Results 111 to 120 of about 30,187 (260)
Non-coding RNAs (ncRNAs), which do not encode proteins, have pivotal roles in manipulating gene expression in development, physiology, and pathology. Emerging data have shown that ncRNAs can regulate lymphangiogenesis, which refers to lymphatics deriving
Ming-xin Cao+5 more
doaj +1 more source
Targeted Therapies for Slow‐Flow Vascular Malformations
ABSTRACT Advances in genetic sequencing technologies have enabled the identification of key activating somatic variants in cellular signalling pathways involved in the pathogenesis of vascular malformations. Given that these genetic variants are also implicated in the pathogenesis of several cancers, the repurposing of targeted therapies developed in ...
Grace X. Li+2 more
wiley +1 more source
Role of lymphangiogenesis in lung cancer.
Lung cancer represents one of the most frequent causes of death due to neoplastic disease in Poland and around the world. The high mortality which accompany neoplastic diseases used to be ascribed mainly to dissemination of cancerous cells.
Renata Jankowska+2 more
doaj +1 more source
Lymphangiogenèse et progression tumorale [PDF]
National audienceNumerous data show a functional link between lymphangiogenesis, lymph node invasion by tumoral cells and metastasis. During the last decade, the identification of lymphatic endothelial cell-specific markers has allowed the investigation ...
Feige, Jean-Jacques, Vittet, Daniel
core +1 more source
MT1-MMP sheds LYVE-1 on lymphatic endothelial cells and suppresses VEGF-C production to inhibit lymphangiogenesis [PDF]
Lymphangiogensis is involved in various pathological conditions, such as arthritis and cancer metastasis. Although many factors have been identified to stimulate lymphatic vessel growth, little is known about lymphangiogenesis inhibitors.
Cao, R+5 more
core +1 more source
ABSTRACT Closed incisional Negative Pressure Therapy (ciNPT) has demonstrated improved post‐surgical healing with reduced oedema and hematoma/seroma formation in patients. The underlying mechanism of action is poorly understood, although evidence indicates that lymphatics play a role.
John C. Rasmussen+5 more
wiley +1 more source
Lymphangiogenesis requires Ang2/Tie/PI3K signaling for VEGFR3 cell-surface expression
Vascular endothelial growth factor C (VEGF-C) induces lymphangiogenesis via VEGF receptor 3 (VEGFR3), which is encoded by the most frequently mutated gene in human primary lymphedema. Angiopoietins (Angs) and their Tie receptors regulate lymphatic vessel
Emilia A. Korhonen+22 more
doaj +1 more source
ABSTRACT Cardiomyopathy encompasses a diverse range of conditions characterised by extensive molecular heterogeneity, particularly the variations in cell–cell communication events such as ligand‐receptor interactions and downstream signalling. Understanding the common and unique features of these intercellular interactions is crucial for advancing ...
Wenqi Tao, Miao Gong, Zunping Ke
wiley +1 more source
Tumor lymphangiogenesis has been previously documented to predict regional lymph node metastasis and promote the spread to distant organs. However, the underlying mechanism initiating tumor lymphangiogenesis remains unclear.
Chunying Wang+7 more
doaj
Lymphatics at the crossroads of angiogenesis and lymphangiogenesis
AbstractThe lymphatic system is implicated in interstitial fluid balance regulation, immune cell trafficking, oedema and cancer metastasis. However, the sequence of events that initiate and coordinate lymphatic vessel development (lymphangiogenesis) remains obscure.
SCAVELLI, C.+6 more
openaire +5 more sources