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Cell and Tissue Research, 1999
About 8-9 decades ago the development of embryonic lymphatics was studied intensively. Since then our knowledge has not considerably increased in this field, and it is still unknown whether lymphatics are derived by sprouting from veins, de novo from lymphangioblasts, or by both mechanisms.
Wilting, Jörg +2 more
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About 8-9 decades ago the development of embryonic lymphatics was studied intensively. Since then our knowledge has not considerably increased in this field, and it is still unknown whether lymphatics are derived by sprouting from veins, de novo from lymphangioblasts, or by both mechanisms.
Wilting, Jörg +2 more
openaire +3 more sources
Cytokines regulating lymphangiogenesis
Current Opinion in Immunology, 2018Lymphatic vessels are established by differentiation of lymphendothelial progenitors during embryogenesis. Lymphangiogenesis, the formation of new lymphatic vessels from pre-existing ones is rare in the healthy adult but takes place during pathological conditions such as inflammation, tissue repair and tumor growth.
Miguel, Sáinz-Jaspeado +1 more
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Lymphangiogenesis New Mechanisms
Annals of the New York Academy of Sciences, 2002Abstract: A mouse model has been developed to study lymphangiogenesis dissociated from angiogenesis. bFGF implanted in a mouse cornea at a concentration below the threshold to induce angiogenesis potently induces lymphangiogenesis. This model has permitted a study of cellular and molecular mechanisms of lymphangiogenesis.
Lynn, Chang +2 more
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Lymphangiogenesis and cancer metastasis
Nature Reviews Cancer, 2002Lymphatic vessels are important for the spread of solid tumours, but the mechanisms that underlie lymphatic spread and the role of lymphangiogenesis (the growth of lymphatics) in tumour metastasis has been less clear. This article reviews recent experimental and clinico-pathological data indicating that growth factors that stimulate lymphangiogenesis ...
Steven A Stacker +2 more
exaly +3 more sources
Inflammatory Triggers of Lymphangiogenesis
Lymphatic Research and Biology, 2003Inflammation is the common denominator to the postnatal events that overlap with lymphatic vessel growth, or lymphangiogenesis. Undoubtedly, inflammation and accompanying fluid overload are cardinal factors in wound healing, lymphedema, the pathogenesis of some forms of lymphangiomatosis, and solid tumor lymphangiogenesis.
Carla, Mouta, Mélanie, Heroult
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Molecular lymphangiogenesis: new players
Trends in Cell Biology, 2005The function of the lymphatic vascular system as a conduit for immune cells and excess tissue fluid has been known for over a century, but the molecular players involved in lymphangiogenesis--the formation of lymphatic vessels--have remained unknown until recently.
Tuomas, Tammela +2 more
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Corneal angiogenesis and lymphangiogenesis
Current Opinion in Allergy & Clinical Immunology, 2012The purpose of the present review is to describe new antilymphangiogenic treatment strategies and recent findings on strain-dependency of corneal lymphangiogenesis and the interdependency between blood and lymphatic vessel growth.Studies on mice have revealed that apart from haemangiogenesis, lymphangiogenesis can also differ markedly between several ...
Birgit, Regenfuss +2 more
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Signaling angiogenesis and lymphangiogenesis
Current Opinion in Cell Biology, 1998Exciting progress has been made in elucidating the complex network of receptor-ligand interactions that regulate blood vessel growth. Understanding these control mechanisms is of interest not only because of their role in developmental biology, but because they provide potential therapeutic strategies for disease processes involving angiogenesis, such ...
E I, Korpelainen, K, Alitalo
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Glucocorticoids Suppress Corneal Lymphangiogenesis
Cornea, 2011To determine whether glucocorticoids suppress corneal lymphatic vessel growth (lymphangiogenesis) or induce lymphatic vessel regression.We measured human lymphatic endothelial cell proliferation and collagen-induced tubulogenesis in culture conditions with and without dexamethasone, a potent glucocorticoid.
Maria M, Steele +3 more
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