Results 51 to 60 of about 504,468 (237)

Herb Formula “Fufangqishe-Pill” Prevents Upright Posture–Induced Intervertebral Disc Degeneration at the Lumbar in Rats

Journal of Pharmacological Sciences, 2010
Degeneration of the lumbar spine plays an important role in most chronic low back pain. Prevention of lumbar intervertebral disc (IVD) degeneration is therefore a high research priority.
Qian-Qian Liang, Zhi-Jie Xi, Qin Bian, Xue-Jun Cui, Chen-Guang Li, Wei Hou, Qi Shi, Yong-Jun Wang   +7 more
doaj   +1 more source

Early disc degeneration in radiotherapy-treated childhood brain tumor survivors

BMC Musculoskeletal Disorders, 2023
Background Childhood brain tumor (BT) survivors have an increased risk of treatment-related late effects, which can reduce health-related quality of life and increase morbidity.
Petra Grahn, Tiina Remes, Reetta Kivisaari, Maria H. Suo-Palosaari, Pekka M. Arikoski, Päivi K. T. Koskenkorva, Päivi M. Lähteenmäki, Tuula R. I. Lönnqvist, Marja K. Ojaniemi, Kirsti H. Sirkiä, Anna K. Sutela, Sanna-Maria Toiviainen-Salo, Heikki M. J. Rantala, Arja H. Harila, Jaakko Niinimäki, Jaro Karppinen, Matti Ahonen   +16 more
doaj   +1 more source

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source

In Situ Stress‐Dispersing Hydrogel Millispheres via Load Redistribution to Restore Nucleus Pulposus Metabolic Homeostasis

Advanced Science, EarlyView.
Local stress concentration disrupts metabolic homeostasis and induces inflammation in the nucleus pulposus (NP), thereby accelerating intervertebral disc degeneration (IDD). A biomimetic HA/ChS hydrogel millimeter sphere (ChS@HM) is developed to enable synergistic stress dispersion and sustained hydration lubrication.
Ang Li, Hui Yuan, Honglei Xiao, Xiaodong Liu, Wenguo Cui   +4 more
wiley   +1 more source

Lumbar Degenerative Disc Disease: Current and Future Concepts of Diagnosis and Management

Advances in Orthopedics, 2012
Low back pain as a result of degenerative disc disease imparts a large socioeconomic impact on the health care system. Traditional concepts for treatment of lumbar disc degeneration have aimed at symptomatic relief by limiting motion in the lumbar spine,
Fadi Taher, David Essig, Darren R. Lebl, Alexander P. Hughes, Andrew A. Sama, Frank P. Cammisa, Federico P. Girardi   +6 more
doaj   +1 more source

Relative Contribution of Upper and Lower Lumbar Spinal Segments to Flexion/Extension: Comparison between Normal Spines and Spines with Disc Disease in Asian Patients [PDF]

Asian Spine Journal, 2015
Study DesignProspective cohort study.PurposeTo evaluate the contribution of upper and lower lumbar segments to flexion and extension of the lumbar spine in normal and diseased spines.Overview of LiteratureThe specific contributions of upper and lower ...
Tarun Bali, Malhar N. Kumar
doaj   +1 more source

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

Dual‐Gene Edited Extracellular Vesicles Remodel the Redox Homeostasis to Inhibit Ferroptosis in Intervertebral Disc Degeneration

Advanced Science, EarlyView.
ABSTRACT Intervertebral disc degeneration (IDD) is driven by ferroptosis of nucleus pulposus cells (NPCs) as a core pathological mechanism. Nucleus pulposus progenitor cells (NPPCs), exhibiting stem cell‐like properties, yield extracellular vesicles (PEVs) with high affinity for NPCs and enable targeted phenotypic regulation.
Jing Yan, Yazhou Lin, Shuo Miao, Minghao Chao, Chengbai Dai, Ziwen Hao, Rui Chen, Ming Guan, Bin Pan, Fenglei Gao, Quan Zhou   +10 more
wiley   +1 more source

Hypertension is Independently Associated with Lumbar Disc Degeneration: A Large-Scale Population-Based Study

Global Spine Journal, 2014
Introduction Low back pain (LBP) is the most disabling condition in the world. Lumbar intervertebral disc degeneration is one of the risk factors for LBP. In particular, specific clinically relevant phenotypes of degeneration, such as moderate and severe
D. Samartzis, C. Bow, J. Karppinen, K. D. K. Luk, B. M. Y. Cheung, K. M. C. Cheung   +5 more
doaj   +1 more source

A comparative study to evaluate disc degeneration on magnetic resonance imaging in patients with chronic low back pain and asymptomatic individuals

Journal of Orthopaedics, Trauma and Rehabilitation, 2021
Objectives The present study aimed to investigate the association of disc degeneration with low back pain and the effect of ageing on disc degeneration in low back pain versus asymptomatic individuals.
Roop Singh, Pradeep Kumar, Jitendra Wadhwani, Rohtas K Yadav, Mohit Khanna, Svareen Kaur   +5 more
doaj   +1 more source