Results 11 to 20 of about 24,350 (247)
Strategies that regulate LSD1 for novel therapeutics
Acta Pharmaceutica Sinica BHistone methylation plays crucial roles in regulating chromatin structure and gene transcription in epigenetic modifications. Lysine-specific demethylase 1 (LSD1), the first identified histone demethylase, is universally overexpressed in various diseases.
Meng Li +7 more
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Adolescent alcohol exposure alters lysine demethylase 1 (LSD1) expression and histone methylation in the amygdala during adulthood [PDF]
Biochemistry and Biophysics Reports, 2016 Small cell lung cancer (SCLC) is an aggressive neuroendocrine tumor characterized by rapid progression. The mechanisms that lead to a shift from initial therapeutic sensitivity to ultimate therapeutic resistance are poorly understood. Although the SCLC genomic landscape led to the discovery of promising agents targeting genetic alterations that were ...
Evan J. Kyzar +3 more
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LSD1: Biologic Roles and Therapeutic Targeting [PDF]
Epigenomics, 2016 LSD1 (KDM1A; BHC110; AOF2) was the first protein reported to exhibit histone demethylase activity and has since been shown to have multiple essential roles in mammalian biology. Given its enzymatic activity and its high-level expression in many human malignancies, a significant recent focus has been the development of pharmacologic inhibitors.
Maiques-Diaz, Alba, Somervaille, Tim Cp
openaire +3 more sources
Trends of LSD1 Inhibitors in Viral Infections [PDF]
Future Medicinal Chemistry, 2018 .
Clemens Zwergel +3 more
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Histone Demethylase LSD1 Regulates Adipogenesis [PDF]
Journal of Biological Chemistry, 2010 Epigenetic mechanisms, in particular the enzymatic modification of histones, are a crucial element of cell differentiation, a regulated process that allows a precursor cell basically to turn into a different cell type while maintaining the same genetic equipment.
Melina M, Musri +5 more
openaire +2 more sources
LSD1 Promotes Prostate Cancer Cell Survival by Destabilizing FBXW7 at Post-Translational Level
Frontiers in Oncology, 2021 Prostate cancer (PCa) is the most common cancer in men and the fifth leading cause of cancer death worldwide. Unfortunately, castration-resistant prostate cancer (CRPCa) is incurable with surgical treat and prone to drug resistance.
Xu-ke Qin +3 more
doaj +1 more source
Demethylase-independent roles of LSD1 in regulating enhancers and cell fate transition
Nature Communications, 2023 The major enhancer regulator lysine-specific histone demethylase 1A (LSD1) is required for mammalian embryogenesis and is implicated in human congenital diseases and multiple types of cancer; however, the underlying mechanisms remain enigmatic.
Cheng Zeng +6 more
doaj +1 more source
JCI Insight, 2023 Lysine-specific demethylase 1 (LSD1) is a histone demethylase that promotes stemness and cell survival in cancers such as prostate cancer. Most prostate malignancies are adenocarcinomas with luminal differentiation.
Anbarasu Kumaraswamy +24 more
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Alternative splicing of LSD1+8a in neuroendocrine prostate cancer is mediated by SRRM4
Neoplasia: An International Journal for Oncology Research, 2020 Neuroendocrine prostate cancer (NEPC) is the most virulent form of prostate cancer. Importantly, our recent work examining metastatic biopsy samples demonstrates NEPC is increasing in frequency.
Daniel J. Coleman +16 more
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Cell Reports, 2023 Summary: Targeting lysine-specific histone demethylase 1A (LSD1) can improve tumor immunogenicity of poorly immunogenic tumors, such as non-small cell lung cancer (NSCLC), with elevated T cell infiltration and sensitize tumors to anti-PD-1 therapy ...
Feiyu Tang +9 more
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