Results 61 to 70 of about 2,198,200 (198)

Tracking the Evolution of Non‐Small‐Cell Lung Cancer

New England Journal of Medicine, 2017
BACKGROUND Among patients with non‐small‐cell lung cancer (NSCLC), data on intratumor heterogeneity and cancer genome evolution have been limited to small retrospective cohorts.
M. Jamal-Hanjani, G. Wilson, N. Mcgranahan, Nicolai J. Birkbak, T. Watkins, S. Veeriah, S. Shafi, Diana H. Johnson, R. Mitter, R. Rosenthal, M. Salm, S. Horswell, M. Escudero, Nik Matthews, A. Rowan, T. Chambers, D. Moore, S. Turajlic, Hang Xu, S. Lee, M. Forster, T. Ahmad, C. Hiley, C. Abbosh, M. Falzon, E. Borg, T. Marafioti, D. Lawrence, M. Hayward, S. Kolvekar, N. Panagiotopoulos, S. Janes, R. Thakrar, Asia Ahmed, F. Blackhall, Y. Summers, R. Shah, L. Joseph, A. Quinn, P. Crosbie, B. Naidu, G. Middleton, G. Langman, S. Trotter, M. Nicolson, H. Remmen, K. Kerr, M. Chetty, L. Gomersall, D. Fennell, A. Nakas, S. Rathinam, G. Anand, S. Khan, P. Russell, V. Ezhil, Babikir Ismail, Melanie Irvin-sellers, V. Prakash, J. Lester, M. Kornaszewska, R. Attanoos, Haydn Adams, H. Davies, S. Dentro, P. Tanière, Brendan O’Sullivan, H. Lowe, J. Hartley, N. Iles, Harriet Bell, Y. Ngai, J. Shaw, Javier Herrero, Z. Szallasi, R. Schwarz, A. Stewart, S. Quezada, J. Le Quesne, P. Van Loo, C. Dive, A. Hackshaw, C. Swanton   +82 more
semanticscholar   +1 more source

Impact of molecular diagnostics and targeted cancer therapy on patient outcomes (MODIFY): a retrospective study of the implementation of precision oncology

Molecular Oncology, EarlyView.
The authors conducted a retrospective study of 94 patients with advanced cancer who underwent next‐generation sequencing (NGS) gene panel analysis and received targeted treatments when applicable. Results further support evidence indicating that molecular profiling provides clinical benefit.
Michaël Dang, Anna Schritz, Nikolai Goncharenko, Guy Berchem   +3 more
wiley   +1 more source

Polyfunctional CD8+CD226+RUNX2hi effector T cells are diminished in advanced stages of chronic lymphocytic leukemia

Molecular Oncology, EarlyView.
CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar, Shima Shahbaz, Anthea C. Peters, Spencer B. Gibson, Shokrollah Elahi   +4 more
wiley   +1 more source

Factors modulating 99mTc‐MAA planar lung dosimetry for 90Y radioembolization

Journal of Applied Clinical Medical Physics, Volume 23, Issue 12, December 2022., 2022
Abstract Purpose To investigate the accuracy and biases of predicted lung shunt fraction (LSF) and lung dose (LD) calculations via 99mTc‐macro‐aggregated albumin (99mTc‐MAA) planar imaging for treatment planning of 90Y‐microsphere radioembolization.
Benjamin P. Lopez, Armeen Mahvash, James P. Long, Marnix G. E. H. Lam, S. Cheenu Kappadath   +4 more
wiley   +1 more source

On the Rate of Diffusion of Carbonic Oxide into the Lungs of Man¹ [PDF]

, 1910
August Krogh, Marie Krogh
openalex   +1 more source

Global Initiative for Chronic Obstructive Lung Disease (GOLD)

, 2017
not available Anwer Khan Modern Medical College Journal Vol. 7, No.
Mahmudur Rahman, M. R. Siddiqui
semanticscholar   +1 more source

Comprehensive genomic characterization of squamous cell lung cancers

Nature, 2012
Lung squamous cell carcinoma is a common type of lung cancer, causing approximately 400,000 deaths per year worldwide. Genomic alterations in squamous cell lung cancers have not been comprehensively characterized, and no molecularly targeted agents have ...
P. Hammerman, Douglas Voet, M. Lawrence, Douglas Voet, R. Jing, K. Cibulskis, A. Sivachenko, P. Stojanov, A. McKenna, E. Lander, S. Gabriel, G. Getz, M. Imieliński, E. Helman, Bryan Hernandez, Nam Pho, M. Meyerson, Andy Chu, Jung E. Hye-Chun, A. Mungall, E. Pleasance, A. G. Robertson, Payal Sipahimalani, D. Stoll, M. Balasundaram, I. Birol, Y. Butterfield, E. Chuah, R. Coope, R. Corbett, Noreen Dhalla, R. Guin, A. He, Carrie Hirst, M. Hirst, R. Holt, Darlene Lee, H. Li, Michael Mayo, Richard A. Moore, K. Mungall, K. Nip, A. Olshen, J. Schein, Jared R. Slobodan, Angela Tam, N. Thiessen, R. Varhol, Thomas Zeng, Yongjun Zhao, Steven J. M. Jones, M. Marra, G. Saksena, A. Cherniack, S. Schumacher, B. Tabak, S. Carter, Huy L. Nguyen, R. Onofrio, A. Crenshaw, K. Ardlie, R. Beroukhim, W. Winckler, A. Protopopov, Jianhua Zhang, Angela Hadjipanayis, Semin Lee, Ruibin Xi, Lixing Yang, X. Ren, Hailei Zhang, S. Shukla, Peng-Chieh Chen, Psalm S. Haseley, E. Lee, L. Chin, P. Park, R. Kucherlapati, N. Socci, Yupu Liang, N. Schultz, L. Borsu, A. Lash, A. Viale, C. Sander, M. Ladanyi, J. Auman, K. Hoadley, M. Wilkerson, Yan Shi, C. Liquori, S. Meng, Ling Li, Yidi J. Turman, M. D. Topal, Donghui Tan, S. Waring, Elizabeth Buda, Jesse L. Walsh, Corbin D. Jones, P. Mieczkowski, Darshan Singh, Junyuan Wu, Anisha Gulabani, Peter Dolina, T. Bodenheimer, A. Hoyle, J. Simons, Matthew G. Soloway, Joshua M. Stuart, Lisle E. Mose, S. Jefferys, S. Balu, Brian D. O’Connor, Derek Y. Chiang, Jinze Liu, D. Hayes, C. Perou, L. Cope, D. Weisenberger, Ludmila V. Danilova, D. Weisenberger, D. Maglinte, F. Pan, D. V. Berg, T. Triche, J. Herman, S. Baylin, P. Laird, M. Noble, Nils Gehlenborg, D. Dicara, Jinhua Zhang, Chang-Jiun Wu, Spring Yingchun Liu, L. Zou, Pei Lin, Juok Cho, Marc-Danie Nazaire, James Robinson, H. Thorvaldsdóttir, J. Mesirov, Rileen Sinha, G. Ciriello, E. Cerami, Benjamin E. Gross, A. Jacobsen, Jianjiong Gao, B. A. Aksoy, Nils Weinhold, Ricardo Ramirez, B. Taylor, Yevgeniy Antipin, B. Reva, Qianxing Mo, V. Seshan, P. Paik, Rehan Akbani, Nianxiang Zhang, B. Broom, Tod D. Casasent, A. Unruh, Chris Wakefield, R. Cason, K. Baggerly, J. Weinstein, D. Haussler, C. Benz, Jingchun Zhu, C. Szeto, G. Scott, C. Yau, S. Ng, Theodore Goldstein, Peter Waltman, Artem Sokolov, E. Collisson, K. Ellrott, D. Zerbino, Singer Ma, Brian Craft, Ying Du, Christopher R. Cabanski, Vonn Walter, J. Marron, Yufeng Liu, Kai Wang, J. Prins, C. Creighton, Yiqun Zhang, W. Travis, N. Rekhtman, Joanne E. Yi, M. Aubry, R. Cheney, S. Dacic, D. Flieder, W. Funkhouser, P. Illei, J. Myers, M. Tsao, R. Penny, D. Mallery, T. Shelton, M. Hatfield, S. Morris, P. Yena, C. Shelton, M. Sherman, J. Paulauskis, R. Govindan, I. Azodo, D. Beer, R. Bose, L. Byers, D. Carbone, Li-Wei Chang, Elizabeth Chun, L. Ding, J. Heymach, C. Ida, B. Johnson, I. Jurisica, J. Kaufman, F. Kosari, D. Kwiatkowski, C. Maher, A. Mungall, W. Pao, M. Peifer, Gordon Robertson, V. Rusch, J. Siegfried, C. Sougnez, Roman K. Thomas, S. Tomaszek, Charles J. Vaske, D. Wheeler, D. Wigle, C. Wilks, J. Zhang, M. Jensen, R. Sfeir, A. Kahn, A. Chu, Prachi Kothiyal, Zhining Wang, E. Snyder, J. Pontius, T. Pihl, Brenda Ayala, M. Backus, Jessica L Walton, J. Baboud, D. Berton, M. Nicholls, Deepak Srinivasan, R. Raman, Stanley Girshik, Peter A. Kigonya, S. Alonso, Rashmi N. Sanbhadti, S. Barletta, J. Greene, D. Pot, B. Bandarchi-Chamkhaleh, J. Boyd, J. Weaver, I. Azodo, C. Ida, Ping Yang, M. Brock, K. Rogers, M. Rutledge, T. Brown, Beverly Lee, James Shin, D. Trusty, R. Dhir, O. Potapova, K. Fedosenko, Elena Nemirovich-Danchenko, M. Zakowski, M. Iacocca, Jennifer Brown, B. Rabeno, Christine Czerwinski, N. Petrelli, Zhen Fan, N. Todaro, J. Eckman, W. Rathmell, L. Thorne, Meijuan Huang, L. Boice, Ashley D. Hill, Erin E. Curley, C. Morrison, Carmelo Gaudioso, J. Bartlett, S. Kodeeswaran, B. Zanke, H. Sekhon, K. David, H. Juhl, X. Le, B. Kohl, Richard A. Thorp, N. V. Tien, N. V. Bang, H. Sussman, Bui Duc Phu, R. Hajek, N. P. Hung, K. Z. Khan, T. Muley, K. Shaw, Margi Sheth, Liming Yang, K. Buetow, Tanja Davidsen, John A. Demchok, G. Eley, M. Ferguson, Laura A. L. Dillon, C. Schaefer, M. Guyer, B. Ozenberger, Jacqueline D. Palchik, Jane L. Peterson, H. Sofia, E. Thomson, R. Shen   +332 more
semanticscholar   +1 more source

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

Molecular Oncology, EarlyView.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy, Heather Fairfield, Victoria E. DeMambro, Samaa Fadel, Carlos A. Gartner, Michelle Karam, Christian Potts, Princess Rodriguez, Ya‐Wei Qiang, Habib Hamidi, Xiangnan Guan, Calvin P. H. Vary, Michaela R. Reagan   +12 more
wiley   +1 more source

Feasibility of radical cardiac‐sparing, treatment planning strategies for patients with locally advanced, non‐small cell lung cancer

Journal of Applied Clinical Medical Physics, Volume 23, Issue 12, December 2022., 2022
Abstract Purpose A set of treatment planning strategies were designed and retrospectively implemented for locally advanced, non‐small cell lung cancer (NSCLC) patients in order to minimize cardiac dose without compromising target coverage goals. Methods Retrospective analysis was performed for 20 NSCLC patients prescribed to 60–66 Gy that received a ...
Joshua P. Kim, Jake Dewalt, Aharon Feldman, Khaled Adil, Benjamin Movsas, Indrin J. Chetty   +5 more
wiley   +1 more source

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

Molecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia, Anouk C. de Jong, Lisanne F. van Dessel, Vanja de Weerd, Corine Beaufort, Jean Helmijr, José Alberto Nakauma‐González, Job van Riet, Paul Hamberg, Daniel Vis, Michiel S. van der Heijden, Nick Beije, Martijn P. Lolkema, Teoman Deger, Saskia M. Wilting, Ronald de Wit, Maurice P. H. M. Jansen, John W. M. Martens   +17 more
wiley   +1 more source