Results 101 to 110 of about 3,794 (236)

Lycorine attenuated proliferation and induced apoptosis on imatinib-resistant K562 cell by inhibiting autophagy

Discover Oncology
Background Tyrosine kinase inhibitor (TKI) resistance is a significant factor exacerbating the burden on chronic myeloid leukemia (CML) patients and impacting clinical efficacy.
Jun Bai, Zuxi Feng, Yaqiong Chen, Yanhong Li, Liansheng Zhang, Lijuan Li   +5 more
doaj   +1 more source

Characterization of the SARS-CoV-2 Mutation Pattern Generated In Vitro by the Antiviral Action of Lycorine

COVID
SARS-CoV-2 persists worldwide, driving the demand for effective antivirals that inhibit replication and limit the emergence of resistant variants.
Silvina Soledad Maidana, Sonia Alejandra Romera, Ana Marandino, Rocío Lucia Tau, Juan Mauel Shammas, Yanina Panzera, Ruben Pérez   +6 more
doaj   +1 more source

Cholinesterase-inhibitory effect and in silico analysis of alkaloids from bulbs of Hieronymiella species [PDF]

, 2018
Background In Argentina, the Amaryllidaceae family (59 species) comprises a wide variety of genera, only a few species have been investigated as a potential source of cholinesterases inhibitors to treat Alzheimer disease (AD).
Agüero, María Belén, Bastida, Jaume, Enriz, Ricardo Daniel, Feresin, Gabriela Egly, Garro, Adriana, Ortiz, Javier Esteban, Pigni, Natalia Belen, Roitman, Gustavo Germán, Slanis, Alberto Carlos, Tapia, Aníbal Alejandro   +9 more
core   +1 more source

Galanthus woronowii (amaryllidaceae)'nin antioksidan aktivitesi ve toplam fenolik içeriği [PDF]

, 2019
Plants have been used for medicinal purpose since ancient times. Due to the including bioactive secondary metabolites, plants have gained the great interest for drug discovery and development process.
Eminağaoğlu, Özgür, Erenler, Ramazan, Genç, Nusret   +2 more
core  

Lycorine Derivative LY-55 Inhibits EV71 and CVA16 Replication Through Downregulating Autophagy

Frontiers in Cellular and Infection Microbiology, 2019
Hand, foot, and mouth disease (HFMD) is a global health concern, especially in the Asia-Pacific region. HFMD caused by Enterovirus 71 (EV71) and Coxsackievirus A16 (CVA16) infection is usually self-limited but occasionally leads to severe pulmonary edema,
Huiqiang Wang, Huiqiang Wang, Tingting Guo, Yajun Yang, Lian Yu, Xiandao Pan, Yuhuan Li, Yuhuan Li   +7 more
doaj   +1 more source

The importance of including toxicity assays when screening plant extracts for antimalarial activity [PDF]

, 2011
Identifying plant extracts as sources of antimalarial compounds needs to be addressed as numerous studies screen extracts without the means of eliminating extracts that are merely cytotoxic.
Griffiths, S, Malan, SF, van Dyk, S, van Zyl, RL   +3 more
core   +2 more sources

多成分複合反応剤を用いる不斉反応の開拓 [PDF]

, 2006
平成15-17年度科学研究費補助金(基盤研究(B)(2))研究成果報告書　課題番号：15390005　研究代表者：富岡 清 (京都大学薬学研究科 ...
富岡, 清
core  

Wild Argentinian Amaryllidaceae, a New Renewable Source of the Acetylcholinesterase Inhibitor Galanthamine and Other Alkaloids

Molecules, 2012
The Amaryllidaceae family is well known for its pharmacologically active alkaloids. An important approach to treat Alzheimer’s disease involves the inhibition of the enzyme acetylcholinesterase (AChE).
Gabriela E. Feresin, Jaume Bastida, Alejandro Tapia, German Roitman, Cristina Theoduloz, Strahil Berkov, Natalia B. Pigni, Javier E. Ortiz   +7 more
doaj   +1 more source

Enhancement of alkaloid content (galanthamine and lycorine) and antioxidant activities (enzymatic and non-enzymatic) unders salt stress in summer snowflake (Leucojum aestivum L.)

, 2021
Muhammed Tural Ates, Arzu Birinci Yıldırım, Arzu Uçar Türker   +2 more
openalex   +1 more source

Expression of Concern: “Interplay Between Autophagy and Apoptosis in Lycorine Hydrochloride-Induced Cytotoxicity of HCT116 Cells” [PDF]

, 2023

openalex   +1 more source