Results 81 to 90 of about 12,929 (212)

Management of T‐cell malignancies: Bench‐to‐bedside targeting of epigenetic biology

CA: A Cancer Journal for Clinicians, EarlyView.
Abstract The peripheral T‐cell lymphomas (PTCL) are the only disease for which four histone deacetylase (HDAC) inhibitors have been approved globally as single agents. Although it is not clear why the PTCL exhibit such a vulnerability to these drugs, understanding the biological basis for this activity is essential.
Ariana Sabzevari, Johnson Ung, Jeffrey W. Craig, Kallesh D. Jayappa, Ipsita Pal, David J. Feith, Thomas P. Loughran Jr, Owen A. O’Connor   +7 more
wiley   +1 more source

Lysine-Specific Histone Demethylase 1A Regulates Macrophage Polarization and Checkpoint Molecules in the Tumor Microenvironment of Triple-Negative Breast Cancer

Frontiers in Immunology, 2019
Macrophages play an important role in regulating the tumor microenvironment (TME). Here we show that classical (M1) macrophage polarization reduced expression of LSD1, nuclear REST corepressor 1 (CoREST), and the zinc finger protein SNAIL.
Abel H. Y. Tan, WenJuan Tu, Robert McCuaig, Kristine Hardy, Thomasina Donovan, Sofiya Tsimbalyuk, Jade K. Forwood, Sudha Rao   +7 more
doaj   +1 more source

Characteristic, Regulation and Targeting Strategies of Cancer Stem Cells and Their Niche in Digestive System Tumors

MedComm – Oncology, Volume 4, Issue 2, June 2025.
Cancer stem cells, characterized by self‐renewal, differentiation, heterogeneity, plasticity and tumorigenicity, are regulated by intrinsic factors such as signaling pathways, transcription factors, metabolism and noncoding RNAs, as well as environmental cells (including tumor cells, immune cells and stromal cells), environmental factors and distant ...
Zhenzhen Chen, Huanle Qi, Yapeng Xue, Yaqi Zhang, Zhuo Zhang, Shun Xu, Shixin Liao, Xiaoyu Zeng, Jiayi Wu, Xinrui Lv, Qiankun He, Pingping Zhu   +11 more
wiley   +1 more source

Nitrocyclopropanes as Valuable Building Blocks in Organic Synthesis and Biology: Exploring the Origin of the Nitro Group

Chemistry – A European Journal, Volume 31, Issue 20, April 4, 2025.
This review summarizes the synthetic methodologies of the nitro‐substituted Donor‐Acceptor cyclopropanes (NCPs). Particularly from nitroalkenes including the Michael Initiated Ring Closure and the Oxidative Ring Closure of Michael Adducts, from Diazo Compounds bearing Nitro Group, from Nitromethane and its Derivatives; and after Oxidation of ...
Andriani G. Chaidali, Michael A. Terzidis, Ioannis N. Lykakis   +2 more
wiley   +1 more source

Characterization of LSD1 Expression Within the Murine Eye

Investigative Opthalmology & Visual Science, 2019
The purpose of this study was to extend the current understanding of endogenous lysine-specific demethylase 1 (LSD1) expression spatially and temporally in the retina. Toward that end, we determined the localization and levels of LSD1 and its substrates H3K4me1 and H3K4me2 (H3K4me1/2) within the murine eye.Immunofluorescent microscopy for LSD1, H3K4me1,
Jeffrey H Boatright, Jeffrey H Boatright, Hans E. Grossniklaus, John M. Nickerson, Salma Ferdous   +4 more
openaire   +3 more sources

LSD1 Promotes Bladder Cancer Progression by Upregulating LEF1 and Enhancing EMT

Frontiers in Oncology, 2020
Epithelial-to-mesenchymal transition (EMT) is one of the important underlying molecular mechanisms for most types of cancers including bladder cancer.
Qiubo Xie, Tang Tang, Jian Pang, Jing Xu, Xingxia Yang, Linang Wang, Yiqiang Huang, Zhuowei Huang, Gaolei Liu, Dali Tong, Yao Zhang, Luofu Wang, Dianzheng Zhang, Weihua Lan, Qiuli Liu, Jun Jiang   +15 more
doaj   +1 more source

FOXK1 promotes hormonally responsive breast carcinogenesis by suppressing apoptosis

Animal Models and Experimental Medicine, Volume 8, Issue 4, Page 638-648, April 2025.
Our findings suggest that FOXK1 promotes breast carcinogenesis by inhibiting cell apoptosis. We explore the clinical significance of FOXK1/REST/CoREST‐ BCL2L11/BBC3 axis in breast carcinomas. Abstract Background Globally, breast cancer constitutes the predominant malignancy in women.
Minghui Zhao, Tingyao Ma, Zhaohan Zhang, Yu Wang, Xilin Wang, Wenjuan Wang, Xiaohong Chen, Ran Gao, Lin Shan   +8 more
wiley   +1 more source

LSD1 inhibition suppresses the growth of clear cell renal cell carcinoma via upregulating P21 signaling

Acta Pharmaceutica Sinica B, 2019
Histone lysine-specific demethylase 1 (LSD1) has been implicated in the disease progression of several types of solid tumors. This study provides the first evidence showing that LSD1 overexpression occurred in 62.6% (224/358) of clear cell renal cell ...
Liangsong Zhu, Jianfeng Wang, Wen Kong, Jiwei Huang, Baijun Dong, Yiran Huang, Wei Xue, Jin Zhang   +7 more
doaj  

Silencing Lysine-Specific Histone Demethylase 1 (LSD1) Causes Increased HP1-Positive Chromatin, Stimulation of DNA Repair Processes, and Dysregulation of Proliferation by Chk1 Phosphorylation in Human Endothelial Cells

Cells, 2019
The methylation of histone lysine residues modifies chromatin conformation and regulates the expression of genes implicated in cell metabolism. Lysine-specific demethylase 1 (LSD1) is a flavin-dependent monoamine oxidase that can demethylate mono- and ...
Martyna Wojtala, Arkadiusz Dąbek, Dorota Rybaczek, Agnieszka Śliwińska, Ewa Świderska, Katarzyna Słapek, Assam El-Osta, Aneta Balcerczyk   +7 more
doaj   +1 more source

Posttranslational Modification in Bone Homeostasis and Osteoporosis

MedComm, Volume 6, Issue 4, April 2025.
This review summarizes the updating researches concerning bone formation and bone resorption mediated by different types of posttranslational modification. We highlight dysregulated posttranslational modification in osteoblast and osteoclast differentiation. We then emphasize involvement of posttranslational modification in osteoporosis development, so
Yuzhe Lin, Shide Jiang, Yuming Yao, Hengzhen Li, Hongfu Jin, Guang Yang, Bingzhou Ji, Yusheng Li   +7 more
wiley   +1 more source