Results 81 to 90 of about 3,948,840 (323)

Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer.

New England Journal of Medicine, 2010
BACKGROUND Oncogenic fusion genes consisting of EML4 and anaplastic lymphoma kinase (ALK) are present in a subgroup of non-small-cell lung cancers, representing 2 to 7% of such tumors. We explored the therapeutic efficacy of inhibiting ALK in such tumors
E. Kwak, Y. Bang, D. Camidge, A. Shaw, B. Solomon, Robert G. Maki, Sai-Hong Ignatius Ou, B. Dezube, P. Jänne, Daniel, B. Costa, M. Varella-Garcia, W. Kim, Thomas J. Lynch, P. Fidias, Hannah Stubbs, J. Engelman, V. Lecia, Sequist, Weiwei Tan, L. Gandhi, M. Mino‐Kenudson, Greg C. Wei, S. M. Shreeve, M. Ratain, Jeffrey, Settleman, James G. Christensen, D. A. Haber, K. Wilner, R. Salgia, Geoffrey I. Shapiro, J. Clark, A. Iafrate   +33 more
semanticscholar   +1 more source

Past and future of stem cells: from Prometheus to regenerative medicine

Journal of Pediatric and Neonatal Individualized Medicine, 2016
The salamander limb regenerates completely after amputation and the heart of the zebrafish returns to normal even after an extensive injury. What is it that makes all this possible?
Gavino Faa, Vassilios Fanos, Antonio Giordano   +2 more
doaj   +1 more source

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

Early palliative care for patients with metastatic non-small-cell lung cancer.

New England Journal of Medicine, 2010
BACKGROUND Patients with metastatic non-small-cell lung cancer have a substantial symptom burden and may receive aggressive care at the end of life. We examined the effect of introducing palliative care early after diagnosis on patient-reported outcomes ...
J. Temel, J. Greer, A. Muzikansky, E. Gallagher, S. Admane, V. Jackson, C. Dahlin, C. Blinderman, J. Jacobsen, W. Pirl, J. Billings, T. Lynch   +11 more
semanticscholar   +1 more source

The structure of the normalisers of the congruence subgroups of the Hecke group $G_5$ [PDF]

arXiv, 2006
We determine the normalisers of congruence subgroups of $G_5$.
arxiv  

Combined spatially resolved metabolomics and spatial transcriptomics reveal the mechanism of RACK1‐mediated fatty acid synthesis

Molecular Oncology, EarlyView.
The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu, Jinqiu Li, Junqi Ma, Ayshamgul Hasim   +3 more
wiley   +1 more source

A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injury

Nature Network Boston, 2005
During several months of 2003, a newly identified illness termed severe acute respiratory syndrome (SARS) spread rapidly through the world. A new coronavirus (SARS-CoV) was identified as the SARS pathogen, which triggered severe pneumonia and acute ...
K. Kuba, Y. Imai, Shuan Rao, Hong Gao, F. Guo, Bin Guan, Yi Huan, Peng‐fei Yang, Yanli Zhang, Wei Deng, L. Bao, Binlin Zhang, Guang Liu, Z. Wang, M. Chappell, Yan-xin Liu, D. Zheng, A. Leibbrandt, T. Wada, Arthur S Slutsky, De-Pei Liu, C. Qin, Chengyu Jiang, J. Penninger   +23 more
semanticscholar   +1 more source

Skin metastasis of lung carcinoma

The Pan African Medical Journal, 2015
A 61-year-old male was admitted to the hospital with tumors in the scalp (A), face (B), and neck (C) that had been present for four month with an acute decrease in visual acuity. These tumors have progressed to ulceration.
Krich Sanaa, Mernissi Fatima Zahra
doaj   +1 more source

Post-transplant lymphoproliferative disorder presenting as CD20-negative plasmablastic lymphoma in the lung

Rare Tumors, 2016
Post-transplant lymphoproliferative disorders (PTLD) are a serious complication of transplantation with a high mortality. Most PTLD present within the first year of transplantation and are associated with Epstein-Barr virus (EBV) infection. Plasmablastic
Tasneem Kaleem, Jennifer A. Crozier, David M. Menke, Taimur Sher   +3 more
doaj   +1 more source

Stabilizing Cellular Barriers: Raising the Shields Against COVID-19

Frontiers in Endocrinology, 2020
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its clinical manifestation (COVID-19; coronavirus disease 2019) have caused a worldwide health crisis.
Julia Hanchard, Julia Hanchard, Julia Hanchard, Coral M. Capó-Vélez, Kai Deusch, Darcy Lidington, Darcy Lidington, Darcy Lidington, Steffen-Sebastian Bolz, Steffen-Sebastian Bolz, Steffen-Sebastian Bolz   +10 more
doaj   +1 more source