Results 91 to 100 of about 3,794 (236)

Galanthus krasnovii (amaryllidaceae)'nin toplam fenolik içeriği ile antioksidan kapasitenin değerlendirilmesi [PDF]

, 2019
Natural products have gained the great interest due to their broad spectrum of biological activities. Galanthus krasnovii was dried at shade then extracted with hexane, dichloromethane, and ethyl acetate successively. After removing of solvent by reduced
Elmastaş, Mahfuz, Eminağaoğlu, Özgür, Erenler, Ramazan, Genç, Nusret   +3 more
core  

In search of a cytostatic agent derived from the alkaloid lycorine: Synthesis and growth inhibitory properties of lycorine derivatives [PDF]

Bioorganic & Medicinal Chemistry, 2011
As a continuation of our studies aimed at the development of a new cytostatic agent derived from an Amaryllidaceae alkaloid lycorine, we synthesized 32 analogues of this natural product. This set of synthetic analogues included compounds incorporating selective derivatization of the C1 versus C2 hydroxyl groups, aromatized ring C, lactamized N6 ...
Evdokimov N. M., Lamoral Theys D., Mathieu V., ANDOLFI, ANNA, Frolova L. V., Pelly S. C., van Otterlo W. A. L., Magedov I. V., Kiss R., EVIDENTE, ANTONIO, Kornienko, A.   +10 more
openaire   +4 more sources

Natural products targeting tumour angiogenesis

British Journal of Pharmacology, Volume 182, Issue 10, Page 2094-2136, May 2025.
Abstract Tumour angiogenesis is the formation of new blood vessels to support the growth of a tumour. This process is critical for tumour progression and metastasis, making it an attractive approach to cancer therapy. Natural products derived from plants, animals or microorganisms exert anti‐angiogenic properties and can be used to inhibit tumour ...
Xiaohua Lu, Lara Johanna Friedrich, Thomas Efferth   +2 more
wiley   +1 more source

Evaluation of the antispasmodic and antioxidant activities of an alkaloid extracted from Pancratium foetidum Pom. (Moroccan Endemic Amaryllidaceae) [PDF]

E3S Web of Conferences
Lycorine is a natural alkaloid extracted from the Amaryllidaceae plant family. It has been reported to exhibit a wide range of physiological effects, including the potential effect against cancer.
Bendaif Hajar, Melhaoui Ahmed, Elouadi Yassir, Essadki Samia, Elmsellem Hicham, Benali Taoufiq, Aziz Mohammed, Hafez Baraa, Hachmi Azeddine, Abrigach Farid   +9 more
doaj   +1 more source

Endophytic bacteria from in vitro culture of Leucojum aestivum L. a new source of galanthamine and elicitor of alkaloid biosynthesis

Scientific Reports, 2022
Leucojum aestivum is known for its ability to biosynthesize alkaloids with therapeutic properties, among which galanthamine used for the treatment of Alzheimer's disease. New sources of this alkaloid are still being explored.
Agata Ptak, Emilia Morańska, Marzena Warchoł, Artur Gurgul, Edyta Skrzypek, Michał Dziurka, Dominique Laurain-Mattar, Rosella Spina, Anita Jaglarz, Magdalena Simlat   +9 more
doaj   +1 more source

Department of Metabolic Engineering [PDF]

, 2002
薬物代謝工学部門は和漢薬の薬効，毒性発現に関与する代謝系の分子生物学的研究を発展させることを設置目的とし，①和漢薬の薬効発現に関与する腸内細菌遺伝子の解析，②薬物代謝機能調節遺伝子の解明とその応用，③腎毒性物質産生機構の分子生物学的解明とその制御に関する研究を課題として取りあげ，和漢薬の薬効発現機構，生体へのレスポンスなどの基礎的研究を通じて，和漢薬の科学的評価や臨床応用をはかることを目指している。主な研究題目を以下に示す。1.
中村 憲夫, 宮代 博継, 服部 征雄, 横澤 隆子   +3 more
core   +2 more sources

Lettuce fortification through vitamin B12‐producing bacteria – proof of concept study

Journal of the Science of Food and Agriculture, Volume 105, Issue 6, Page 3343-3354, April 2025.
Abstract BACKGROUND Vitamin B12 (cobalamin) can be produced de novo only by certain bacteria and archaea. It plays a crucial role in the health of animals and humans, which obtain it only through diet, mainly from animal products. This study aimed to identify endophytic bacterial strains capable of synthesizing vitamin B12 and enriching edible plants ...
Sara Pipponzi, Stefanie Primisser, Livio Antonielli, Emilio Stefani, Stephane Compant, Angela Sessitsch, Tanja Kostic   +6 more
wiley   +1 more source

Novel Lycorine Derivatives as Anticancer Agents: Synthesis and In Vitro Biological Evaluation

Molecules, 2014
Lycorine, which is the most abundant alkaloid isolated from the Amaryllidaceae family of plants, reportedly exhibits promising anticancer activities.
Peng Wang, Hui-Hui Yuan, Xue Zhang, Yun-Ping Li, Lu-Qing Shang, Zheng Yin   +5 more
doaj   +1 more source

Lycorine protects motor neurons against TDP-43 proteinopathy-induced degeneration in cross-species models with amyotrophic lateral sclerosis

Pharmacological Research
Aggregation of TAR-DNA binding protein-43 (TDP-43) is a pathological feature present in nearly 97 % cases of amyotrophic lateral sclerosis (ALS), making it an attractive target for pathogenic studies and drug screening.
Jing Wen, Yunhao Li, Yanzhu Qin, Lingli Yan, Ke Zhang, Ang Li, Ziying Wang, Feng Yu, Jianheng Lai, Wei Yang, Yong U. Liu, Dajiang Qin, Huanxing Su   +12 more
doaj   +1 more source

The role of acetylation and deacetylation in cancer metabolism

Clinical and Translational Medicine, Volume 15, Issue 1, January 2025.
Protein acetylation and deacetylation influence metabolic reprogramming in tumour cells by regulating the function and activity of various signalling pathways, transcription factors and metabolic enzymes. Abstract As a hallmark of cancer, metabolic reprogramming adjusts macromolecular synthesis, energy metabolism and redox homeostasis processes to ...
Cuicui Wang, Xiaoxin Ma
wiley   +1 more source