Lung adenocarcinoma - Open Access .click

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miR-625-5p promotes proliferation and invasion of lung adenocarcinoma by targeting PRKACA [PDF]

Zhongguo aizheng zazhi, 2021
Background and purpose: Lung adenocarcinoma is a subtype of non-small cell lung cancer. Although much progress has been made in the diagnosis and treatment of lung adenocarcinoma, the clinical prognosis and overall survival of advanced lung ...
HU Yaqiong , BAI Jun , CHEN Lin , CHEN Xinlu , ZHANG Liping , ZHOU Dandan , WANG Yu , YIN Chonggao , LI Hongli , LIU Yuqing
doaj +1 more source

Decoding the multicellular ecosystem of lung adenocarcinoma manifested as pulmonary subsolid nodules by single-cell RNA sequencing

Science Advances, 2021
Lung adenocarcinoma manifesting as radiological subsolid nodules has distinct cell composition within its tumor microenvironment. Lung adenocarcinomas (LUAD) that radiologically display as subsolid nodules (SSNs) exhibit more indolent biological behavior
Xudong Xing +7 more
semanticscholar +1 more source

Evolutionary metabolic landscape from preneoplasia to invasive lung adenocarcinoma

Nature Communications, 2021
Metabolic reprogramming evolves during cancer initiation and progression. However, thorough understanding of metabolic evolution from preneoplasia to lung adenocarcinoma (LUAD) is still limited.
Meng Nie +10 more
semanticscholar +1 more source

Single-cell RNA sequencing demonstrates the molecular and cellular reprogramming of metastatic lung adenocarcinoma

Nature Communications, 2020
Advanced metastatic cancer poses utmost clinical challenges and may present molecular and cellular features distinct from an early-stage cancer. Herein, we present single-cell transcriptome profiling of metastatic lung adenocarcinoma, the most prevalent ...
N. Kim +20 more
semanticscholar +1 more source

Non-genetic evolution drives lung adenocarcinoma spatial heterogeneity and progression.

Cancer Discovery, 2021
Cancer evolution determines molecular and morphological intra-tumor heterogeneity and challenges the design of effective treatments. In lung adenocarcinoma, disease progression and prognosis are associated with the appearance of morphologically diverse ...
Daniele Tavernari +12 more
semanticscholar +1 more source

Deciphering cell lineage specification of human lung adenocarcinoma with single-cell RNA sequencing

Nature Communications, 2021
Lung adenocarcinomas (LUAD) arise from precancerous lesions such as atypical adenomatous hyperplasia, which progress into adenocarcinoma in situ and minimally invasive adenocarcinoma, then finally into invasive adenocarcinoma.
Zhoufeng Wang +18 more
semanticscholar +1 more source

Massive malignant pleural effusion due to lung adenocarcinoma in 13-year-old boy [PDF]

, 2016
A 13-year-old boy with no risk factors for lung cancer presented with a massive left-sided pleural effusion and a mediastinal shift on chest radiography and computed tomography. A chest tube drained bloody pleural fluid with an exudative pattern.
Afghani, R. +5 more
core +1 more source

Lung adenocarcinoma presenting as interstitial lung disease [PDF]

BMJ Case Reports, 2020
A 59-year-old Caucasian woman presented with a 3-month history of worsening dyspnoea and productive cough with clear mucoid sputum. She also had episodic chills, night sweats and an unintentional 11 kg weight loss. She denied any fever, haemoptysis, recent travel or sick contacts.
Aditya Mehta +3 more
openaire +2 more sources

Comprehensive molecular profiling of lung adenocarcinoma

Nature, 2014
Adenocarcinoma of the lung is the leading cause of cancer death worldwide. Here we report molecular profiling of 230 resected lung adenocarcinomas using messenger RNA, microRNA and DNA sequencing integrated with copy number, methylation and proteomic ...
Eric A. Joshua D. Angela N. Alice H. William Juliann Da Collisson Campbell Brooks Berger Lee Chmielecki Be +356 more
semanticscholar +1 more source

BRD7 Acts as a Tumor Suppressor Gene in Lung Adenocarcinoma. [PDF]

PLoS ONE, 2016
Lung cancer is one of the most malignant tumors and the leading cause of cancer-related deaths worldwide. Among lung cancers, 40% are diagnosed as adenocarcinoma. Bromodomain containing 7 (BRD7) is a member of bromodomain-containing protein family.
Yushun Gao, Bing Wang, Shugeng Gao
doaj +1 more source

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