Results 81 to 90 of about 16,606 (224)

Latent TB Infection (LTBI) – Mycobacterium tuberculosis pathogenesis and the dynamics of the granuloma battleground [PDF]

International Journal of Infectious Diseases, 2019
Latent tuberculosis infection (LTBI) is established in over 90% of persons infected with Mycobacterium tuberculosis (Mtb), from whom new active TB cases will arise. Understanding the spatio-temporal dynamics of host immune responses in LTBI granulomas is essential to designing effective post-exposure therapies that inhibit progression to TB ...
Martin Rao, Giuseppe Ippolito, Sayoki Mfinanga, Francine Ntoumi, Dorothy Yeboah-Manu, Cristina Vilaplana, Alimuddin Zumla, Markus Maeurer   +7 more
openaire   +7 more sources

Clinical application of single‐cell RNA sequencing in disease and therapy

Clinical and Translational Medicine, Volume 15, Issue 11, November 2025.
This review provides a comprehensive overview of the application of scRNA‐seq in revisiting the somatic cell evolutions in human diseases, as well as in biomarker discovery and drug development. Abstract Background The emergence of single‐cell RNA sequencing (scRNA‐seq) technology has revolutionized our capacity to study cell functions in complex ...
Aisha Shigna Nadukkandy, Sowmiya Kalaiselvan, Lin Lin, Yonglun Luo   +3 more
wiley   +1 more source

Performance of QuantiFERON-TB Gold In-Tube (QFTGIT) for the diagnosis of Mycobacterium tuberculosis (Mtb) infection in Afar Pastoralists, Ethiopia [PDF]

, 2010
Background Currently, T-cell based gamma interferon (IFNγ) release assays (IGRAs) are acknowledged as the best methods available for the screening of latent tuberculosis infection (LTBI) and also as aid for the diagnosis of active ...
Mengistu Legesse, Gobena Ameni, Gezahegne Mamo, Girmay Medhin, Gunnar Bjune, Fekadu Abebe   +5 more
core   +1 more source

Cytomegalovirus Infection After Chimeric Antigen Receptor T‐Cell Therapy or Bispecific Antibody Treatment for Hematologic Malignancies

Transplant Infectious Disease, Volume 27, Issue 6, November/December 2025.
This retrospective study analyzed the incidence of CMV infections among 179 patients who received CAR T‐cell or BsAb therapy for hematologic malignancies. CMV infections occurred in 43% in CAR T‐cell and 62% in BsAb recipients, with 1–4% progressing to CMV diseases.
Juhui Han, So Yun Lim, Jaewon Hyung, Hyungwoo Cho, Dok Hyun Yoon, Sung‐Han Kim   +5 more
wiley   +1 more source

Risk Factors of Progression to Active Tuberculosis in Rheumatic Patients With Latent Tuberculosis: A Retrospective Study

Immunity, Inflammation and Disease, Volume 13, Issue 10, October 2025.
ABSTRACT Background In rheumatism patients, the immune system erroneously attacks the body′s own tissues. This impairs the body′s defense against external pathogens and is a contributing factor to the occurrence of tuberculosis infection. The primary objective of this investigation was to examine the risk factors for the progression from latent ...
Fengjuan Wang, Lei Zhou, Xiaoyan Hao, Jiayun Liu   +3 more
wiley   +1 more source

Implementation of latent tuberculosis infection screening and treatment among newly arriving immigrants in the Netherlands: A mixed methods pilot evaluation.

PLoS ONE, 2019
IntroductionTo reach pre-elimination levels of tuberculosis (TB) incidence in the Netherlands, prevention of TB among immigrants through diagnosis and treatment of latent TB infection (LTBI) is needed.
Ineke Spruijt, Connie Erkens, Jeanine Suurmond, Erik Huisman, Marga Koenders, Peter Kouw, Sophie Toumanian, Frank Cobelens, Susan van den Hof   +8 more
doaj   +1 more source

A Case of Advanced Urothelial Carcinoma Requiring Treatment Following a Positive Interferon‐Gamma Release Assay Prior to Avelumab Administration

IJU Case Reports, Volume 8, Issue 5, Page 454-457, September 2025.
ABSTRACT Introduction The association between the risk of latent tuberculosis infection (LTBI) reactivation and immune checkpoint inhibitor (ICI) administration has been reported. Case Presentation A man in his seventies underwent robot‐assisted laparoscopic radical cystectomy with ileal conduit diversion for muscle‐invasive bladder cancer. Three years
Yukiya Odagiri, Yoshiki Hiyama, Umi Ishida, Naotaka Nishiyama, Yoshihiro Yamamoto, Hiroshi Kitamura   +5 more
wiley   +1 more source

Impaired Mycobacterium tuberculosis-specific T-cell memory phenotypes and functional profiles among adults with type 2 diabetes mellitus in Uganda

Frontiers in Immunology
BackgroundEfforts to eradicate tuberculosis (TB) are threatened by diabetes mellitus (DM), which confers a 3-fold increase in the risk of TB disease.
Phillip Ssekamatte, Phillip Ssekamatte, Rose Nabatanzi, Diana Sitenda, Marjorie Nakibuule, Bernard Ssentalo Bagaya, Davis Kibirige, Andrew Peter Kyazze, David Patrick Kateete, Obondo James Sande, Reinout van Crevel, Stephen Cose, Irene Andia Biraro, Irene Andia Biraro   +13 more
doaj   +1 more source

QuantiFERON-TB gold in-tube implementation for latent tuberculosis diagnosis in a public health clinic: a cost-effectiveness analysis [PDF]

, 2012
BACKGROUND: The tuberculin skin test (TST) has limitations for latent tuberculosis infection (LTBI) diagnosis in low-prevalence settings. Previously, all TST-positive individuals referred from the community to Baltimore City Health Department (BCHD) were
Danielle DiPietro, Howard Choi, Kathryn Miele, Maria Martins-Evora, Maunank Shah, Susan Dorman, Vincent Marsiglia   +6 more
core   +1 more source

Network Pharmacology and Molecular Docking Study of Sanhuang Xiexin Decoction Against Tuberculosis

ChemistrySelect, Volume 10, Issue 35, September 16, 2025.
SHXXD’s 47 compounds and TB transcriptomics to hub genes TNF/IFNG/CASP3, validating potent docking scores and positioning the formula as a network‐based weapon against drug‐resistant tuberculosis. Abstract Tuberculosis (TB) remains a significant global health issue.
Feng Xu, Bo Chen, Chen Wang, Liu‐Cheng Li, Xiao‐Qin Wang, Kai‐Li Mao, Qiu Jiang   +6 more
wiley   +1 more source