Results 101 to 110 of about 4,650,441 (339)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

LUNG FUNCTION STUDIES. V. RESPIRATORY DEAD SPACE IN OLD AGE AND IN PULMONARY EMPHYSEMA 1 [PDF]

, 1950
Ward S. Fowler
openalex   +1 more source

Chronic fetal hypoxia and antenatal Vitamin C exposure differentially regulate molecular signalling in the lung of female lambs in early adulthood

Frontiers in Physiology
IntroductionChronic fetal hypoxia is commonly associated with fetal growth restriction and can predispose to respiratory disease at birth and in later life. Antenatal antioxidant treatment has been investigated to overcome the effects of oxidative stress
Erin V. McGillick, Erin V. McGillick, Sandra Orgeig, Beth J. Allison, Kirsty L. Brain, Melanie R. Bertossa, Stacey L. Holman, Ashley S. Meakin, Michael D. Wiese, Youguo Niu, Nozomi Itani, Katie L. Skeffington, Christian Beck, Kimberly J. Botting-Lawford, Janna L. Morrison, Janna L. Morrison, Dino A. Giussani   +16 more
doaj   +1 more source

Natural Killer Cells in the Lungs

Frontiers in Immunology, 2019
The lungs, a special site that is frequently challenged by tumors, pathogens and other environmental insults, are populated by large numbers of innate immune cells. Among these, natural killer (NK) cells are gaining increasing attention.
Jingjing Cong, Jingjing Cong, Jingjing Cong, Haiming Wei, Haiming Wei   +4 more
doaj   +1 more source

Smoking and Lung Cancer [PDF]

, 1953
Richard Doll, A. B. Hill
openalex   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Candida dubliniensis breast implant infection in a lung transplant recipient

JHLT Open
This report details the case of a lung transplant recipient with a remote history of breast cancer and breast reconstruction with implants, who received lengthy antifungal therapy for a post-transplant donor-transmitted Candida dubliniensis empyema ...
Ashley Barnes, MD, Kristen Broderick, MD, Errol Bush, MD, Jonathan Orens, MD, Melanie Marashly, CRNP, Shmuel Shoham, MD, Robin Avery, MD   +6 more
doaj   +1 more source

TWO CASES OF HERNIA OF THE LUNGS INTO THE NECK; ONE VERIFIED BY POST-MORTEM EXAMINATION. [PDF]

, 1885
Maurice Knox
openalex   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source