Results 61 to 70 of about 3,948,840 (323)

Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients

Molecular Oncology, EarlyView.
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink, Leon W. M. M. Terstappen, Eshwari Dathathri, Khrystany Isebia, Jaco Kraan, John Martens, Ruchi Bansal   +6 more
wiley   +1 more source

Pulmonary sequestration: an experience in a level III hospital

Journal of Pediatric and Neonatal Individualized Medicine, 2019
Background: Pulmonary Sequestration (PS) is a rare congenital malformation, with few cases reported. Thus, the prenatal and postnatal natural history of PS and the best management approach have not been fully characterized.
Catarina Neves, Carla Ramalho, Inês Azevedo, Ana Catarina Fragoso, Gustavo Rocha, Hercília Guimarães   +5 more
doaj   +1 more source

Combating COVID-19: MVA Vector Vaccines Applied to the Respiratory Tract as Promising Approach Toward Protective Immunity in the Lung

Frontiers in Immunology, 2020
The lung is the vital target organ of coronavirus disease 2019 (COVID-19) caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Reinhold Förster, Reinhold Förster, Henrike Fleige, Gerd Sutter, Gerd Sutter   +4 more
doaj   +1 more source

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Incidence and outcomes of acute lung injury.

New England Journal of Medicine, 2005
BACKGROUND Acute lung injury is a critical illness syndrome consisting of acute hypoxemic respiratory failure with bilateral pulmonary infiltrates that are not attributed to left atrial hypertension.
G. Rubenfeld, E. Caldwell, E. Peabody, J. Weaver, Diane P. Martin, M. Neff, E. Stern, L. Hudson   +7 more
semanticscholar   +1 more source

Impaired FGF10 Signaling and Epithelial Development in Experimental Lung Hypoplasia With Esophageal Atresia

Frontiers in Pediatrics, 2018
Patients with esophageal atresia (EA) and tracheoesophageal fistula (TEF) often experience persistent respiratory tract disease. In experimental models, doxorubicin-induced developmental lung abnormalities may result from downregulation of branching ...
Jun Wang, Jun Wang, Hao Liu, Linlin Gao, Xiaomei Liu   +4 more
doaj   +1 more source

Umbilical Cord Blood Cells Do Not Reduce Ventilation-Induced Lung Injury in Preterm Lambs

Frontiers in Physiology, 2020
BackgroundPreterm infants often have immature lungs and, consequently, many require respiratory support at birth. However, respiratory support causes lung inflammation and injury, termed ventilation-induced lung injury (VILI).
Madeleine J. Smith, Kyra Y. Y. Chan, Paris Papagianis, Paris Papagianis, Ilias Nitsos, Valerie Zahra, Beth Allison, Graeme R. Polglase, Courtney A. McDonald   +8 more
doaj   +1 more source

MESAHA-Net: Multi-Encoders based Self-Adaptive Hard Attention Network with Maximum Intensity Projections for Lung Nodule Segmentation in CT Scan [PDF]

arXiv, 2023
Accurate lung nodule segmentation is crucial for early-stage lung cancer diagnosis, as it can substantially enhance patient survival rates. Computed tomography (CT) images are widely employed for early diagnosis in lung nodule analysis. However, the heterogeneity of lung nodules, size diversity, and the complexity of the surrounding environment pose ...
arxiv  

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source

Adaptive Immunity in Pulmonary Sarcoidosis and Chronic Beryllium Disease

Frontiers in Immunology, 2020
Pulmonary sarcoidosis and chronic beryllium disease (CBD) are inflammatory granulomatous lung diseases defined by the presence of non-caseating granulomas in the lung.
Sarah A. Greaves, Shaikh M. Atif, Andrew P. Fontenot, Andrew P. Fontenot   +3 more
doaj   +1 more source