Results 11 to 20 of about 12,929 (212)
Strategies that regulate LSD1 for novel therapeutics
Acta Pharmaceutica Sinica BHistone methylation plays crucial roles in regulating chromatin structure and gene transcription in epigenetic modifications. Lysine-specific demethylase 1 (LSD1), the first identified histone demethylase, is universally overexpressed in various diseases.
Meng Li +7 more
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Science-Business eXchange, 2012 Two teams have independently provided preclinical proof of concept for using lysine-specific histone demethylase 1 inhibitors to treat acute myelogenous leukemia. One of the teams is now running a clinical trial of a generic monoamine oxidase inhibitor that counts the demethylase among its many targets, whereas at least four biotechs are advancing ...
Chris Cain
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Coaching LSD1 to ignore acetylation. [PDF]
Nat Chem BiolBlack JC, Kutateladze TG.
europepmc +3 more sources
Visualizing the Histone Code on LSD1 [PDF]
Cell, 2007 In this issue, Garcia-Bassets et al. (2007) show that spurious transcriptional activation by unliganded nuclear receptors is inhibited by histone lysine methylation. This inhibitory histone modification code is efficiently countered by the ligand-dependent recruitment of histone lysine demethylases, including lysine-specific demethylase 1 (LSD1), which
Matthew J. Gamble, W. Lee Kraus
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Demethylase-independent roles of LSD1 in regulating enhancers and cell fate transition
Nature Communications, 2023 The major enhancer regulator lysine-specific histone demethylase 1A (LSD1) is required for mammalian embryogenesis and is implicated in human congenital diseases and multiple types of cancer; however, the underlying mechanisms remain enigmatic.
Cheng Zeng +6 more
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LSD1 and the chemistry of histone demethylation [PDF]
Current Opinion in Chemical Biology, 2007 The recent discovery that histone demethylation can be catalyzed by the flavin-dependent amine oxidase LSD1 has ushered in a new chapter in the chromatin-remodeling community. Herein, we discuss the rapid progress of the histone demethylase field including the recent identification of the non-heme iron-dependent histone demethylases (JmjC family), the ...
Philip A. Cole, Jeffrey C. Culhane
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Over-expression of LSD1 promotes proliferation, migration and invasion in non-small cell lung cancer. [PDF]
PLoS ONE, 2012 BACKGROUND: Lysine specific demethylase 1 (LSD1) has been identified and biochemically characterized in epigenetics, but the pathological roles of its dysfunction in lung cancer remain to be elucidated.
Tangfeng Lv +6 more
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LSD1: Biologic Roles and Therapeutic Targeting [PDF]
Epigenomics, 2016 LSD1 (KDM1A; BHC110; AOF2) was the first protein reported to exhibit histone demethylase activity and has since been shown to have multiple essential roles in mammalian biology. Given its enzymatic activity and its high-level expression in many human malignancies, a significant recent focus has been the development of pharmacologic inhibitors.
Maiques-Diaz, Alba, Somervaille, Tim Cp
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LSD1 for the Targeted Regulation of Adipose Tissue
Current Issues in Molecular Biology, 2022 White and thermal (brown and beige) adipose tissue energy storage and oxidative regulation pathways play a central role in maintaining the energy balance throughout the body, and the dysregulation of these pathways is closely related to glucose and lipid metabolism disorders and adipose tissue dysfunction, including obesity, chronic inflammation ...
Li Chen +3 more
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Trends of LSD1 Inhibitors in Viral Infections [PDF]
Future Medicinal Chemistry, 2018 .
Zwergel, Clemens +3 more
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