Results 71 to 80 of about 14,132 (212)

Redefining Therapies for Drug‐Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design

Advanced Healthcare Materials, Volume 15, Issue 14, 10 April 2026.
Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Aline Martins dos Santos, Jonatas Lobato Duarte, Letícia Oliveira Catarin Nunes, Túlio Custódio Reis, Lara Cerazi Salvador, Norival Alves Santos‐Filho, Rafael Miguel Sábio, Hélder A. Santos, Fernando Rogério Pavan   +11 more
wiley   +1 more source

Implementation of latent tuberculosis infection screening and treatment among newly arriving immigrants in the Netherlands: A mixed methods pilot evaluation.

PLoS ONE, 2019
IntroductionTo reach pre-elimination levels of tuberculosis (TB) incidence in the Netherlands, prevention of TB among immigrants through diagnosis and treatment of latent TB infection (LTBI) is needed.
Ineke Spruijt, Connie Erkens, Jeanine Suurmond, Erik Huisman, Marga Koenders, Peter Kouw, Sophie Toumanian, Frank Cobelens, Susan van den Hof   +8 more
doaj   +1 more source

The Global Burden of Latent Tuberculosis Infection: A Re-estimation Using Mathematical Modelling

PLoS Medicine, 2016
Background The existing estimate of the global burden of latent TB infection (LTBI) as “one-third” of the world population is nearly 20 y old. Given the importance of controlling LTBI as part of the End TB Strategy for eliminating TB by 2050, changes in ...
R. Houben, P. Dodd
semanticscholar   +1 more source

A Deep Representation Learning Method for Quantitative Immune Defense Function Evaluation and Its Clinical Applications

Advanced Science, Volume 13, Issue 17, 23 March 2026.
ImmuDef, a novel algorithm to quantitatively evaluate the anti‐infection immune defense function of an individual based on RNA‐seq data via a variational autoencoder (VAE) model. It is validated on 3200+ samples across four immune states with high accuracy. It can serve as a metric for disease severity and prognosis across pathogenic cohorts.
Zhen‐Lin Tan, Tao Luo, Yu Lin, Xiao‐Jun Wu, Wen‐Kang Shen, Jie Chen, Qian Lei, An‐Yuan Guo   +7 more
wiley   +1 more source

D‐Dimer: A Mediator of the Association Between Lymphocyte and Dissemination of Pulmonary Tuberculosis: A Retrospective Cohort Study

The Clinical Respiratory Journal, Volume 20, Issue 3, March 2026.
This study identifies D‐dimer as a key mediator between lymphocyte depletion and pulmonary tuberculosis dissemination. Our findings reveal that reduced lymphocyte counts increase dissemination risk partly by elevating D‐dimer levels, suggesting a critical link between immune deficiency and coagulopathy.
Yujun Lin, Di Wu, Xiaohong Chen, Lujing Jiang, Yiming Zeng   +4 more
wiley   +1 more source

Comparison of Rifampin and Isoniazid for Latent Tuberculosis Infection in Kidney Transplant Candidates: Focus on Tolerability and Treatment Completion

Transplant Infectious Disease, Volume 28, Issue 2, March/April 2026.
This study comparing 4‐month rifampin with 9‐month isoniazid for latent tuberculosis in kidney transplant candidates showed higher treatment completion rates and no transaminase elevations in the rifampin group. However, some patients experienced an increase in blood pressure while taking antihypertensive medications known to interact with rifampin ...
Jacques Simkins, Julia Bini Viotti, Yoichiro Natori, Shweta Anjan, Adela Mattiazzi, Mariella Ortigosa‐Goggins, Giselle Guerra, David Roth, Warren Kupin, Javier A. Pagan, Franco Cabeza, Gaetano Ciancio, Mahmoud Morsi, Michele I. Morris   +13 more
wiley   +1 more source

Impaired Mycobacterium tuberculosis-specific T-cell memory phenotypes and functional profiles among adults with type 2 diabetes mellitus in Uganda

Frontiers in Immunology
BackgroundEfforts to eradicate tuberculosis (TB) are threatened by diabetes mellitus (DM), which confers a 3-fold increase in the risk of TB disease.
Phillip Ssekamatte, Phillip Ssekamatte, Rose Nabatanzi, Diana Sitenda, Marjorie Nakibuule, Bernard Ssentalo Bagaya, Davis Kibirige, Andrew Peter Kyazze, David Patrick Kateete, Obondo James Sande, Reinout van Crevel, Stephen Cose, Irene Andia Biraro, Irene Andia Biraro   +13 more
doaj   +1 more source

Towards tuberculosis elimination: an action framework for low-incidence countries

European Respiratory Journal, 2015
This paper describes an action framework for countries with low tuberculosis (TB) incidence (
K. Lönnroth, G. Migliori, I. Abubakar, L. D’Ambrosio, G. de Vries, R. Diel, P. Douglas, D. Falzon, Marc-André Gaudreau, D. Goletti, E. González Ochoa, P. Lobue, A. Matteelli, H. Njoo, I. Solovič, A. Story, Tamara Tayeb, M. J. van der Werf, D. Weil, J. Zellweger, M. Abdel Aziz, Mohamed Al Lawati, S. Aliberti, Wouter Arrazola de Oñate, D. Barreira, V. Bhatia, F. Blasi, A. Bloom, J. Bruchfeld, F. Castelli, R. Centis, D. Chemtob, D. Cirillo, A. Colorado, A. Dadu, U. Dahle, L. De Paoli, H. M. Dias, R. Duarte, L. Fattorini, M. Gaga, H. Getahun, P. Glaziou, L. Goguadze, M. del Granado, W. Haas, A. Järvinen, G. Kwon, D. Mosca, P. Nahid, N. Nishikiori, I. Noguer, J. O’Donnell, A. Pace-Asciak, M. G. Pompa, G. Popescu, C. Robalo Cordeiro, K. Rønning, M. Ruhwald, J. Sculier, A. Šimunović, A. Smith-Palmer, G. Sotgiu, G. Sulis, C. Torres-Duque, Kazunori Umeki, M. Uplekar, C. van Weezenbeek, Tuula Vasankari, R. Vitillo, C. Voniatis, M. Wanlin, M. Raviglione   +72 more
semanticscholar   +1 more source

Recent Advances in Quantum Dots‐Based Sensors for the Detection of Tuberculosis: A Review

ChemistrySelect, Volume 11, Issue 6, 12 February 2026.
Quantum dot‐based biosensors enable rapid, sensitive detection of tuberculosis by converting biomolecular interactions into fluorescent signals. Target‐specific probes recognize TB biomarkers, producing measurable optical responses. This platform offers high sensitivity, multiplexing capability, and portability, supporting early diagnosis and improved ...
Alungile Mtotywa, Siyasanga Booysen, Mduduzi P. Radebe, Fredrick O. Okumu, Bernard O. Owaga, Martin O. Onani   +5 more
wiley   +1 more source

Latent tuberculosis infection and infection-associated risk factors for miner workers with silicosis in eastern China

BMC Pulmonary Medicine
Objectives Silicosis people are at high risk of developing pulmonary tuberculosis. Whether silica exposure increases the likelihood of latent tuberculosis infection (LTBI) was not well understood, and potential factors involved in LTBI risk among ...
Xinsong Hu, Cheng Chen, Qianqian Gao, Lang Zhou, Yan Shao, Guoli Li, Honghuan Song, Qiao Liu, Lei Han, Limei Zhu   +9 more
doaj   +1 more source