Results 181 to 190 of about 45,597 (264)

Fluorescent cAMP Analogs: Enzymatic Synthesis, Unexpected Photophysical Behavior and Protein Kinase A Recognition

Angewandte Chemie, Volume 138, Issue 41, 5 October 2026.
Cyclic adenosine monophosphate (cAMP) is a key cellular second messenger. Adenylyl cyclase converts emissive isomorphic nucleoside triphosphates into fluorescent cAMPs. cthAMP displays unusually high brightness compared to thATP, its precursor, enabling real‐time monitoring of enzymatic reactions.
Deyuan Cong, Victor Dubois, Jamie Y. Lam, Yitzhak Tor   +3 more
wiley   +2 more sources

RNA methyltransferase 3 drives pancreatic acinar cell carcinoma growth and is a therapeutic target. [PDF]

Signal Transduct Target Ther
Tatekawa S, Hara T, Meng S, Sato T, Arai T, Tamari K, Arao Y, Tsuji Y, Konno M, Ofusa K, Kitamura K, Rennie S, Inui M, Taguchi D, Akita H, Motooka D, Murakumo Y, Inohara H, Doki Y, Eguchi H, Ogawa K, Ishii H.   +21 more
europepmc   +1 more source

Methionine Regulates Antitumour Function of CD8+ T Cells Through Polyamine Synthesis

Immunology, Volume 179, Issue 3, Page 418-433, November 2026.
Methionine restriction in vitro enhances CD8+ T cell effector function by suppressing polyamine synthesis and progressively induces the co‐expression of PD‐1 and TIM‐3. Consistently, sustained dietary methionine restriction diminishes the efficacy of adoptive T cell therapy (ACT) and promotes the expression of terminal exhaustion‐associated markers ...
Tian Zhao, Gillian A. Carleton, Sam Preshaw, Sarah MacPherson, Madison Shiyuk, Joseph Monaghan, Jun Han, Oro Uchenunu, Robert Rottapel, Ralph J. DeBerardinis, Kelly M. Stewart, Bo‐Hyun Kim, Juan Ausió, David R. Goodlett, Helena Pětrošová, Kyle D. Duncan, Julian J. Lum   +16 more
wiley   +1 more source

A Color-Tuning Bioluminescent Sensor (AmyLuc) for Real-Time Monitoring of Intracellular pH Dynamics in Cancer Cells. [PDF]

Anal Chem
Bevilaqua VR, Punzo A, Silla A, Duek EAR, Roda A, Viviani VR, Caliceti C.   +6 more
europepmc   +1 more source

Synthesis, Antiparasitic Activity, and ADME Profile of Morpholinephenylbenzamides: A Pharmacological Study Against Chagas Disease and Visceral Leishmaniasis

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
Hit‐to‐lead optimization of morpholinephenylbenzamides reveals key structure–activity relationships against Trypanosoma cruzi and Leishmania infantum. Potency, selectivity, and ADME properties are differentially improved across the series, identifying compounds 20, 24, and 16 as complementary templates for the future design of dual antiparasitic leads.
Danilo Nascimento Farago, Daniela de Melo Resende, Mariza Gabriela Faleiro de Moura Lodi Cruz, Rafaela Marçal Sousa, Rafael Consolin Chelucci, Simone Michelan‐Duarte, Felipe da Silva Mendonça de Melo, Douglas Davison da Silva Oliveira, Paula Derksen Macruz, Alexandra Maria dos Santos Carvalho, Eduardo Jorge Pilau, Izabela Marques Dourado Bastos, Adriano D. Andricopulo, Leonardo L. G. Ferreira, Silvane Maria Fonseca Murta, Celso de Oliveira Rezende Júnior   +15 more
wiley   +1 more source

Temperature signals drive grass secondary cell wall thickening. [PDF]

Curr Biol
Gregory GA, Khahani B, Coomey JH, Gonze D, Omran S, McGillivray KA, Campana KR, Stewart CE, Gardner KA, Follette D, Hazen SP.   +10 more
europepmc   +1 more source

Continuous Hypermutation and Evolution of Luciferase Variants. [PDF]

ACS Chem Biol
Hadjian T, Deshpande RA, Torrey ZR, Hammond AW, Molina RS, Ng K, Liu CC, Prescher JA.   +7 more
europepmc   +1 more source

Autonomous Bioluminescence Systems: From Molecular Mechanisms to Emerging Applications. [PDF]

JACS Au
Kusuma SH, Hattori M, Nagai T.
europepmc   +1 more source

TET1 Inhibition Promotes Therapeutic Sensitivity in TP53‐Mutant GBM by Influencing Genome Fragility and Altering TAMs Biology

Advanced Science, Volume 13, Issue 55, 5 October 2026.
In TP53mut GBM cells, reduced P53 function is associated with increased TET1 expression. Genetic or pharmacological inhibition of TET1 correlates with genome fragility, including DNA damage, cellular senescence, telomere shortening, and reactive oxygen species accumulation, which may contribute to increased efficacy of antitumor therapy.
Zhuonan Pu, Jinqiu Liu, Yuxuan Deng, Shuyu Hao, Xiaoli Zhang, Mingxu Yang, Chao Guo, Chao Du, Yingdan Chen, Tai Sun, Nan Ji, Zhengping Zhuang, Jie Feng   +12 more
wiley   +1 more source

Development of an <i>in vivo</i>, screenable, split-luciferase based model of huntingtin multimerization. [PDF]

iScience
Thomas MG, Levy SA, Jenkins MH, Lambert M, Frost B.   +4 more
europepmc   +1 more source