Results 81 to 90 of about 11,397 (98)

Effect of a Novel Antidepressant and Anticancer Nuc01 on Depression in Cancer Survivors. [PDF]

Curr Issues Mol Biol
Yuan C, Shi X, Wang Z, Li Y, Ma W, Fu K.
europepmc   +1 more source

Effect of harvest on the agronomic, mineral and antioxidant profile of three oregano species (<i>Origanum onites</i> L., <i>Origanum vulgare</i> L. ssp. <i>hirtum</i>, and <i>Origanum acutidens</i> (Hand.-Mazz.) Ietswaart). [PDF]

PeerJ
Uskutoğlu T.
europepmc   +1 more source

Dual targeting of CDK6 and LSD1 is synergistic and overcomes differentiation blockade in AML. [PDF]

EMBO Mol Med
Brault L, Voisset E, Desaunay M, Boudet A, Kousteridou P, Letard S, Carbuccia N, Goubard A, Castellano R, Collette Y, Vernerey J, Vigon I, Pasquet JM, Dubreuil P, Lopez S, De Sepulveda P.   +15 more
europepmc   +1 more source

The Artemisia argyi oil reduces high-fat diet-induced obesity by enhancing thermogenesis in brown adipose tissue. [PDF]

NPJ Sci Food
Wang S, Lin S, Xie F, Liu S, He T, Chen K, Huang Z, Xie W, Cheng H, Zhang J, Li W.   +10 more
europepmc   +1 more source

RCOR1 promotes myoblast differentiation and muscle regeneration. [PDF]

Cell Death Discov
Pauk M, Wang F, Rummukainen P, Ramm HGM, Taipaleenmäki H, Kiviranta R.   +5 more
europepmc   +1 more source

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Modeling LSD1-Mediated Tumor Stagnation

Bulletin of Mathematical Biology, 2021
LSD1 (KDMA1) has gained attention in the last decade as a cancer biomarker and drug target. In particular, recent work suggests that LSD1 inhibition alone reduces tumor growth, increases T cell tumor infiltration, and complements PD1/PDL1 checkpoint inhibitor therapy.
Jesse Milzman, Wanqiang Sheng, Doron Levy   +2 more
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Reversible Lysine Specific Demethylase 1 (LSD1) Inhibitors: A Promising Wrench to Impair LSD1

Journal of Medicinal Chemistry, 2021
As a flavin adenine dinucleotide (FAD)-dependent monoamine oxidase, lysine specific demethylase 1 (LSD1/KDM1A) functions as a transcription coactivator or corepressor to regulate the methylation of histone 3 lysine 4 and 9 (H3K4/9), and it has emerged as a promising epigenetic target for anticancer treatment. To date, numerous inhibitors targeting LSD1
Xing-Jie Dai, Ying Liu, Lei-Peng Xue, Xiao-Peng Xiong, Ying Zhou, Yi-Chao Zheng, Hong-Min Liu   +6 more
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Discovery of acridine-based LSD1 inhibitors as immune activators targeting LSD1 in gastric cancer

European Journal of Medicinal Chemistry, 2023
LSD1 is overexpressed in various cancers and promotes tumor cell proliferation, tumor expansion, and suppresses immune cells infiltration and is closely associated with immune checkpoint inhibitors therapy. Therefore, the inhibition of LSD1 has been recognized as a promising strategy for cancer therapy.
Hui-Min Liu, Xiao-Peng Xiong, Jiang-Wan Wu, He-Xiang Chen, Ying Zhou, Shi-Kun Ji, Xing-Jie Dai, Yi-Chao Zheng, Hong-Min Liu   +8 more
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LSD1 Makes Fat Colorful

Trends in Endocrinology & Metabolism, 2017
The histone lysine-specific demethylase 1 (LSD1) is a new and important player in the regulation of brown fat identity and function. In a recent Cell Reports article, Duteil et al. show that LSD1 exerts its effects via regulation of specific histone marks as well as through association with co-repressor complexes.
Leon G, Straub, Christian, Wolfrum
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A comprehensive comparative study on LSD1 in different cancers and tumor specific LSD1 inhibitors

European Journal of Medicinal Chemistry, 2022
LSD1 was significantly over-expressed in several cancer types, and its aberrant overexpression was revealed to play a crucial role in the initiation and progression of cancer. Several LSD1 inhibitors that were discovered and developed so far were found to be effective in attenuating tumor growth in both in vivo and in vitro studies.
Jianshu Dong, Waqar Pervaiz, Bilal Tayyab, Dié Li, Lei Kang, Huimin Zhang, Huimin Gong, Xinli Ma, Jian Li, Clement Agboyibor, Yuefeng Bi, Hongmin Liu   +11 more
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