Results 111 to 120 of about 30,187 (260)

Non-coding RNAs as Regulators of Lymphangiogenesis in Lymphatic Development, Inflammation, and Cancer Metastasis

Frontiers in Oncology, 2019
Non-coding RNAs (ncRNAs), which do not encode proteins, have pivotal roles in manipulating gene expression in development, physiology, and pathology. Emerging data have shown that ncRNAs can regulate lymphangiogenesis, which refers to lymphatics deriving
Ming-xin Cao, Ya-ling Tang, Wei-long Zhang, Ya-Jie Tang, Ya-Jie Tang, Xin-hua Liang   +5 more
doaj   +1 more source

Targeted Therapies for Slow‐Flow Vascular Malformations

Australasian Journal of Dermatology, Volume 66, Issue 3, Page 142-151, May 2025.
ABSTRACT Advances in genetic sequencing technologies have enabled the identification of key activating somatic variants in cellular signalling pathways involved in the pathogenesis of vascular malformations. Given that these genetic variants are also implicated in the pathogenesis of several cancers, the repurposing of targeted therapies developed in ...
Grace X. Li, Deshan F. Sebaratnam, James P. Pham   +2 more
wiley   +1 more source

Role of lymphangiogenesis in lung cancer.

Folia Histochemica et Cytobiologica, 2010
Lung cancer represents one of the most frequent causes of death due to neoplastic disease in Poland and around the world. The high mortality which accompany neoplastic diseases used to be ascribed mainly to dissemination of cancerous cells.
Renata Jankowska, Piotr Dziegiel, Bozena Weryńska   +2 more
doaj   +1 more source

Lymphangiogenèse et progression tumorale [PDF]

, 2007
National audienceNumerous data show a functional link between lymphangiogenesis, lymph node invasion by tumoral cells and metastasis. During the last decade, the identification of lymphatic endothelial cell-specific markers has allowed the investigation ...
Feige, Jean-Jacques, Vittet, Daniel
core   +1 more source

MT1-MMP sheds LYVE-1 on lymphatic endothelial cells and suppresses VEGF-C production to inhibit lymphangiogenesis [PDF]

, 2016
Lymphangiogensis is involved in various pathological conditions, such as arthritis and cancer metastasis. Although many factors have been identified to stimulate lymphatic vessel growth, little is known about lymphangiogenesis inhibitors.
Cao, R, Cao, Y, Jin, G, Wong, HLX, Zhang, S, Zhou, Z   +5 more
core   +1 more source

Preclinical Evaluation of Closed Incisional Negative Pressure Therapy on Post‐Surgical Oedema and Lymphatic Activity

International Wound Journal, Volume 22, Issue 5, May 2025.
ABSTRACT Closed incisional Negative Pressure Therapy (ciNPT) has demonstrated improved post‐surgical healing with reduced oedema and hematoma/seroma formation in patients. The underlying mechanism of action is poorly understood, although evidence indicates that lymphatics play a role.
John C. Rasmussen, Marisa Schmidt, Janelle E. Morton, Samantha Mann, Kristine Kieswetter, Eva M. Sevick‐Muraca   +5 more
wiley   +1 more source

Lymphangiogenesis requires Ang2/Tie/PI3K signaling for VEGFR3 cell-surface expression

The Journal of Clinical Investigation, 2022
Vascular endothelial growth factor C (VEGF-C) induces lymphangiogenesis via VEGF receptor 3 (VEGFR3), which is encoded by the most frequently mutated gene in human primary lymphedema. Angiopoietins (Angs) and their Tie receptors regulate lymphatic vessel
Emilia A. Korhonen, Aino Murtomäki, Sawan Kumar Jha, Andrey Anisimov, Anne Pink, Yan Zhang, Simon Stritt, Inam Liaqat, Lukas Stanczuk, Laura Alderfer, Zhiliang Sun, Emmi Kapiainen, Abhishek Singh, Ibrahim Sultan, Anni Lantta, Veli-Matti Leppänen, Lauri Eklund, Yulong He, Hellmut G. Augustin, Kari Vaahtomeri, Pipsa Saharinen, Taija Mäkinen, Kari Alitalo   +22 more
doaj   +1 more source

Characterising Shared and Specific Cell–Cell Communication in Cardiomyopathy Subtypes From Single‐Cell Transcriptomics Data

Journal of Cellular and Molecular Medicine, Volume 29, Issue 9, May 2025.
ABSTRACT Cardiomyopathy encompasses a diverse range of conditions characterised by extensive molecular heterogeneity, particularly the variations in cell–cell communication events such as ligand‐receptor interactions and downstream signalling. Understanding the common and unique features of these intercellular interactions is crucial for advancing ...
Wenqi Tao, Miao Gong, Zunping Ke
wiley   +1 more source

Lysyl Oxidase-Like Protein 2 Promotes Tumor Lymphangiogenesis and Lymph Node Metastasis in Breast Cancer

Neoplasia: An International Journal for Oncology Research, 2019
Tumor lymphangiogenesis has been previously documented to predict regional lymph node metastasis and promote the spread to distant organs. However, the underlying mechanism initiating tumor lymphangiogenesis remains unclear.
Chunying Wang, Siran Xu, Yang Tian, Anji Ju, Qiaoyun Hou, Jie Liu, Yan Fu, Yongzhang Luo   +7 more
doaj  

Lymphatics at the crossroads of angiogenesis and lymphangiogenesis

Journal of Anatomy, 2004
AbstractThe lymphatic system is implicated in interstitial fluid balance regulation, immune cell trafficking, oedema and cancer metastasis. However, the sequence of events that initiate and coordinate lymphatic vessel development (lymphangiogenesis) remains obscure.
SCAVELLI, C., WEBER, E., AGLIANO', M., CIRULLI, T., NICO, B., VACCA, A., RIBATTI, D.   +6 more
openaire   +5 more sources