Results 11 to 20 of about 27,519 (289)

TERRA-LSD1 phase separation promotes R-loop formation for telomere maintenance in ALT cancer cells

Nature Communications
The telomere repeat-containing RNA (TERRA) forms R-loops to promote homology-directed DNA synthesis in the alternative lengthening of telomere (ALT) pathway.
Meng Xu, Dulmi Senanayaka, Rongwei Zhao, Tafadzwa Chigumira, Astha Tripathi, Jason Tones, Rachel M. Lackner, Anne R. Wondisford, Laurel N. Moneysmith, Alexander Hirschi, Sara Craig, Sahar Alishiri, Roderick J. O’Sullivan, David M. Chenoweth, Nicholas J. Reiter, Huaiying Zhang   +15 more
doaj   +4 more sources

Discovery of an LSD1 PROTAC degrader. [PDF]

Proc Natl Acad Sci U S A
Significance The scaffolding role of lysine-specific demethylase 1 (LSD1), beyond its catalytic function, is critical in acute myeloid leukemia (AML) progression.
Hosseini A, Qiu X, Xiong Y, Chiang KHN, Catlett J, Kaltheuner I, Deng Z, Ghosh S, Shi Y, Jin J.   +9 more
europepmc   +4 more sources

Strategies that regulate LSD1 for novel therapeutics

Acta Pharmaceutica Sinica B
Histone methylation plays crucial roles in regulating chromatin structure and gene transcription in epigenetic modifications. Lysine-specific demethylase 1 (LSD1), the first identified histone demethylase, is universally overexpressed in various diseases.
Meng Li, Mengge Dai, Bing Cheng, Shaotong Li, Enhui Guo, Junwei Fu, Ting Ma, Bin Yu   +7 more
doaj   +4 more sources

LSD1 promotes prostate cancer reprogramming by repressing TP53 signaling independently of its demethylase function

JCI Insight, 2023
Lysine-specific demethylase 1 (LSD1) is a histone demethylase that promotes stemness and cell survival in cancers such as prostate cancer. Most prostate malignancies are adenocarcinomas with luminal differentiation.
Anbarasu Kumaraswamy, Zhi Duan, Diana Flores, Chao Zhang, Archana Sehrawat, Ya-Mei Hu, Olivia A. Swaim, Eva Rodansky, William K. Storck, Joshua A. Kuleape, Karan Bedi, Rahul Mannan, Xiao-Ming Wang, Aaron Udager, Visweswaran Ravikumar, Armand Bankhead III, Ilsa Coleman, John K. Lee, Colm Morrissey, Peter S. Nelson, Arul M. Chinnaiyan, Arvind Rao, Zheng Xia, Joel A. Yates, Joshi J. Alumkal   +24 more
doaj   +2 more sources

Demethylase-independent roles of LSD1 in regulating enhancers and cell fate transition

Nature Communications, 2023
The major enhancer regulator lysine-specific histone demethylase 1A (LSD1) is required for mammalian embryogenesis and is implicated in human congenital diseases and multiple types of cancer; however, the underlying mechanisms remain enigmatic.
Cheng Zeng, Jiwei Chen, Emmalee W. Cooke, Arijita Subuddhi, Eliana T. Roodman, Fei Xavier Chen, Kaixiang Cao   +6 more
doaj   +2 more sources

Caloric restriction leads to druggable LSD1-dependent cancer stem cells expansion [PDF]

Nature Communications
Caloric restriction (CR) has been demonstrated to have a role in tumour growth and therapy response but its effects on cancer stem cells are less known.
Rani Pallavi, Elena Gatti, Tiphanie Durfort, Massimo Stendardo, Roberto Ravasio, Tommaso Leonardi, Paolo Falvo, Bruno A. Duso, Simona Punzi, Aobuli Xieraili, Andrea Polazzi, Doriana Verrelli, Deborah Trastulli, Simona Ronzoni, Simone Frascolla, Giulia Perticari, Mohamed Elgendy, Mario Varasi, Emanuela Colombo, Marco Giorgio, Luisa Lanfrancone, Saverio Minucci, Luca Mazzarella, Pier Giuseppe Pelicci   +23 more
openalex   +2 more sources

The kinase NEK6 positively regulates LSD1 activity and accumulation in local chromatin sub-compartments

Communications Biology
LSD1 plays a crucial role in mammalian biology, regulated through interactions with coregulators and post-translational modifications. Here we show that the kinase NEK6 stimulates LSD1 activity in cells and observe a strong colocalization of NEK6 and ...
Franziska Knodel, Jürgen Eirich, Sabine Pinter, Stephan A. Eisler, Iris Finkemeier, Philipp Rathert   +5 more
doaj   +2 more sources

LSD1 deletion decreases exosomal PD-L1 and restores T-cell response in gastric cancer

Molecular Cancer, 2022
Background Histone lysine-specific demethylase 1 (LSD1) expression has been shown to be significantly elevated in gastric cancer (GC) and may be associated with the proliferation and metastasis of GC.
Dan-Dan Shen, Jing-Ru Pang, Ya-Ping Bi, Long-Fei Zhao, Yin-Rui Li, Li-Juan Zhao, Ya Gao, Bo Wang, Ning Wang, Liuya Wei, Huiqin Guo, Hong-Min Liu, Yi-Chao Zheng   +12 more
doaj   +2 more sources

LSD1 modulates the bone metastasis of breast cancer cells through hnRNPA2B1-mediated sorting of exosomal miRNAs

Cell Death Discovery
Bone metastasis is a key contributor to morbidity and mortality of breast cancer patients. We have previously shown that exosomal miRNAs derived from LSD1 knockdown (KD) breast cancer cells inhibit osteoblast differentiation and promote osteoclast ...
Ziyu Liu, Benkai Xin, Nan Zhang, Peipei An, Yueru Shi, Jingtong Yang, Youzhong Wan, Yuquan He, Xin Hu   +8 more
doaj   +2 more sources

LSD1/KDM1A inhibitors in clinical trials: advances and prospects [PDF]

Journal of Hematology & Oncology, 2019
Histone demethylase LSD1 plays key roles during carcinogenesis, targeting LSD1 is becoming an emerging option for the treatment of cancers. Numerous LSD1 inhibitors have been reported to date, some of them such as TCP, ORY-1001, GSK-2879552, IMG-7289 ...
Yuan Fang, Guochao Liao, Bin Yu
openalex   +2 more sources