Carpenter, Ryan G. Kruger, Lodewyk Wessels, Helai P. Mohammad   +19 more
doaj   +1 more source

P1649: GFI1B AND LSD1 REPRESS A MYELOID DIFFERENTIATION PROGRAM DURING INDUCED PLURIPOTENT STEM CELL DERIVED MEGAKARYOCYTE DIFFERENTIATION

, 2022
J. Venhuizen, M. van Bergen, D. Gilissen, Laura Wingens, Emile van den Akker, J. Jansen, Joost H.A. Martens, Bert van der Reijden   +7 more
openalex   +1 more source

Cellular analysis of the action of epigenetics drugs and probes [PDF]

, 2017
Small molecule drugs and probes are important tools in drug discovery, pharmacology, and cell biology. This is of course also true for epigenetic inhibitors.
A. Ganesan, Edwards AM, Fides Zenk, Gajer (née Wagner) J, Glaser KB, Glaser KB, Jung M, Lynch JT, Maeda T, Manfred Jung, Mirjam Hau, Nicola Iovino, van Lint C   +12 more
core   +1 more source

Lysine-Specific Demethylase 1 Has Dual Functions as a Major Regulator of Androgen Receptor Transcriptional Activity

Cell Reports, 2014
Summary: Lysine-Specific Demethylase 1 (LSD1, KDM1A) functions as a transcriptional corepressor through demethylation of histone 3 lysine 4 (H3K4) but has a coactivator function on some genes through mechanisms that are unclear.
Changmeng Cai, Housheng Hansen He, Shuai Gao, Sen Chen, Ziyang Yu, Yanfei Gao, Shaoyong Chen, Mei Wei Chen, Jesse Zhang, Musaddeque Ahmed, Yang Wang, Eric Metzger, Roland Schüle, X. Shirley Liu, Myles Brown, Steven P. Balk   +15 more
doaj   +1 more source

Phosphoproteomic analysis on ovarian follicles reveals the involvement of LSD1 phosphorylation in Chicken follicle selection [PDF]

, 2023
Yanhong Zhang, Qiuyue Chen, Yuanyuan Guo, Li Kang, Yi Sun, Yunliang Jiang   +5 more
openalex   +1 more source

Research progress of LSD1 in regulating tumor immune mechanisms [PDF]

Jichu yixue yu linchuang
Lysine-specific demethylase 1(LSD1) plays a regulatory role in tumor immunity. LSD1 affects CD8+T cell infiltration by regulating AGO2 protein level, and it is required for normal B cell proliferation and differentiation via reducing local chromatin ...
LONG Lijuan, SONG Songze, YE Qinong, LIN Jing
doaj   +1 more source

LSD1 is required for euchromatic origin firing and replication timing [PDF]

, 2022
Yue Wang, Yunchao Huang, Kwang‐Ting Cheng, Xinhua Liu, Yu Zhang, Jianguo Yang, Jordan T.F. Young, Grant W. Brown, Xiaohan Yang, Yongfeng Shang   +9 more
openalex   +1 more source

Cooperative role of LSD1 and CHD7 in regulating differentiation of mouse embryonic stem cells

Scientific Reports
Lysine-specific histone demethylase 1 (LSD1) is a histone demethylase that plays a critical role in epigenetic regulation by removing the methyl group from mono- and di-methylated lysine 4 on histone H3 (H3K4me1/2), acting as a repressor of gene ...
Sandhya Malla, Carlos Martinez-Gamero, Kanchan Kumari, Cyrinne Achour, Georgios Mermelekas, David Martinez-Delgado, Alba Coego, Diana Guallar, Angel-Carlos Roman, Francesca Aguilo   +9 more
doaj   +1 more source

LSD1 as a promising target for various diseases treatment through cell stemness regulation [PDF]

, 2022
Ting Ma, YinChao Li, Xiaoru Wang, Mengge Dai, Nan Wang, Meng Li, Shaotong Li   +6 more
openalex   +1 more source

Data from Novel Histone Demethylase LSD1 Inhibitors Selectively Target Cancer Cells with Pluripotent Stem Cell Properties

, 2023
Jing Wang, Fei Lu, Qi Ren, Hong Sun, Zhengshuang Xu, Rongfeng Lan, Yuqing Liu, David C. Ward, Junmin Quan, Ye Tao, Hui Zhang   +10 more
openalex   +1 more source