Results 41 to 50 of about 612,549 (305)

Cannabinoid receptor CB2 drives HER2 pro-oncogenic signaling in breast cancer [PDF]

, 2015
Pharmacological activation of cannabinoid receptors elicits antitumoral responses in different models of cancer. However, the biological role of these receptors in tumor physio-pathology is still unknown.
Alkatout, Ibrahim, Andradas, Clara, Arnold, Norbert, Artola, Marta, Bauer, Maret, Blasco-Benito, Sandra, Bronsert, Peter, Caffarel, María M., Canela, Enric I., Fernández-Piqueras, José, Flores, Juana M., García-Taboada, Elena, Guzmán, Manuel, Hamann, Sigrid, Klapper, Wolfram, Martín-Villar, Ester, McCormick, Peter J., Megías, Diego, Moreno, Estefanía, Moreno-Bueno, Gema, Ortega-Gutiérrez, Silvia, Pérez-Gómez, Eduardo, Pérez-Martínez, Manuel, Quintanilla, Miguel, Röcken, Christoph, Soriano, Joaquim, Staebler, Annette, Stickeler, Elmar, Sánchez, Cristina, Villa-Morales, María, Vázquez-Villa, Henar, Wenners, Antonia   +31 more
core   +1 more source

Expression and Significance of IKBKB in Pulmonary Adenocarcinoma A549 Cells and Its Cisplatin-resistant Variant A549/DDP

Chinese Journal of Lung Cancer, 2014
Background and objective Cisplatin-resistance in Lung cancer cells is widespread in the clinical treatment, seriously affecting the effects of the treatment of lung cancer.
Kang QI, Yang LI, Xuebing LI, Fang ZHANG, Yi SHAO, Qinghua ZHOU   +5 more
doaj   +1 more source

Systematic pan-cancer analysis showed that RAD51AP1 was associated with immune microenvironment, tumor stemness, and prognosis

Frontiers in Genetics, 2022
Although RAD51 associated protein 1 (RAD51AP1) is crucial in genome stability maintenance, it also promotes cancer development with an unclear mechanism.
Renwang Liu, Renwang Liu, Guangsheng Zhu, Guangsheng Zhu, Mingbiao Li, Peijun Cao, Peijun Cao, Xuanguang Li, Xuanguang Li, Xiuwen Zhang, Xiuwen Zhang, Hua Huang, Hua Huang, Zuoqing Song, Zuoqing Song, Jun Chen, Jun Chen   +16 more
doaj   +1 more source

Metastatic model of HPV+ oropharyngeal squamous cell carcinoma demonstrates heterogeneity in tumor metastasis [PDF]

, 2016
Human papillomavirus induced (HPV+) cancer incidence is rapidly rising, comprising 60–80% of oropharyngeal squamous cell carcinomas (OPSCCs); while rare, recurrent/metastatic disease accounts for nearly all related deaths.
Coppock, Joseph D, Lee, John H, Lee, Kimberly M, Onken, Michael D, Spanos, William C, Uppaluri, Ravindra, Vermeer, Daniel W, Vermeer, Paola D, Zeng, Erliang   +8 more
core   +2 more sources

Clinical Value of Seven Autoantibodies Against Tumor-Associated Antigens and Tumor Markers in Lung Cancer Patients: A Retrospective Analysis from a Single Institution

Technology in Cancer Research & Treatment
Background: Lung cancer screening is not limited to low dose computed tomography (LDCT). Recently, molecular biomarkers have been shown to have the potential to improve the current state of early lung cancer detection.
Fan Ren MD, Feng Chen MM, Xiaoqian Xu MM, Hong Ni MM, Tong Li MM, Dian Ren MM, Zuoqing Song MD, Gang Chen BM, Jun Chen MD, Song Xu MD   +9 more
doaj   +1 more source

A Highly Efficient In Vitro Site-directed Mutagenesis Protocol for Introducing 
Multiple-site Mutations into Target Genes

Chinese Journal of Lung Cancer, 2014
Background and objective The methods for introducing point mutations into target genes are important for dissecting the relationship of gene structure and function. Up to date, there are numbers of protocols available for the purpose.
Fanrong MENG, Chen CHEN, Yongwen LI, Haisu WAN, Qinghua ZHOU   +4 more
doaj   +1 more source

Survival for Children Diagnosed With Wilms Tumour (2012–2022) Registered in the UK and Ireland Improving Population Outcomes for Renal Tumours of Childhood (IMPORT) Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background The Improving Population Outcomes for Renal Tumours of childhood (IMPORT) is a prospective clinical observational study capturing detailed demographic and outcome data on children and young people diagnosed with renal tumours in the United Kingdom and the Republic of Ireland.
Naomi Ssenyonga, Angela Lopez‐Cortes, Reem Al‐Saadi, Suzanne Tugnait, Kristina Dzhuma, Catriona Duncan, Gordan Vujanic, Tanzina Chowdhury, Claudia Allemani, Michel P. Coleman, Kathy Pritchard‐Jones, the Children's Cancer and Leukaemia Group (CCLG) Renal Tumour Special Interest Group, Hugh Bishop, Anthony McCarthy, Pamela Kearns, Helen Rees, Amos Burke, Meriel Jenney, Jane Pears, Hamish Wallace, Milind Ronghe, Tanzina Chowdhury, Susan Picton, Emma Ross, Lisa Howell, Bernadette Brennan, Gail Halliday, Richard Grundy, Shaun Wilson, Sucheta Vaidya, Daniel Yeomanson, Jessica Bate, Vesna Pavasovic, Jessica Bate, Sabine Irtan, Jesper Brok, Minou Oostveen, Kristina Dzhuma, Mark Weeks, Richard Williams, Mark Powis, Max Pachl, Bruce Okoye, Naima Smeulders, Gordan Vujanic, Oystein Olsen, Tom Watson, Susan Shelmerdine, Dan Saunders, Angela Lopez-Cortes, Taryn Treger, Tom Jackson, Suzanne Tugnait, Lisa Howell, Tanzina Chowdhury, Sam Behjati, Angela Polanco   +56 more
wiley   +1 more source

Construction and Expression of nm23-H1 Gene with Different Enzyme Activities and Resistant Specific shRNA in Eukaryotic Expression Vector

Chinese Journal of Lung Cancer, 2014
Background and objective It has been proven that nm23-H1 gene was a tumor metastatic suppressor gene. However, it’s molecular mechanism of suppressing metastasis remains unexplored.
Zhansheng LU, Lili GUO, Lin LI, Zhihao WU, Qinghua ZHOU   +4 more
doaj   +1 more source

Inducers of epithelial mesenchymal transition and cancer stem cells in malignant pleural effusions [PDF]

, 2016
The Epithelial to Mesenchymal Transition (EMT) plays a role not only in tumor metastasis but also in tumor recurrence. This process is believed to be tightly linked to the presence of Cancer Stem Cells (CSCs) however, it is still not clear which ...
Cherubini, Emanuela, Giarnieri, Enrico, Giovagnoli, Maria Rosaria, Mancini, Rita, Mariotta, Salvatore, Ricci, Alberto   +5 more
core   +1 more source

Stereotactic Body Radiation Therapy for Pediatric, Adolescent, and Young Adult Patients With Osteosarcoma: Local Control Outcomes With Dosimetric Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background/Objectives Osteosarcoma is a radioresistant tumor that may benefit from stereotactic body radiation therapy (SBRT) for locoregional control in metastatic/recurrent disease. We report institutional practice patterns, outcomes, toxicity, and failures in osteosarcoma patients treated with SBRT.
Jenna Kocsis, Shauna R. Campbell, Jonathan Jang, Eashwar Somasundaram, Chandana A. Reddy, Jacob G. Scott, Lilyana Angelov, Peter M. Anderson, Matteo Trucco, Zachary Burke, Lukas Nystrom, Nathan Mesko, Anthony Magnelli, Erin S. Murphy   +13 more
wiley   +1 more source