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Immune Resistance in Lung Adenocarcinoma [PDF]

Cancers, 2021
Lung cancer is the leading cancer killer worldwide, imposing grievous challenges for patients and clinicians. The incidence of lung adenocarcinoma (LUAD), the main histologic subtype of lung cancer, is still increasing in current-, ex-, and even non-smokers, whereas its five-year survival rate is approximately 15% as the vast majority of patients ...
Magda Spella, Georgios T. Stathopoulos
openaire   +4 more sources

Micropapillary Lung Adenocarcinoma [PDF]

American Journal of Clinical Pathology, 2009
Abstract Micropapillary lung adenocarcinoma (MPA) has been reported as an aggressive variant of adenocarcinoma, frequently manifesting at high stage with a poor prognosis. We analyzed the clinical and molecular profile of 15 primary MPAs for K-ras, EGFR, and BRAF mutations and performed fluorescence in situ hybridization for EGFR ...
Rosane De Oliveira Duarte Achcar, Marina N. Nikiforova, Samuel A. Yousem   +2 more
openalex   +3 more sources

ATF1 promotes the malignancy of lung adenocarcinoma cells by transcriptionally regulating ZNF143 expression

Acta Biochimica et Biophysica Sinica, 2023
The clinical oncogenic functions and mechanisms of activating transcription factor 1 (ATF1) in the progression of lung adenocarcinoma have not been completely elucidated.
Mei Jinhong, Liu Yu, Sheng Yiyun, Liu Ying, Chen Limin, Wang Hailong, Cheng Minzhang, Zhai Zhenyu, Xu Linlin   +8 more
doaj   +1 more source

Epidemiological characteristics and risk factors of lung adenocarcinoma: A retrospective observational study from North China

Frontiers in Oncology, 2022
BackgroundThe main aim of the study was to determine the risk factors of lung adenocarcinoma and to analyze the variations in the incidence of lung adenocarcinoma according to time, sex, and smoking status in North China.MethodsPatients with lung cancer ...
Daojuan Li, Jin Shi, Xiaoping Dong, Di Liang, Jing Jin, Yutong He   +5 more
doaj   +1 more source

High GNG4 expression is associated with poor prognosis in patients with lung adenocarcinoma

Thoracic Cancer, 2022
Background The purpose of this study was to explore the reason for guanine nucleotide binding‐protein gamma subunit‐4 (GNG4) overexpression and the relationship between GNG4 overexpression and the poor prognosis of lung adenocarcinoma (LUAD) patients ...
Bodong Zhou, Wenbo Zhu, Shuai Yuan, Yifei Wang, Qing Zhang, Hong Zheng, Lei Zhu, Jie Xu   +7 more
doaj   +1 more source

Expression of MAD2L1 in Lung Adenocarcinoma and Its Effect on Immune Microenvironment

Zhongliu Fangzhi Yanjiu, 2022
Objective To investigate the expression of MAD2L1 in lung adenocarcinoma and its effect on the prognosis and immune microenvironment of patients. Methods The difference of MAD2L1 expression in lung adenocarcinoma tissue and normal lung tissue was ...
LIU Yingbo, LIU Xiaohong, RU Meihua, LI Jianqiang   +3 more
doaj   +1 more source

UCHL1 acts as a potential oncogene and affects sensitivity of common anti-tumor drugs in lung adenocarcinoma

World Journal of Surgical Oncology, 2022
Background Lung adenocarcinoma is the leading cause of cancer death worldwide. Recently, ubiquitin C-terminal hydrolase L1 (UCHL1) has been demonstrated to be highly expressed in many tumors and plays the role of an oncogene.
Jianbo Yao, Abdusemer Reyimu, Ao Sun, Zaxi Duoji, Wubi Zhou, Song Liang, Suxia Hu, Xiang Wang, Jingjing Dai, Xiaoguang Xu   +9 more
doaj   +1 more source

ARNTL2 is an indicator of poor prognosis, promotes epithelial-to-mesenchymal transition and inhibits ferroptosis in lung adenocarcinoma

Translational Oncology, 2022
Objectives: ARNTL2, as a circadian transcription factor, has been recently proposed to play an important role in a variety of tumors. however, the role of ARNTL2 in lung carcinogenesis and progression remains unclear.
Huan Zhang, Guangyao Shan, Xing Jin, Xiangyang Yu, GuoShu Bi, Mingxiang Feng, Hao Wang, Miao Lin, Cheng Zhan, Qun Wang, Ming Li   +10 more
doaj   +1 more source

Expression of LDL receptor-related proteins (LRPs) in common solid malignancies correlates with patient survival [PDF]

, 2017
LDL receptor-related proteins (LRPs) are transmembrane receptors involved in endocytosis, cell-signaling, and trafficking of other cellular proteins. Considerable work has focused on LRPs in the fields of vascular biology and neurobiology.
Gilder, Andrew S., Gonias, Steven L., Karimi-Mostowfi, Nicki, Mantuano, Elisabetta, Murray, Sarah S.   +4 more
core   +10 more sources

An integrated genomic analysis of lung cancer reveals loss of DUSP4 in EGFR-mutant tumors. [PDF]

, 2009
To address the biological heterogeneity of lung cancer, we studied 199 lung adenocarcinomas by integrating genome-wide data on copy number alterations and gene expression with full annotation for major known somatic mutations in this cancer.
Brennan, C, Broderick, S, Chitale, D, Gerald, W, Golas, B, Gong, Y, Ladanyi, M, Major, J, Motoi, N, Pao, W, Reinersman, J, Rusch, V, Sander, C, Seshan, V, Somwar, R, Szoke, J, Taylor, Barry, Wang, L, Zakowski, M   +18 more
core   +5 more sources