Results 81 to 90 of about 24,350 (247)

Biogenic retrograde signaling via GUN1 ensures thermotolerant chloroplast biogenesis during seedling establishment in Arabidopsis thaliana

Journal of Integrative Plant Biology, EarlyView.
Under heat stress, GENOMES UNCOUPLED1 (GUN1) is crucial for the formation of functional chloroplasts in seedlings under heat stress. Without GUN1, chloroplast development fails and seedlings fail to turn green. Therefore, GUN1 helps relay heat‐related cues to maintain chloroplast biogenesis and support thermotolerance during early growth.
Shan Qi, Chaojun Cui, Jieya Xia, Mengping Li, Mengshuang Li, Jong‐Seong Jeon, Chanhong Kim   +6 more
wiley   +1 more source

The deubiquitinase USP38 affects cellular functions through interacting with LSD1

Biological Research, 2018
Background Deubiquitination is a posttranslational protein modification prevalent in mammalian cells. Deubiquitinases regulate the functions of the target protein by removing its ubiquitin chain.
Wenbin Liu, Qi Zhang, Yuanyuan Fang, Yanan Wang   +3 more
doaj   +1 more source

LSD1 deletion decreases exosomal PD-L1 and restores T-cell response in gastric cancer

Molecular Cancer, 2022
Background Histone lysine-specific demethylase 1 (LSD1) expression has been shown to be significantly elevated in gastric cancer (GC) and may be associated with the proliferation and metastasis of GC.
Dan-Dan Shen, Jing-Ru Pang, Ya-Ping Bi, Long-Fei Zhao, Yin-Rui Li, Li-Juan Zhao, Ya Gao, Bo Wang, Ning Wang, Liuya Wei, Huiqin Guo, Hong-Min Liu, Yi-Chao Zheng   +12 more
doaj   +1 more source

Epigenomics‐guided precision oncology: Chromatin variants in prostate tumor evolution

International Journal of Cancer, Volume 158, Issue 2, Page 314-332, 15 January 2026.
Abstract Prostate cancer is a common malignancy that in 5%–30% leads to treatment‐resistant and highly aggressive disease. Metastasis‐potential and treatment‐resistance is thought to rely on increased plasticity of the cancer cells—a mechanism whereby cancer cells alter their identity to adapt to changing environments or therapeutic pressures to create
Kira Furlano, Tina Keshavarzian, Nadine Biernath, Annika Fendler, Maria de Santis, Joachim Weischenfeldt, Mathieu Lupien   +6 more
wiley   +1 more source

Epigenetic repression of Cend1 by lysine-specific demethylase 1 is essential for murine heart development

iScience
Summary: Epigenetic regulation of heart development remains incompletely understood. Here we show that LSD1, a histone demethylase, plays a crucial role in regulating cardiomyocyte proliferation during heart development.
Huahua Liu, Rui Zhou, Shanshan Li, Jinling Dong, Yuan Fang, Yuru Luo, Hongyu Su, Baochang Lai, Lingli Liang, Donghong Zhang, Yanmin Zhang, John Y-J. Shyy, Bin Zhou, Zuyi Yuan, Yidong Wang   +14 more
doaj   +1 more source

Silencing Lysine-Specific Histone Demethylase 1 (LSD1) Causes Increased HP1-Positive Chromatin, Stimulation of DNA Repair Processes, and Dysregulation of Proliferation by Chk1 Phosphorylation in Human Endothelial Cells

Cells, 2019
The methylation of histone lysine residues modifies chromatin conformation and regulates the expression of genes implicated in cell metabolism. Lysine-specific demethylase 1 (LSD1) is a flavin-dependent monoamine oxidase that can demethylate mono- and ...
Martyna Wojtala, Arkadiusz Dąbek, Dorota Rybaczek, Agnieszka Śliwińska, Ewa Świderska, Katarzyna Słapek, Assam El-Osta, Aneta Balcerczyk   +7 more
doaj   +1 more source

Epigenomic Regulation of Androgen Receptor Signaling: Potential Role in Prostate Cancer Therapy. [PDF]

, 2017
Androgen receptor (AR) signaling remains the major oncogenic pathway in prostate cancer (PCa). Androgen-deprivation therapy (ADT) is the principle treatment for locally advanced and metastatic disease.
Cucchiara, Vito, Evans, Christopher P, Gao, Allen C, Mirone, Vincenzo, Rosenfeld, Michael G, Yang, Joy C   +5 more
core   +2 more sources

Human Histone Demethylase LSD1 Reads the Histone Code [PDF]

Journal of Biological Chemistry, 2005
Human histone demethylase LSD1 is a flavin-dependent amine oxidase that catalyzes the specific removal of methyl groups from mono- and dimethylated Lys4 of histone H3. The N-terminal tail of H3 is subject to various covalent modifications, and a fundamental question in LSD1 biology is how these epigenetic marks affect the demethylase activity.
F. Forneris, C. Binda, M.A. Vanoni, E. Battaglioli, A. Mattevi   +4 more
openaire   +4 more sources

Therapeutic targeting of chromatin alterations in leukemia and solid tumors

International Journal of Cancer, Volume 158, Issue 2, Page 382-408, 15 January 2026.
Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner, Tobias Berg, Daniel Sasca, Sophie‐Luise Mersiowsky, Jayant Y. Gadrey, Johanna Thomas, Michael W. M. Kühn, Michael Lübbert   +7 more
wiley   +1 more source

Lsd1 restricts the number of germline stem cells by regulating multiple targets in escort cells. [PDF]

PLoS Genetics, 2014
Specialized microenvironments called niches regulate tissue homeostasis by controlling the balance between stem cell self-renewal and the differentiation of stem cell daughters.
Susan Eliazer, Victor Palacios, Zhaohui Wang, Rahul K Kollipara, Ralf Kittler, Michael Buszczak   +5 more
doaj   +1 more source