The immune cell landscape in kidneys of patients with lupus nephritis [PDF]
Nature Immunology, 2019 Lupus nephritis is a potentially fatal autoimmune disease for which the current treatment is ineffective and often toxic. To develop mechanistic hypotheses of disease, we analyzed kidney samples from patients with lupus nephritis and from healthy control
Deepak A Rao +2 more
exaly +4 more sources
Distinct pathogenic roles for resident and monocyte-derived macrophages in lupus nephritis
JCI Insight, 2023 Lupus nephritis is a serious complication of systemic lupus erythematosus, mediated by IgG immune complex (IC) deposition in kidneys, with limited treatment options. Kidney macrophages are critical tissue sentinels that express IgG-binding Fcγ receptors (
Nathan Richoz +14 more
doaj +2 more sources
A neutrophil-mesangial cell axis promotes glomerular injury in lupus nephritis. [PDF]
Ann Rheum DisHanata N +8 more
europepmc +3 more sources
A study on the relationship between morphological lesions of lupus nephritis with demographic and biochemical findings [PDF]
Journal of Preventive Epidemiology, 2022 Introduction: Lupus nephritis is one of the important aspects of systemic lupus erythematosus (SLE). Objectives: This study aimed to investigate possible relationship between pathological lesions of lupus nephritis classes and demographic and biochemical
Nasrin Tavassoli +2 more
doaj +1 more source
Increase in direct costs for health systems due to lupus nephritis: the case of Colombia
Einstein (São Paulo), 2022 Objective Lupus nephritis is one of the most severe complications of systemic lupus erythematosus and it has been estimated that can occur in up to 60% of patients. Direct costs of lupus nephritis have not been studied in developing countries.
Sergio I Prada +3 more
doaj +1 more source
Prognostic relevance of persistent haematuria in patients with lupus nephritis. [PDF]
Clin Kidney JChen X, Li LL, Li N, Wang P, Cao HX.
europepmc +3 more sources
Arthritis & Rheumatology, 2023 AURORA 2 evaluated the long‐term safety, tolerability, and efficacy of voclosporin compared to placebo in patients with lupus nephritis (LN) receiving an additional two years of treatment following completion of the one‐year AURORA 1 study.
Amit Saxena +17 more
semanticscholar +1 more source
Novel Therapeutics for Management of Lupus Nephritis: What Is Next?
Kidney Medicine, 2023 Lupus nephritis is a severe, organ-threatening manifestation of systemic lupus erythematosus. The current standard of care in the treatment of lupus nephritis is limited to broad-spectrum immunosuppressants, which have significant concerns of short- and ...
Sayali B. Thakare +5 more
doaj +1 more source
Cell Death and Disease, 2022 A major cause of proteinuria in lupus nephritis (LN) is podocyte injury, and determining potential therapeutic targets to prevent podocyte injury is important from a clinical perspective in the treatment of LN.
Fu Lv +9 more
semanticscholar +1 more source
Interleukin-17 expression positively correlates with disease severity of lupus nephritis by increasing anti-double-stranded DNA antibody production in a lupus model induced by activated lymphocyte derived DNA. [PDF]
PLoS ONE, 2013 Lupus nephritis is one of the most serious manifestations and one of the strongest predictors of a poor outcome in systemic lupus erythematosus (SLE).
Zhenke Wen +5 more
doaj +1 more source